Herbicidal thiadiazabicyclononane derivatives

ABSTRACT

Thiadiazabicyclononane derivatives of the formula I ##STR1## (R 1  =H, F; R 2  =halogen; R 3  =H, C 1  -C 4  -alkyl; R 4  =H, C 1  -C 8  -alkoxycarbonyl, C 3  -C 6  -alkenyloxycarbonyl or C 3  -C 5  -alkynyloxycarbonyl, and these 3 groups may additionally bear C 1  -C 4  -alkoxy; X, Y, Z=O,= S; a=C 2  -C 3  -alkylene chain which in addition to R 4  may bear up to 3 identical or different radicals R 5  : OH, COOH, C 1  -C 4  -alkyl or C 1  -C 6  -alkoxycarbonyl, and the last two radicals may in turn bear up to 5 halogen atoms or one of the following substituents; OH, CN, SH, C 1  -C 4  -alkoxy, C 1  -C 6  -alkylthio, C 3  -C 6  -alkenyloxy, C 3  -C 6  -alkenylthio, C 3  -C 6  -alkynyloxy, C 3  -C 6  -alkynylthio, C 1  -C 6  -alkylcarbonyloxy, C 1  -C 6  -alkoxycarbonyl, C 1  -C 6  -alkoxycarbonyl-C 1  -C 4  -alkoxy or C 1  -C 6  -alkoxycarbonyl-C 1  -C 4  -alkylthio). 
     These thiadiazabicyclononane derivatives are suitable for use as herbicides.

The present invention relates to novel thiadiazabicyclononane derivatives of the general formula I ##STR2## where the dotted bond is a possible additional bond and the substituents have the following meanings:

R¹ is hydrogen or fluorine;

R² is halogen;

R³ is hydrogen or C₁ -C₄ -alkyl;

R⁴ is hydrogen, C₁ -C₈ -alkoxycarbonyl, C₃ -C₆ -alkenyloxycarbonyl or C₃ -C₆ -alkynyloxycarbonyl, it being possible for each of these 3 groups to additionally carry a C₁ -C₄ -alkoxy radical;

X, Y and Z are oxygen or sulfur;

A is a C₂ -C₃ -alkylene chain which, in addition to R⁴, may carry up to three identical or different radicals R⁵ : hydroxyl, carboxyl, C₁ -C₄ -alkyl or C₁ -C₆ -alkoxycarbonyl, it being possible for the two lastmentioned radicals themselves to carry up to 5 halogen atoms and/or one of the following substituents: hydroxyl, cyano, mercapto, C₁ -C₄ -alkoxy, C₁ -C₆ -thio, C₃ -C₆ -alkenyloxy, C₃ -C₆ -alkenylthio, C₃ -C₆ -alkynyloxy, C₃ -C₆ -alkynylthio, C₁ -C₆ -alkoxycarbonyl-C₁ -C₄ -alkoxy or C₁ -C₆ -alkoxycarbonyl-C₁ -C₄ -alkylthio.

The present invention furthermore relates to processes for the preparation of these compounds, and to the use thereof as herbicides.

Herbicidal acetals and thioacetals of benzaldehyde whose phenyl ring is substituted in the metaposition to the acetal group by a tetrahydrophthalimide radical and which, in addition, carries comparable substituents R¹ and R² have been disclosed in EP-A-207,894, EP-A-0,319,791, DE-A-3,741,273 and DE-A-....... (P 3916292.3).

However, compounds which exhibit a good herbicidal action at low application rates are desirable.

It was therefore an object of the present invention to provide novel substances having an improved herbicidal action.

We have found that this object is achieved by the thiadiazabicyclononane derivatives I defined at the outset.

In addition, processes for the preparation of the compounds I, the use of these compounds as herbicides and herbicides containing these compounds have been found.

The compounds I are obtained, for example, by acetalating nitrobenzene of the general formula II in a conventional manner (Ferri, Reaktionen der org. Synthese; G. Thieme Verlag Stuttgart, pages 27ff.) using a compound IIIa in an inert organic solvent in the presence of an acid at from 0 to 180° C. preferably from 25 to 150° C., subsequently reducing the resultant acetal or thioacetal IV to give the aniline derivative V, and reacting V with thiophosgene to give the isothiocyanate VI, subjecting VI to an addition reaction with a cyclic hydrazine of the formula VII, and finally cyclizing the product. ##STR3##

The acetalation of II using IIIa is preferably carried out in an aprotic organic solvent, such as toluene or xylene, in particular toluene, in the presence of an acid, such as p-toluenesulfonic acid as catalyst.

The reduction of the resultant acetal IV to give the aniline derivative V is carried out by generally conventional methods (Houben-Weyl, Vol. 4/1c, pages 507ff. and Vol. 4/1d, pages 470ff.), for example in the presence of inorganic reducing agents such as iron and tin (II) salts in aprotic polar solvents or in the presence of hydrogen on metal catalysts, such as platinum, palladium or Raney nickel, in aprotic polar solvents.

The formation of the isothiocyanates VI is carried out in a conventional manner at from 0 to 100° C., preferably at from 20 to 50° C., in a two-phase system, for example methylene chloride/water, or in an inert solvent, such as toluene, with addition of an organic base, eg. tert.-amines such as triethylamine.

The isothiocyanates VI are reacted with the compounds of the formula VII in aprotic polar solvents, such as tetrahydrofuran, at from 0 to 100° C., preferably at from 20 to 50° C. The cyclization to form the compounds of the general formula I is carried out at from 0 to 100° C., preferably at from 20 to 70° C., in a solvent, such as methylene chloride, with addition of a base, such as pyridine, by adding a phosgenating agent such as phosgene, thiophosgene or trichloromethyl chloroformate.

The process is generally carried out at atmospheric pressure or under the autogenous pressure of the particular solvent.

If R⁴ is hydrogen and A is an ethylene or propylene chain, which may carry from 1 to 3 C₁ -C₃ -alkyl groups, preferably methyl or ethyl, these thiadiazabicyclononane derivatives I can be transacetalated in a conventional manner to give further compounds I according to the invention.

In general, the molar ratios between starting compounds in the individual stages are from 1:1 to 1:2.

From equimolar amounts up to an approximately 5-fold excess, preferably a 3-fold excess, based on the amount of compound IV, of reducing agent are recommended for the reduction of the nitro compound IV to give the aniline derivative V.

The concentration of the starting materials in the solvent is generally from 0.05 to 5 mol/l, preferably from 0.1 to 2.5 mol/l.

The starting materials required are generally known or can be prepared by known methods.

As far as the use of the compounds I according to the invention as herbicides is concerned, the following radicals are preferred as substituents:

R¹ is hydrogen or fluorine, preferably hydrogen;

R² is halogen, such as fluorine, chlorine, bromine or iodine, preferably fluorine or chlorine;

R³ is hydrogen or alkyl, such as methyl, ethyl, n-propyl, isopropyl, n-butyl, i-butyl, sec.-butyl or tert.-butyl, preferably hydrogen, methyl or ethyl;

R⁴ is hydrogen, alkoxycarbonyl, such as methoxycarbonyl, ethoxycarbonyl,propyloxycarbonyl, 1-methylethoxycarbonyl, butyloxycarbonyl, 1-methylpropyloxycarbonyl, 2-methylpropyloxycarbonyl, 1,1-dimethylethoxycarbonyl, pentoxycarbonyl, 1-methylbutoxycarbonyl, 2-methylbutoxycarbonyl, 3-methylbutoxycarbonyl, 1,2-dimethylpropyloxycarbonyl, 1,1-dimethylpropyloxycarbonyl, 2,2-dimethylpropyloxycarbonyl, 1-ethylpropyloxycarbonyl, n-hexyloxycarbonyl, 1-methylpentyloxycarbonyl, 2-methylpentyloxycarbonyl, 3methylpentyloxycarbonyl, 4-methylpentyloxycarbonyl, 1,2-dimethylbutoxycarbonyl, 1,3-dimethylbutoxycarbonyl, 2,3-dimethylbutoxycarbonyl, 1,1-dimethylbutoxycarbonyl, 2,2-dimethylbutoxycarbonyl, 3,3-dimethylbutoxycarbonyl, 1,1,2-trimethylpropyloxycarbonyl, 1,2,2-trimethylpropyloxycarbonyl, 1-ethylbutoxycarbonyl, 2-ethylbutoxycarbonyl or 1-ethyl-2-methylpropyloxycarbonyl; alkenyloxycarbonyl, such as 2-propenyloxycarbonyl, 2-butenyloxycarbonyl, 3-butenyloxycarbonyl, 1-methyl-2-propenyloxycarbonyl, 2-methyl-2-propenyloxycarbonyl, 2-pentenyloxycarbonyl, 3-pentenyloxycarbonyl, 4-pentenyloxycarbonyl,1-methyl-2-butenyloxycarbonyl, 2-methyl-2-butenyloxycarbonyl, 3-methyl-2-butenyloxycarbonyl, 1-methyl-3-butenyloxycarbonyl, 2-methyl-3-butenyloxycarbonyl, 3-methyl-3-butenyloxycarbonyl, 1,1-dimethyl-2-propenyloxycarbonyl, 1,2-dimethyl-2-propenyloxycarbonyl, 1-ethyl-2-propenyloxycarbonyl, 2-hexenyloxycarbonyl, 3-hexenyloxycarbonyl, 4-hexenyloxycarbonyl, 5-hexenyloxycarbonyl, 1-methyl-2-pentenyloxycarbonyl, 2-methyl-2-pentenyloxycarbonyl, 3-methyl-2-pentenyloxycarbonyl, 4-methyl-2-pentenyloxycarbonyl, 1-methyl-3-pentenyloxycarbonyl, 2-methyl-3-pentenyloxycarbonyl, 3-methyl-3-pentenyloxycarbonyl, 4-methyl-3-pentenyloxycarbonyl, 1-methyl-4-pentenyloxycarbonyl, 2-methyl-4-pentenyloxycarbonyl, 3-methyl-4-pentenyloxycarbonyl, 4-methyl-4-pentenyloxycarbonyl, 1,1-dimethyl-2-butenyloxycarbonyl, 1,1-dimethyl-3-butenyloxycarbonyl, 1,2-dimethyl-2-butenyloxycarbonyl, 1,2-dimethyl-3-butenyloxycarbonyl, 1,3-dimethyl-2-butenyloxycarbonyl, 1,3-dimethyl-3-butenyloxycarbonyl, 2,2-dimethyl-3butenyloxycarbonyl, 2,3-dimethyl-2-butenyloxycarbonyl, 2,3-dimethyl-3-butenyloxycarbonyl, 1-ethyl-2-butenyloxycarbonyl, 1-ethyl-3-butenyloxycarbonyl, 2-ethyl-2-butenyloxycarbonyl, 2-ethyl-3-butenyloxycarbonyl, 1,1,2-trimethyl-2-propenyloxycarbonyl, 1-ethyl-1-methyl-2-propenyloxycarbonyl or 1-ethyl-2-methyl-2-propenyloxycarbonyl; alkynyloxycarbonyl, such as 2-propenyloxycarbonyl, 2-butenyloxycarbonyl, 3-butenyloxycarbonyl, 1-methyl-2-propenyloxycarbonyl, 2-pentenyloxycarbonyl, 3-pentenyloxycarbonyl, 4-pentenyloxycarbonyl, 1-methyl-3-butenyloxycarbonyl, 2-methyl-3-butenyloxycarbonyl 1-methyl-2-butenyloxycarbonyl, 1,1-dimethyl-2-propenyloxycarbonyl, 1-ethyl-2-propenyloxycarbonyl, 2-hexenyloxycarbonyl, 3-hexenyloxycarbonyl, 4-hexenyloxycarbonyl, 5-hexenyloxycarbonyl, 1-methyl-2-pentenyloxycarbonyl, 1-methyl-3-pentenyloxycarbonyl, 1-methyl-4-pentenyloxycarbonyl, 2-methyl-3-pentenyloxycarbonyl, 2-methyl-4-pentenyloxycarbonyl, 3-methyl-4-pentenyloxycarbonyl, 4-methyl-2-pentenyloxycarbonyl, 1,1-dimethyl-2-butenyloxycarbonyl, 1,1-dimethyl-3-butenyloxycarbonyl, 1,2-dimethyl-3-butenyloxycarbonyl, 2,2-dimethyl-3-butenyloxycarbonyl, 1-ethyl-2-butenyloxycarbonyl, 1-ethyl-3-butenyloxycarbonyl, 2-ethyl-3-butenyloxycarbonyl or 1-ethyl-1-methyl-2-propenyloxycarbonyl;

it being possible for these groups to additionally carry an alkoxy radical, such as methoxy, ethoxy, propoxy, 1-methylethoxy, butoxy, 1-methylpropoxy, 2-methylpropoxy or 1,1-dimethylethoxy, preferably methoxy or ethoxy;

X and Y are oxygen or sulfur, preferably oxygen;

A is alkylene, such as 1,2-ethylene or 1,3-propylene, which may carry from one to three of the following radicals: hydroxyl; carboxyl; alkyl or alkoxycarbonyl, as mentioned in general and preferred terms in the case of R³ and R⁴ respectively, it being possible for the two last-mentioned radicals to themselves carry from one to five halogen atoms as mentioned in the case of R² or to carry one of the following radicals:cyano; mercapto; alkoxy as mentioned in the case of R⁴ ; alkenyloxy, such as 2-propenyloxy, 2-butenyloxy, 3-butenyloxy, 1-methyl-2-propenyloxy, 2-methyl-2-propenyloxy, 2-pentenyloxy, 3-pentenyloxy, 4-pentenyloxy, 1-methyl-2-butenyloxy, 2-methyl-2-butenyloxy, 3-methyl-2-butenyloxy, 1-methyl-3-butenyloxy, 2-methyl-3-butenyloxy, 3-methyl-3-butenyloxy, 1,1-dimethyl-2-propenyloxy, 1,2-dimethyl-2-propenyloxy, 1-ethyl-2-propenyloxy, 2-hexenyloxy, 3-hexenyloxy, 4-hexenyloxy, 5-hexenyloxy, 1-methyl-2-pentenyloxy, 2-methyl-2-pentenyloxy, 3-methyl-2-penenyloxy, 4-methyl-2 -pentenyloxy, 1-methyl-3-pentenyloxy, 2-methyl-3-pentenyloxy, 3-methyl-3-pentenyloxy, 4-methyl-3-pentenyloxy, 1-methyl-4-pentenyloxy, 2-methyl-4-pentenyloxy, 3-methyl-4-pentenyloxy, 4-methyl-4-pentenyloxy, 1,1-dimethyl-2-butenyloxy, 1,1-dimethyl-3-butenyloxy, 1,2-dimethyl-2-butenyloxy, 1,2-dimethyl-3-butenyloxy, 1,3-dimethyl-1-butenyloxy, 1,3-dimethyl-2-butenyloxy, 1,3-dimethyl-3-butenyloxy, 2,2-dimethyl-3-butenyloxy, 2,3-dimethyl-2-butenyloxy, 2,3-dimethyl-3-butenyloxy, 1-ethyl-2-butenyloxy, 1-ethyl-3-butenyloxy, 2-ethyl-2-butenyloxy, 2-ethyl-3-butenyloxy,1,1,2-trimethyl-2-propenyloxy, 1-ethyl-1-methyl-2-propenyloxy or 1-ethyl-2-methyl-2-propenyloxy; alkynyloxy, such as 2-propynyloxy, 2-butynyloxy, 3-butynyloxy, 1-methyl-2-propynyloxy, 2-pentynyloxy, 3-pentynyloxy, 4-pentynyloxy, 1-methyl-3-butynyloxy, 2-methyl-3-butynyloxy, 1-methyl-2-butynyloxy, 1,1-dimethyl-2-propynyloxy, 1-ethyl-2-propynyloxy, 2-hexynyloxy, 3-hexynyloxy, 4-hexynyloxy, 5-hexynyloxy, 1-methyl-2-pentynyloxy, 1-methyl-3-pentynyloxy, 1-methyl-4-pentynyloxy, 2-methyl-3-pentynyloxy, 2-methyl-4-pentynyloxy, 3-methyl-4-pentynyloxy, 4-methyl-2-pentynyloxy, 1,1-dimethyl-2-butynyloxy, 1,1-dimethyl-3-butynyloxy, 1,2-dimethyl-3-butynyloxy, 2,2-dimethyl-3-butynyloxy, 1 -ethyl-2-butynyloxy, 1-ethyl-3-butynyloxy, 2-ethyl-3-butynyloxy or 1-ethyl-1-methyl-2-propynyloxy; alkylcarbonyloxy, such as methylcarbonyloxy, ethylcarbonyloxy, propylcarbonyloxy, 1-methylethylcarbonyloxy, butylcarbonyloxy, 1-methylpropylcarbonyloxy, 2-methylpropylcarbonyloxy, 1,1-dimethylethylcarbonyloxy, pentylcarbonyloxy, 1-methylbutylcarbonyloxy, 2-methylbutylcarbonyloxy, 3-methylbutylcarbonyloxy, 1,2-dimethylpropylcarbonyloxy, 1,1-dimethylpropylcarbonyloxy, 2,2-dimethylpropylcarbonyloxy, 1-ethylpropylcarbonyloxy, n-hexylcarbonyloxy, 1-methylpentylcarbonyloxy, 2-methylpentylcarbonyloxy, 3-methylpentylcarbonyloxy, 4-methylpentylcarbonyloxy, 1,2-dimethylbutylcarbonyloxy, 1,3-dimethylbutylcarbonyloxy, 2,3-dimethylbutylcarbonyloxy, 1,1-dimethylbutylcarbonyloxy, 2,2-dimethylbutylcarbonyloxy, 3,3-dimethylbutylcarbonyloxy, 1,1,2-trimethylpropylcarbonyloxy, 1,2,2-trimethylpropylcarbonyloxy, 1-ethylbutylcarbonyloxy, 2-ethylbutylcarbonyloxy, or 1-ethyl-2-methylpropylcarbonyloxy; alkylthio, such as methylthio, ethylthio, 1-methylethylthio, butylthio, 1-methylpropylthio, 2-methylpropylthio or 1,1-dimethylethylthio; alkenylthio, such as 2-propenylthio, 2-butenylthio, 3-butenylthio, 1-methyl-2-propenylthio, 2-methyl-2-propenylthio, 2-pentenylthio, 3-pentenylthio, 4-pentenylthio, 1-methyl-2-butenylthio, 2-methyl-2-butenylthio, 3-methyl-2-butenylthio, 1-methyl-3-butenylthio, 2-methyl-3-butenylthio, 3-methyl-3-butenylthio, 1,1-dimethyl-2-propenylthio, 1,2-dimethyl-2-propenylthio, 1-ethyl-2-propenylthio, 2-hexenylthio, 3-hexenylthio, 4-hexenylthio, 5-hexenylthio, 1-methyl-2-pentenylthio, 2-methyl-2-pentenylthio, 3-methyl-2-pentenylthio, 4-methyl-2-pentenylthio, 1-methyl-3-pentenylthio, 2-methyl-3-pentenylthio, 3-methyl-3-pentenylthio, 4-methyl-3-pentenylthio, 1-methyl-4-pentenylthio, 2-methyl-4-pentenylthio, 3-methyl-4-pentenylthio, 4-methyl-4-pentenylthio, 1,1-dimethyl-2-butenylthio, 1,1-dimethyl-3-butenylthio, 1,2-dimethyl-2-butenylthio, 1,2-dimethyl-3-butenylthio, 1,3-dimethyl-1-butenylthio, 1,3-dimethyl-2-butenylthio, 1,3-dimethyl-3-butenylthio, 2,2-dimethyl-3-butenylthio, 2,3-dimethyl-2-butenylthio, 2,3-dimethyl-3-butenylthio, 1-ethyl-2-butenylthio, 1-ethyl-3-butenylthio, 2-ethyl-2-butenylthio,2-ethyl-3-butenylthio, 1,1,2-trimethyl-2-propenylthio, 1-ethyl-1-methyl-2-propenylthio or 1-ethyl-2-methyl-2-propenylthio; alkynylthio, such as 2-propynylthio, 2-butynylthio, 3-butynylthio, 1-methyl-2-propynylthio, 2-pentynylthio, 3-pentynylthio, 4-pentynylthio, 1-methyl-3-butynylthio, 2-methyl-3-butynylthio, 1-methyl-2-butynylthio, 1,1-dimethyl-2-propynylthio, 1-ethyl-2-propynylthio,2-hexynylthio, 3-hexynylthio, 4-hexynylthio, 5-hexynylthio, 1-methyl-2-pentynylthio, 1-methyl-3-pentynylthio, 1-methyl-4-pentynylthio, 2-methyl-3-pentynylthio, 2-methyl-4-pentynylthio, 3-methyl-4-pentynylthio, 4-methyl-2-pentynylthio, 1,1-dimethyl-2-butynylthio, 1,1-dimethyl-3-butynylthio, 1,2-dimethyl-3-butynylthio,2,2-dimethyl-3-butynylthio, 2-ethyl-3-butynylthio or 1-ethyl-1-methyl-2-propynylthio or alkoxycarbonyl as mentioned in the case of R⁴, which may be bonded directly or via one of the abovementioned alkoxy or alkylthio groups.

Particularly preferred compounds are those of the formulae Ia to If (m=0 or 1). ##STR4##

Table 1 lists examples of possible substituents of particularly preferred compounds Ia to Id, and Table 2 possible substituents of particularly preferred compounds Ie and If.

                                      TABLE 1                                      __________________________________________________________________________     X R.sup.1                                                                           R.sup.2                                                                           R.sup.3                                                                           m R.sup.5     R.sup.4                                               __________________________________________________________________________     S H  F  H  0 H           H                                                     O H  F  H  0 H           H                                                     S F  F  H  0 H           H                                                     O F  F  H  0 H           H                                                     S H  Cl H  0 H           H                                                     O H  Cl H  0 H           H                                                     S F  Cl H  0 H           H                                                     O F  Cl H  0 H           H                                                     S H  F  CH.sub.3                                                                          0 H           H                                                     O H  F  CH.sub.3                                                                          0 H           H                                                     S F  F  CH.sub.3                                                                          0 H           H                                                     O F  F  CH.sub.3                                                                          0 H           H                                                     S H  Cl CH.sub.3                                                                          0 H           H                                                     O H  Cl CH.sub.3                                                                          0 H           H                                                     S F  Cl CH.sub.3                                                                          0 H           H                                                     O F  Cl CH.sub.3                                                                          0 H           H                                                     S H  F  H  0 4-CH.sub.3  H                                                     O H  F  H  0 4-CH.sub.3  H                                                     S F  F  H  0 4-CH.sub.3  H                                                     O F  F  H  0 4-CH.sub.3  H                                                     S H  Cl H  0 4-CH.sub.3  H                                                     O H  Cl H  0 4-CH.sub.3  H                                                     S F  Cl H  0 4-CH.sub.3  H                                                     O F  Cl H  0 4-CH.sub.3  H                                                     S H  F  CH.sub.3                                                                          0 4-CH.sub.3  H                                                     O H  F  CH.sub.3                                                                          0 4-CH.sub.3  H                                                     S F  F  CH.sub.3                                                                          0 4-CH.sub.3  H                                                     O F  F  CH.sub.3                                                                          0 4-CH.sub.3  H                                                     S H  Cl CH.sub.3                                                                          0 4-CH.sub.3  H                                                     O H  Cl CH.sub.3                                                                          0 4-CH.sub.3  H                                                     S F  Cl CH.sub.3                                                                          0 4-CH.sub.3  H                                                     O F  Cl CH.sub.3                                                                          0 4-CH.sub.3  H                                                     S H  F  H  0 4,5-Di-CH.sub.3                                                                            H                                                     O H  F  H  0 4,5-Di-CH.sub.3                                                                            H                                                     S F  F  H  0 4,5-Di-CH.sub.3                                                                            H                                                     O F  F  H  0 4,5-Di-CH.sub.3                                                                            H                                                     S H  Cl H  0 4,5-Di-CH.sub.3                                                                            H                                                     O H  Cl H  0 4,5-Di-CH.sub.3                                                                            H                                                     S F  Cl H  0 4,5-Di-CH.sub.3                                                                            H                                                     O F  Cl H  0 4,5-Di-CH.sub.3                                                                            H                                                     S H  F  CH.sub.3                                                                          0 4,5-Di-CH.sub.3                                                                            H                                                     O H  F  CH.sub.3                                                                          0 4,5-Di-CH.sub.3                                                                            H                                                     S F  F  CH.sub.3                                                                          0 4,5-Di-CH.sub.3                                                                            H                                                     O F  F  CH.sub.3                                                                          0 4,5-Di-CH.sub.3                                                                            H                                                     S H  Cl CH.sub.3                                                                          0 4,5-Di-CH.sub.3                                                                            H                                                     O H  Cl CH.sub.3                                                                          0 4,5-Di-CH.sub.3                                                                            H                                                     S F  Cl CH.sub.3                                                                          0 4,5-Di-CH.sub.3                                                                            H                                                     O F  Cl CH.sub.3                                                                          0 4,5-Di-CH.sub.3                                                                            H                                                     S H  F  H  0 4-CH.sub.2 CH.sub.3                                                                        H                                                     O H  F  H  0 4-CH.sub.2 CH.sub.3                                                                        H                                                     S F  F  H  0 4-CH.sub.2 CH.sub.3                                                                        H                                                     O F  F  H  0 4-CH.sub.2 CH.sub.3                                                                        H                                                     S H  Cl H  0 4-CH.sub.2 CH.sub.3                                                                        H                                                     O H  Cl H  0 4-CH.sub.2 CH.sub.3                                                                        H                                                     S F  Cl H  0 4-CH.sub.2 CH.sub.3                                                                        H                                                     O F  Cl H  0 4-CH.sub.2 CH.sub.3                                                                        H                                                     S H  F  CH.sub.3                                                                          0 4-CH.sub.2 CH.sub.3                                                                        H                                                     O H  F  CH.sub.3                                                                          0 4-CH.sub.2 CH.sub.3                                                                        H                                                     S F  F  CH.sub.3                                                                          0 4-CH.sub.2 CH.sub.3                                                                        H                                                     O F  F  CH.sub.3                                                                          0 4-CH.sub.2 CH.sub.3                                                                        H                                                     S H  Cl CH.sub.3                                                                          0 4-CH.sub.2 CH.sub.3                                                                        H                                                     O H  Cl CH.sub.3                                                                          0 4-CH.sub.2 CH.sub.3                                                                        H                                                     S F  Cl CH.sub.3                                                                          0 4-CH.sub.2 CH.sub.3                                                                        H                                                     O F  Cl CH.sub.3                                                                          0 4-CH.sub.2 CH.sub.3                                                                        H                                                     S H  F  H  0 4-CH.sub.2 Cl                                                                              H                                                     O H  F  H  0 4-CH.sub.2 Cl                                                                              H                                                     S F  F  H  0 4-CH.sub.2 Cl                                                                              H                                                     O F  F  H  0 4-CH.sub.2 Cl                                                                              H                                                     S H  Cl H  0 4-CH.sub.2 Cl                                                                              H                                                     O H  Cl H  0 4-CH.sub.2 Cl                                                                              H                                                     S F  Cl H  0 4-CH.sub.2 Cl                                                                              H                                                     O F  Cl H  0 4-CH.sub.2 Cl                                                                              H                                                     S H  F  CH.sub.3                                                                          0 4-CH.sub.2 Cl                                                                              H                                                     O H  F  CH.sub.3                                                                          0 4-CH.sub.2 Cl                                                                              H                                                     S F  F  CH.sub.3                                                                          0 4-CH.sub.2 Cl                                                                              H                                                     O F  F  CH.sub.3                                                                          0 4-CH.sub.2 Cl                                                                              H                                                     S H  Cl CH.sub.3                                                                          0 4-CH.sub.2 Cl                                                                              H                                                     O H  Cl CH.sub.3                                                                          0 4-CH.sub.2 Cl                                                                              H                                                     S F  Cl CH.sub.3                                                                          0 4-CH.sub.2 Cl                                                                              H                                                     O F  Cl CH.sub.3                                                                          0 4-CH.sub.2 Cl                                                                              H                                                     S H  F  H  0 4-CH.sub.2 OH                                                                              H                                                     O H  F  H  0 4-CH.sub.2 OH                                                                              H                                                     S F  F  H  0 4-CH.sub.2 OH                                                                              H                                                     O F  F  H  0 4-CH.sub.2 OH                                                                              H                                                     S H  Cl H  0 4-CH.sub.2 OH                                                                              H                                                     O H  Cl H  0 4-CH.sub.2 OH                                                                              H                                                     S F  Cl H  0 4-CH.sub.2 OH                                                                              H                                                     O F  Cl H  0 4-CH.sub.2 OH                                                                              H                                                     S H  F  CH.sub.3                                                                          0 4-CH.sub.2 OH                                                                              H                                                     O H  F  CH.sub.3                                                                          0 4-CH.sub.2 OH                                                                              H                                                     S F  F  CH.sub.3                                                                          0 4-CH.sub.2 OH                                                                              H                                                     O F  F  CH.sub.3                                                                          0 4-CH.sub.2 OH                                                                              H                                                     S H  Cl CH.sub.3                                                                          0 4-CH.sub.2 OH                                                                              H                                                     O H  Cl CH.sub.3                                                                          0 4-CH.sub.2 OH                                                                              H                                                     S F  Cl CH.sub.3                                                                          0 4-CH.sub.2 OH                                                                              H                                                     O F  Cl CH.sub.3                                                                          0 4-CH.sub.2 OH                                                                              H                                                     S H  F  H  0 4-CH.sub.2 OCH.sub.3                                                                       H                                                     O H  F  H  0 4-CH.sub.2 OCH.sub.3                                                                       H                                                     S F  F  H  0 4-CH.sub.2 OCH.sub.3                                                                       H                                                     O F  F  H  0 4-CH.sub.2 OCH.sub.3                                                                       H                                                     S H  Cl H  0 4-CH.sub.2 OCH.sub.3                                                                       H                                                     O H  Cl H  0 4-CH.sub.2 OCH.sub.3                                                                       H                                                     S F  Cl H  0 4-CH.sub.2 OCH.sub.3                                                                       H                                                     O F  Cl H  0 4-CH.sub.2 OCH.sub.3                                                                       H                                                     S H  F  CH.sub.3                                                                          0 4-CH.sub.2 OCH.sub.3                                                                       H                                                     O H  F  CH.sub.3                                                                          0 4-CH.sub.2 OCH.sub.3                                                                       H                                                     S F  F  CH.sub. 3                                                                         0 4-CH.sub.2 OCH.sub.3                                                                       H                                                     O F  F  CH.sub.3                                                                          0 4-CH.sub.2 OCH.sub.3                                                                       H                                                     S H  Cl CH.sub.3                                                                          0 4-CH.sub.2 OCH.sub.3                                                                       H                                                     O H  Cl CH.sub.3                                                                          0 4-CH.sub.2 OCH.sub.3                                                                       H                                                     S F  Cl CH.sub.3                                                                          0 4-CH.sub.2 OCH.sub.3                                                                       H                                                     O F  Cl CH.sub.3                                                                          0 4-CH.sub.2 OCH.sub.3                                                                       H                                                     S H  F  H  0 4-CH.sub.2 OCH.sub.2 CH═CH.sub.2                                                       H                                                     O H  F  H  0 4-CH.sub.2 OCH.sub.2 CH═CH.sub.2                                                       H                                                     S F  F  H  0 4-CH.sub.2 OCH.sub.2 CH═CH.sub.2                                                       H                                                     O F  F  H  0 4-CH.sub.2 OCH.sub.2 CH═CH.sub.2                                                       H                                                     S H  Cl H  0 4-CH.sub.2 OCH.sub.2 CH═CH.sub.2                                                       H                                                     O H  Cl H  0 4-CH.sub.2 OCH.sub.2 CH═CH.sub.2                                                       H                                                     S F  Cl H  0 4-CH.sub.2 OCH.sub.2 CH═CH.sub.2                                                       H                                                     O F  Cl H  0 4-CH.sub.2 OCH.sub.2 CH═CH.sub.2                                                       H                                                     S H  F  CH.sub.3                                                                          0 4-CH.sub.2 OCH.sub.2 CH═CH.sub.2                                                       H                                                     O H  F  CH.sub.3                                                                          0 4-CH.sub.2 OCH.sub.2 CH═CH.sub.2                                                       H                                                     S F  F  CH.sub.3                                                                          0 4-CH.sub.2 OCH.sub.2 CH═CH.sub.2                                                       H                                                     O F  F  CH.sub.3                                                                          0 4-CH.sub.2 OCH.sub.2 CH═CH.sub.2                                                       H                                                     S H  Cl CH.sub.3                                                                          0 4-CH.sub.2 OCH.sub.2 CH═CH.sub.2                                                       H                                                     O H  Cl CH.sub.3                                                                          0 4-CH.sub.2 OCH.sub.2 CH═CH.sub.2                                                       H                                                     S F  Cl CH.sub.3                                                                          0 4-CH.sub.2 OCH.sub.2 CH═CH.sub.2                                                       H                                                     O F  Cl CH.sub.3                                                                          0 4-CH.sub.2 OCH.sub.2 CH═CH.sub.2                                                       H                                                     S H  F  H  0 4-CH.sub.2 OCH.sub.2 C.tbd.CH                                                              H                                                     O H  F  H  0 4-CH.sub.2 OCH.sub.2 C.tbd.CH                                                              H                                                     S F  F  H  0 4-CH.sub.2 OCH.sub.2 C.tbd.CH                                                              H                                                     O F  F  H  0 4-CH.sub.2 OCH.sub.2 C.tbd.CH                                                              H                                                     S H  Cl H  0 4-CH.sub.2 OCH.sub.2 C.tbd.CH                                                              H                                                     O H  Cl H  0 4-CH.sub.2 OCH.sub.2 C.tbd.CH                                                              H                                                     S F  Cl H  0 4-CH.sub.2 OCH.sub.2 C.tbd.CH                                                              H                                                     O F  Cl H  0 4-CH.sub.2 OCH.sub.2 C.tbd.CH                                                              H                                                     S H  F  CH.sub.3                                                                          0 4-CH.sub.2 OCH.sub.2 C.tbd.CH                                                              H                                                     O H  F  CH.sub.3                                                                          0 4-CH.sub.2 OCH.sub.2 C.tbd.CH                                                              H                                                     S F  F  CH.sub.3                                                                          0 4-CH.sub.2 OCH.sub.2 C.tbd.CH                                                              H                                                     O F  F  CH.sub.3                                                                          0 4-CH.sub.2 OCH.sub.2 C.tbd.CH                                                              H                                                     S H  Cl CH.sub.3                                                                          0 4-CH.sub.2 OCH.sub.2 C.tbd.CH                                                              H                                                     O H  Cl CH.sub.3                                                                          0 4-CH.sub.2 OCH.sub.2 C.tbd.CH                                                              H                                                     S F  Cl CH.sub.3                                                                          0 4-CH.sub.2 OCH.sub.2 C.tbd.CH                                                              H                                                     O F  Cl CH.sub.3                                                                          0 4-CH.sub.2 OCH.sub.2 C.tbd.CH                                                              H                                                     S H  F  H  0 4-CH.sub.2 OCOCH.sub.3                                                                     H                                                     O H  F  H  0 4-CH.sub.2 OCOCH.sub.3                                                                     H                                                     S F  F  H  0 4-CH.sub.2 OCOCH.sub.3                                                                     H                                                     O F  F  H  0 4-CH.sub.2 OCOCH.sub.3                                                                     H                                                     S H  Cl H  0 4-CH.sub.2 OCOCH.sub.3                                                                     H                                                     O H  Cl H  0 4-CH.sub.2 OCOCH.sub.3                                                                     H                                                     S F  Cl H  0 4-CH.sub.2 OCOCH.sub.3                                                                     H                                                     O F  Cl H  0 4-CH.sub.2 OCOCH.sub.3                                                                     H                                                     S H  F  CH.sub.3                                                                          0 4-CH.sub.2 OCOCH.sub.3                                                                     H                                                     O H  F  CH.sub.3                                                                          0 4-CH.sub.2 OCOCH.sub.3                                                                     H                                                     S F  F  CH.sub.3                                                                          0 4-CH.sub.2 OCOCH.sub.3                                                                     H                                                     O F  F  CH.sub.3                                                                          0 4-CH.sub.2 OCOCH.sub. 3                                                                    H                                                     S H  Cl CH.sub.3                                                                          0 4-CH.sub.2 OCOCH.sub.3                                                                     H                                                     O H  Cl CH.sub.3                                                                          0 4-CH.sub.2 OCOCH.sub.3                                                                     H                                                     S F  Cl CH.sub.3                                                                          0 4-CH.sub.2 OCOCH.sub.3                                                                     H                                                     O F  Cl CH.sub.3                                                                          0 4-CH.sub.2 OCOCH.sub.3                                                                     H                                                     S H  F  H  0 4-CH.sub.2 OCH.sub.2 CO.sub.2 CH.sub.3                                                     H                                                     O H  F  H  0 4-CH.sub.2 OCH.sub.2 CO.sub.2 CH.sub.3                                                     H                                                     S F  F  H  0 4-CH.sub.2 OCH.sub.2 CO.sub.2 CH.sub.3                                                     H                                                     O F  F  H  0 4-CH.sub.2 OCH.sub.2 CO.sub.2 CH.sub.3                                                     H                                                     S H  Cl H  0 4-CH.sub.2 OCH.sub.2 CO.sub.2 CH.sub.3                                                     H                                                     O H  Cl H  0 4-CH.sub.2 OCH.sub.2 CO.sub.2 CH.sub.3                                                     H                                                     S F  Cl H  0 4-CH.sub.2 OCH.sub.2 CO.sub.2 CH.sub.3                                                     H                                                     O F  Cl H  0 4-CH.sub.2 OCH.sub.2 CO.sub.2 CH.sub.3                                                     H                                                     S H  F  CH.sub.3                                                                          0 4-CH.sub.2 OCH.sub.2 CO.sub.2 CH.sub.3                                                     H                                                     O H  F  CH.sub.3                                                                          0 4-CH.sub.2 OCH.sub.2 CO.sub.2 CH.sub.3                                                     H                                                     S F  F  CH.sub.3                                                                          0 4-CH.sub.2 OCH.sub.2 CO.sub.2 CH.sub.3                                                     H                                                     O F  F  CH.sub.3                                                                          0 4-CH.sub.2 OCH.sub.2 CO.sub.2 CH.sub.3                                                     H                                                     S H  Cl CH.sub.3                                                                          0 4-CH.sub.2 OCH.sub.2 CO.sub.2 CH.sub.3                                                     H                                                     O H  Cl CH.sub.3                                                                          0 4-CH.sub.2 OCH.sub.2 CO.sub.2 CH.sub.3                                                     H                                                     S F  Cl CH.sub.3                                                                          0 4-CH.sub.2 OCH.sub.2 CO.sub.2 CH.sub.3                                                     H                                                     O F  Cl CH.sub.3                                                                          0 4-CH.sub.2 OCH.sub.2 CO.sub.2 CH.sub.3                                                     H                                                     S H  F  H  0 4-CH.sub.2 CO.sub.2 CH.sub.3                                                               H                                                     O H  F  H  0 4-CH.sub.2 CO.sub.2 CH.sub.3                                                               H                                                     S F  F  H  0 4-CH.sub.2 CO.sub.2 CH.sub.3                                                               H                                                     O F  F  H  0 4-CH.sub.2 CO.sub.2 CH.sub.3                                                               H                                                     S H  Cl H  0 4-CH.sub.2 CO.sub.2 CH.sub.3                                                               H                                                     O H  Cl H  0 4-CH.sub.2 CO.sub.2 CH.sub.3                                                               H                                                     S F  Cl H  0 4-CH.sub.2 CO.sub.2 CH.sub.3                                                               H                                                     O F  Cl H  0 4-CH.sub.2 CO.sub.2 CH.sub.3                                                               H                                                     S H  F  CH.sub.3                                                                          0 4-CH.sub.2 CO.sub.2 CH.sub.3                                                               H                                                     O H  F  CH.sub.3                                                                          0 4-CH.sub.2 CO.sub.2 CH.sub.3                                                               H                                                     S F  F  CH.sub.3                                                                          0 4-CH.sub.2 CO.sub.2 CH.sub.3                                                               H                                                     O F  F  CH.sub.3                                                                          0 4-CH.sub.2 CO.sub.2 CH.sub.3                                                               H                                                     S H  Cl CH.sub.3                                                                          0 4-CH.sub.2 CO.sub.2 CH.sub.3                                                               H                                                     O H  Cl CH.sub.3                                                                          0 4-CH.sub.2 CO.sub.2 CH.sub.3                                                               H                                                     S F  Cl CH.sub.3                                                                          0 4-CH.sub.2 CO.sub.2 CH.sub.3                                                               H                                                     O F  Cl CH.sub.3                                                                          0 4-CH.sub.2 CO.sub.2 CH.sub.3                                                               H                                                     S H  F  H  0 4-CH.sub.2 SH                                                                              H                                                     O H  F  H  0 4-CH.sub.2 SH                                                                              H                                                     S F  F  H  0 4-CH.sub.2 SH                                                                              H                                                     O F  F  H  0 4-CH.sub.2 SH                                                                              H                                                     S H  Cl H  0 4-CH.sub.2 SH                                                                              H                                                     O H  Cl H  0 4-CH.sub.2 SH                                                                              H                                                     S F  Cl H  0 4-CH.sub.2 SH                                                                              H                                                     O F  Cl H  0 4-CH.sub.2 SH                                                                              H                                                     S H  F  CH.sub.3                                                                          0 4-CH.sub.2 SH                                                                              H                                                     O H  F  CH.sub.3                                                                          0 4-CH.sub.2 SH                                                                              H                                                     S F  F  CH.sub.3                                                                          0 4-CH.sub.2 SH                                                                              H                                                     O F  F  CH.sub.3                                                                          0 4-CH.sub.2 SH                                                                              H                                                     S H  Cl CH.sub.3                                                                          0 4-CH.sub.2 SH                                                                              H                                                     O H  Cl CH.sub.3                                                                          0 4-CH.sub.2 SH                                                                              H                                                     S F  Cl CH.sub.3                                                                          0 4-CH.sub.2 SH                                                                              H                                                     O F  Cl CH.sub.3                                                                          0 4-CH.sub.2 SH                                                                              H                                                     S H  F  H  0 4-CH.sub.2 SCH.sub.2 CH.sub.3                                                              H                                                     O H  F  H  0 4-CH.sub.2 SCH.sub.2 CH.sub.3                                                              H                                                     S F  F  H  0 4-CH.sub.2 SCH.sub.2 CH.sub.3                                                              H                                                     O F  F  H  0 4-CH.sub.2 SCH.sub.2 CH.sub.3                                                              H                                                     S H  Cl H  0 4-CH.sub.2 SCH.sub.2 CH.sub.3                                                              H                                                     O H  Cl H  0 4-CH.sub.2 SCH.sub.2 CH.sub.3                                                              H                                                     S F  Cl H  0 4-CH.sub.2 SCH.sub.2 CH.sub.3                                                              H                                                     O F  Cl H  0 4-CH.sub.2 SCH.sub.2 CH.sub.3                                                              H                                                     S H  F  CH.sub.3                                                                          0 4-CH.sub.2 SCH.sub.2 CH.sub.3                                                              H                                                     O H  F  CH.sub.3                                                                          0 4-CH.sub.2 SCH.sub.2 CH.sub.3                                                              H                                                     S F  F  CH.sub.3                                                                          0 4-CH.sub.2 SCH.sub.2 CH.sub.3                                                              H                                                     O F  F  CH.sub.3                                                                          0 4-CH.sub.2 SCH.sub.2 CH.sub.3                                                              H                                                     S H  Cl CH.sub.3                                                                          0 4-CH.sub.2 SCH.sub.2 CH.sub.3                                                              H                                                     O H  Cl CH.sub.3                                                                          0 4-CH.sub.2 SCH.sub. 2 CH.sub.3                                                             H                                                     S F  Cl CH.sub.3                                                                          0 4-CH.sub.2 SCH.sub.2 CH.sub.3                                                              H                                                     O F  Cl CH.sub.3                                                                          0 4-CH.sub.2 SCH.sub.2 CH.sub.3                                                              H                                                     S H  F  H  0 4-CH.sub.2 SCH.sub.2 CH═CH.sub.2                                                       H                                                     O H  F  H  0 4-CH.sub.2 SCH.sub.2 CH═CH.sub.2                                                       H                                                     S F  F  H  0 4-CH.sub.2 SCH.sub.2 CH═CH.sub.2                                                       H                                                     O F  F  H  0 4-CH.sub.2 SCH.sub.2 CH═CH.sub.2                                                       H                                                     S H  Cl H  0 4-CH.sub.2 SCH.sub.2 CH═CH.sub.2                                                       H                                                     O H  Cl H  0 4-CH.sub.2 SCH.sub.2 CH═CH.sub.2                                                       H                                                     S F  Cl H  0 4-CH.sub.2 SCH.sub.2 CH═CH.sub.2                                                       H                                                     O F  Cl H  0 4-CH.sub.2 SCH.sub.2 CH═CH.sub.2                                                       H                                                     S H  F  CH.sub.3                                                                          0 4-CH.sub.2 SCH.sub.2 CH═CH.sub.2                                                       H                                                     O H  F  CH.sub.3                                                                          0 4-CH.sub.2 SCH.sub.2 CH═CH.sub.2                                                       H                                                     S F  F  CH.sub.3                                                                          0 4-CH.sub.2 SCH.sub.2 CH═CH.sub.2                                                       H                                                     O F  F  CH.sub.3                                                                          0 4-CH.sub.2 SCH.sub.2 CH═CH.sub.2                                                       H                                                     S H  Cl CH.sub.3                                                                          0 4-CH.sub.2 SCH.sub.2 CH═CH.sub.2                                                       H                                                     O H  Cl CH.sub.3                                                                          0 4-CH.sub.2 SCH.sub.2 CH═CH.sub.2                                                       H                                                     S F  Cl CH.sub.3                                                                          0 4-CH.sub.2 SCH.sub.2 CH═CH.sub.2                                                       H                                                     O F  Cl CH.sub.3                                                                          0 4-CH.sub.2 SCH.sub.2 CH═CH.sub.2                                                       H                                                     S H  F  H  0 4-CO.sub.2 H                                                                               H                                                     O H  F  H  0 4-CO.sub.2 H                                                                               H                                                     S F  F  H  0 4-CO.sub.2 H                                                                               H                                                     O F  F  H  0 4-CO.sub.2 H                                                                               H                                                     S H  Cl H  0 4-CO.sub.2 H                                                                               H                                                     O H  Cl H  0 4-CO.sub.2 H                                                                               H                                                     S F  Cl H  0 4-CO.sub.2 H                                                                               H                                                     O F  Cl H  0 4-CO.sub.2 H                                                                               H                                                     S H  F  CH.sub.3                                                                          0 4-CO.sub.2 H                                                                               H                                                     O H  F  CH.sub.3                                                                          0 4-CO.sub.2 H                                                                               H                                                     S F  F  CH.sub.3                                                                          0 4-CO.sub.2 H                                                                               H                                                     O F  F  CH.sub.3                                                                          0 4-CO.sub.2 H                                                                               H                                                     S H  Cl CH.sub.3                                                                          0 4-CO.sub.2 H                                                                               H                                                     O H  Cl CH.sub.3                                                                          0 4-CO.sub.2 H                                                                               H                                                     S F  Cl CH.sub.3                                                                          0 4-CO.sub.2 H                                                                               H                                                     O F  Cl CH.sub.3                                                                          0 4-CO.sub.2 H                                                                               H                                                     S H  F  H  1 H           H                                                     O H  F  H  1 H           H                                                     S F  F  H  1 H           H                                                     O F  F  H  1 H           H                                                     S H  Cl H  1 H           H                                                     O H  Cl H  1 H           H                                                     S F  Cl H  1 H           H                                                     O F  Cl H  1 H           H                                                     S H  F  CH.sub.3                                                                          1 H           H                                                     O H  F  CH.sub.3                                                                          1 H           H                                                     S F  F  CH.sub.3                                                                          1 H           H                                                     O F  F  CH.sub.3                                                                          1 H           H                                                     S H  Cl CH.sub.3                                                                          1 H           H                                                     O H  Cl CH.sub.3                                                                          1 H           H                                                     S F  Cl CH.sub.3                                                                          1 H           H                                                     O F  Cl CH.sub.3                                                                          1 H           H                                                     S H  F  H  1 4-CH.sub.3  H                                                     O H  F  H  1 4-CH.sub.3  H                                                     S F  F  H  1 4-CH.sub.3  H                                                     O F  F  H  1 4-CH.sub.3  H                                                     S H  Cl H  1 4-CH.sub.3  H                                                     O H  Cl H  1 4-CH.sub.3  H                                                     S F  Cl H  1 4-CH.sub.3  H                                                     O F  Cl H  1 4-CH.sub.3  H                                                     S H  F  CH.sub.3                                                                          1 4-CH.sub.3  H                                                     O H  F  CH.sub.3                                                                          1 4-CH.sub.3  H                                                     S F  F  CH.sub.3                                                                          1 4-CH.sub.3  H                                                     O F  F  CH.sub.3                                                                          1 4-CH.sub.3  H                                                     S H  Cl CH.sub.3                                                                          1 4-CH.sub.3  H                                                     O H  Cl CH.sub.3                                                                          1 4-CH.sub.3  H                                                     S F  Cl CH.sub.3                                                                          1 4-CH.sub.3  H                                                     O F  Cl CH.sub.3                                                                          1 4-CH.sub.3  H                                                     S H  F  H  1 4,6-Di-CH.sub.3                                                                            H                                                     O H  F  H  1 4,6-Di-CH.sub.3                                                                            H                                                     S F  F  H  1 4,6-Di-CH.sub.3                                                                            H                                                     O F  F  H  1 4,6-Di-CH.sub.3                                                                            H                                                     S H  Cl H  1 4,6-Di-CH.sub.3                                                                            H                                                     O H  Cl H  1 4,6-Di-CH.sub.3                                                                            H                                                     S F  Cl H  1 4,6-Di-CH.sub.3                                                                            H                                                     O F  Cl H  1 4,6-Di-CH.sub.3                                                                            H                                                     S H  F  CH.sub.3                                                                          1 4,6-Di-CH.sub.3                                                                            H                                                     O H  F  CH.sub.3                                                                          1 4,6-Di-CH.sub.3                                                                            H                                                     S F  F  CH.sub.3                                                                          1 4,6-Di-CH.sub.3                                                                            H                                                     O F  F  CH.sub.3                                                                          1 4,6-Di-CH.sub.3                                                                            H                                                     S H  Cl CH.sub.3                                                                          1 4,6-Di-CH.sub.3                                                                            H                                                     O H  Cl CH.sub.3                                                                          1 4,6-Di-CH.sub.3                                                                            H                                                     S F  Cl CH.sub.3                                                                          1 4,6-Di-CH.sub.3                                                                            H                                                     O F  Cl CH.sub.3                                                                          1 4,6-Di-CH.sub.3                                                                            H                                                     S H  F  H  1 4-CH.sub.2 CH.sub.3                                                                        H                                                     O H  F  H  1 4-CH.sub.2 CH.sub.3                                                                        H                                                     S F  F  H  1 4-CH.sub.2 CH.sub.3                                                                        H                                                     O F  F  H  1 4-CH.sub.2 CH.sub.3                                                                        H                                                     S H  Cl H  1 4-CH.sub.2 CH.sub.3                                                                        H                                                     O H  Cl H  1 4-CH.sub.2 CH.sub.3                                                                        H                                                     S F  Cl H  1 4-CH.sub.2 CH.sub.3                                                                        H                                                     O F  Cl H  1 4-CH.sub.2 CH.sub.3                                                                        H                                                     S H  F  CH.sub.3                                                                          1 4-CH.sub.2 CH.sub.3                                                                        H                                                     O H  F  CH.sub.3                                                                          1 4-CH.sub.2 CH.sub.3                                                                        H                                                     S F  F  CH.sub.3                                                                          1 4-CH.sub.2 CH.sub.3                                                                        H                                                     O F  F  CH.sub.3                                                                          1 4-CH.sub.2 CH.sub.3                                                                        H                                                     S H  Cl CH.sub.3                                                                          1 4-CH.sub.2 CH.sub.3                                                                        H                                                     O H  Cl CH.sub.3                                                                          1 4-CH.sub.2 CH.sub.3                                                                        H                                                     S F  Cl CH.sub.3                                                                          1 4-CH.sub.2 CH.sub.3                                                                        H                                                     O F  Cl CH.sub.3                                                                          1 4-CH.sub.2 CH.sub.3                                                                        H                                                     S H  F  H  1 4-CH.sub.2 Cl                                                                              H                                                     O H  F  H  1 4-CH.sub.2 Cl                                                                              H                                                     S F  F  H  1 4-CH.sub.2 Cl                                                                              H                                                     O F  F  H  1 4-CH.sub.2 Cl                                                                              H                                                     S H  Cl H  1 4-CH.sub.2 Cl                                                                              H                                                     O H  Cl H  1 4-CH.sub.2 Cl                                                                              H                                                     S F  Cl H  1 4-CH.sub.2 Cl                                                                              H                                                     O F  Cl H  1 4-CH.sub.2 Cl                                                                              H                                                     S H  F  CH.sub.3                                                                          1 4-CH.sub.2 Cl                                                                              H                                                     O H  F  CH.sub.3                                                                          1 4-CH.sub.2 Cl                                                                              H                                                     S F  F  CH.sub.3                                                                          1 4-CH.sub.2 Cl                                                                              H                                                     O F  F  CH.sub.3                                                                          1 4-CH.sub.2 Cl                                                                              H                                                     S H  Cl CH.sub.3                                                                          1 4-CH.sub.2 Cl                                                                              H                                                     O H  Cl CH.sub.3                                                                          1 4-CH.sub.2 Cl                                                                              H                                                     S F  Cl CH.sub.3                                                                          1 4-CH.sub.2 Cl                                                                              H                                                     O F  Cl CH.sub.3                                                                          1 4-CH.sub.2 Cl                                                                              H                                                     S H  F  H  1 4-CH.sub.2 OH                                                                              H                                                     O H  F  H  1 4-CH.sub.2 OH                                                                              H                                                     S F  F  H  1 4-CH.sub.2 OH                                                                              H                                                     O F  F  H  1 4-CH.sub.2 OH                                                                              H                                                     S H  Cl H  1 4-CH.sub.2 OH                                                                              H                                                     O H  Cl H  1 4-CH.sub.2 OH                                                                              H                                                     S F  Cl H  1 4-CH.sub.2 OH                                                                              H                                                     O F  Cl H  1 4-CH.sub.2 OH                                                                              H                                                     S H  F  CH.sub.3                                                                          1 4-CH.sub.2 OH                                                                              H                                                     O H  F  CH.sub.3                                                                          1 4-CH.sub.2 OH                                                                              H                                                     S F  F  CH.sub.3                                                                          1 4-CH.sub.2 OH                                                                              H                                                     O F  F  CH.sub.3                                                                          1 4-CH.sub.2 OH                                                                              H                                                     S H  Cl CH.sub.3                                                                          1 4-CH.sub.2 OH                                                                              H                                                     O H  Cl CH.sub.3                                                                          1 4-CH.sub.2 OH                                                                              H                                                     S F  Cl CH.sub.3                                                                          1 4-CH.sub.2 OH                                                                              H                                                     O F  Cl CH.sub.3                                                                          1 4-CH.sub.2 OH                                                                              H                                                     S H  F  H  1 4-CH.sub.2 OCH.sub.3                                                                       H                                                     O H  F  H  1 4-CH.sub.2 OCH.sub.3                                                                       H                                                     S F  F  H  1 4-CH.sub.2 OCH.sub.3                                                                       H                                                     O F  F  H  1 4-CH.sub.2 OCH.sub.3                                                                       H                                                     S H  Cl H  1 4-CH.sub.2 OCH.sub.3                                                                       H                                                     O H  Cl H  1 4-CH.sub.2 OCH.sub.3                                                                       H                                                     S F  Cl H  1 4-CH.sub.2 OCH.sub.3                                                                       H                                                     O F  Cl H  1 4-CH.sub.2 OCH.sub.3                                                                       H                                                     S H  F  CH.sub.3                                                                          1 4-CH.sub.2 OCH.sub.3                                                                       H                                                     O H  F  CH.sub.3                                                                          1 4-CH.sub.2 OCH.sub.3                                                                       H                                                     S F  F  CH.sub.3                                                                          1 4-CH.sub.2 OCH.sub.3                                                                       H                                                     O F  F  CH.sub.3                                                                          1 4-CH.sub.2 OCH.sub.3                                                                       H                                                     S H  Cl CH.sub.3                                                                          1 4-CH.sub.2 OCH.sub.3                                                                       H                                                     O H  Cl CH.sub.3                                                                          1 4-CH.sub.2 OCH.sub.3                                                                       H                                                     S F  Cl CH.sub. 3                                                                         1 4-CH.sub.2 OCH.sub.3                                                                       H                                                     O F  Cl CH.sub.3                                                                          1 4-CH.sub.2 OCH.sub.3                                                                       H                                                     S H  F  H  1 4-CH.sub.2 OCH.sub.2 CH═CH.sub.2                                                       H                                                     O H  F  H  1 4-CH.sub.2 OCH.sub.2 CH═CH.sub.2                                                       H                                                     S F  F  H  1 4-CH.sub.2 OCH.sub.2 CH═CH.sub.2                                                       H                                                     O F  F  H  1 4-CH.sub.2 OCH.sub.2 CH═CH.sub.2                                                       H                                                     S H  Cl H  1 4-CH.sub.2 OCH.sub.2 CH═CH.sub.2                                                       H                                                     O H  Cl H  1 4-CH.sub.2 OCH.sub.2 CH═CH.sub.2                                                       H                                                     S F  Cl H  1 4-CH.sub.2 OCH.sub.2 CH═CH.sub.2                                                       H                                                     O F  Cl H  1 4-CH.sub.2 OCH.sub.2 CH═CH.sub.2                                                       H                                                     S H  F  CH.sub.3                                                                          1 4-CH.sub.2 OCH.sub.2 CH═CH.sub.2                                                       H                                                     O H  F  CH.sub.3                                                                          1 4-CH.sub.2 OCH.sub.2 CH═CH.sub.2                                                       H                                                     S F  F  CH.sub.3                                                                          1 4-CH.sub.2 OCH.sub.2 CH═CH.sub.2                                                       H                                                     O F  F  CH.sub.3                                                                          1 4-CH.sub.2 OCH.sub.2 CH═CH.sub.2                                                       H                                                     S H  Cl CH.sub.3                                                                          1 4-CH.sub.2 OCH.sub.2 CH═CH.sub.2                                                       H                                                     O H  Cl CH.sub.3                                                                          1 4-CH.sub.2 OCH.sub.2 CH═CH.sub. 2                                                      H                                                     S F  Cl CH.sub.3                                                                          1 4-CH.sub.2 OCH.sub.2 CH═CH.sub.2                                                       H                                                     O F  Cl CH.sub.3                                                                          1 4-CH.sub.2 OCH.sub.2 CH═CH.sub.2                                                       H                                                     S H  F  H  1 4-CH.sub.2 OCH.sub.2 C.tbd.CH                                                              H                                                     O H  F  H  1 4-CH.sub.2 OCH.sub.2 C.tbd.CH                                                              H                                                     S F  F  H  1 4-CH.sub.2 OCH.sub.2 C.tbd.CH                                                              H                                                     O F  F  H  1 4-CH.sub.2 OCH.sub.2 C.tbd.CH                                                              H                                                     S H  Cl H  1 4-CH.sub.2 OCH.sub.2 C.tbd.CH                                                              H                                                     O H  Cl H  1 4-CH.sub.2 OCH.sub.2 C.tbd.CH                                                              H                                                     S F  Cl H  1 4-CH.sub.2 OCH.sub.2 C.tbd.CH                                                              H                                                     O F  Cl H  1 4-CH.sub.2 OCH.sub.2 C.tbd.CH                                                              H                                                     S H  F  CH.sub.3                                                                          1 4-CH.sub.2 OCH.sub.2 C.tbd.CH                                                              H                                                     O H  F  CH.sub.3                                                                          1 4-CH.sub.2 OCH.sub.2 C.tbd.CH                                                              H                                                     S F  F  CH.sub.3                                                                          1 4-CH.sub.2 OCH.sub.2 C.tbd.CH                                                              H                                                     O F  F  CH.sub.3                                                                          1 4-CH.sub.2 OCH.sub.2 C.tbd.CH                                                              H                                                     S H  Cl CH.sub.3                                                                          1 4-CH.sub.2 OCH.sub.2 C.tbd.CH                                                              H                                                     O H  Cl CH.sub.3                                                                          1 4-CH.sub.2 OCH.sub. 2 C.tbd.CH                                                             H                                                     S F  Cl CH.sub.3                                                                          1 4-CH.sub.2 OCH.sub.2 C.tbd.CH                                                              H                                                     O F  Cl CH.sub.3                                                                          1 4-CH.sub.2 OCH.sub.2 C.tbd.CH                                                              H                                                     S H  F  H  1 4-CH.sub.2 OCOCH.sub.3                                                                     H                                                     O H  F  H  1 4-CH.sub.2 OCOCH.sub.3                                                                     H                                                     S F  F  H  1 4-CH.sub.2 OCOCH.sub.3                                                                     H                                                     O F  F  H  1 4-CH.sub.2 OCOCH.sub.3                                                                     H                                                     S H  Cl H  1 4-CH.sub.2 OCOCH.sub.3                                                                     H                                                     O H  Cl H  1 4-CH.sub.2 OCOCH.sub.3                                                                     H                                                     S F  Cl H  1 4-CH.sub.2 OCOCH.sub.3                                                                     H                                                     O F  Cl H  1 4-CH.sub.2 OCOCH.sub.3                                                                     H                                                     S H  F  CH.sub.3                                                                          1 4-CH.sub.2 OCOCH.sub.3                                                                     H                                                     O H  F  CH.sub.3                                                                          1 4-CH.sub.2 OCOCH.sub.3                                                                     H                                                     S F  F  CH.sub.3                                                                          1 4-CH.sub.2 OCOCH.sub.3                                                                     H                                                     O F  F  CH.sub.3                                                                          1 4-CH.sub.2 OCOCH.sub.3                                                                     H                                                     S H  Cl CH.sub.3                                                                          1 4-CH.sub.2 OCOCH.sub.3                                                                     H                                                     O H  Cl CH.sub.3                                                                          1 4-CH.sub.2 OCOCH.sub.3                                                                     H                                                     S F  Cl CH.sub.3                                                                          1 4-CH.sub.2 OCOCH.sub.3                                                                     H                                                     O F  Cl CH.sub.3                                                                          1 4-CH.sub.2 OCOCH.sub.3                                                                     H                                                     S H  F  H  1 4-CH.sub.2 OCH.sub.2 CO.sub.2 CH.sub.3                                                     H                                                     O H  F  H  1 4-CH.sub.2 OCH.sub.2 CO.sub.2 CH.sub.3                                                     H                                                     S F  F  H  1 4-CH.sub.2 OCH.sub.2 CO.sub.2 CH.sub.3                                                     H                                                     O F  F  H  1 4-CH.sub.2 OCH.sub.2 CO.sub.2 CH.sub.3                                                     H                                                     S H  Cl H  1 4-CH.sub.2 OCH.sub.2 CO.sub.2 CH.sub.3                                                     H                                                     O H  Cl H  1 4-CH.sub.2 OCH.sub.2 CO.sub.2 CH.sub.3                                                     H                                                     S F  Cl H  1 4-CH.sub.2 OCH.sub.2 CO.sub.2 CH.sub.3                                                     H                                                     O F  Cl H  1 4-CH.sub.2 OCH.sub.2 CO.sub.2 CH.sub.3                                                     H                                                     S H  F  CH.sub.3                                                                          1 4-CH.sub.2 OCH.sub.2 CO.sub.2 CH.sub.3                                                     H                                                     O H  F  CH.sub.3                                                                          1 4-CH.sub.2 OCH.sub.2 CO.sub.2 CH.sub.3                                                     H                                                     S F  F  CH.sub.3                                                                          1 4-CH.sub.2 OCH.sub.2 CO.sub.2 CH.sub.3                                                     H                                                     O F  F  CH.sub.3                                                                          1 4-CH.sub.2 OCH.sub.2 CO.sub.2 CH.sub.3                                                     H                                                     S H  Cl CH.sub.3                                                                          1 4-CH.sub.2 OCH.sub.2 CO.sub.2 CH.sub.3                                                     H                                                     O H  Cl CH.sub.3                                                                          1 4-CH.sub.2 OCH.sub.2 CO.sub.2 CH.sub.3                                                     H                                                     S F  Cl CH.sub.3                                                                          1 4-CH.sub.2 OCH.sub.2 CO.sub.2 CH.sub.3                                                     H                                                     O F  Cl CH.sub.3                                                                          1 4-CH.sub.2 OCH.sub.2 CO.sub.2 CH.sub.3                                                     H                                                     S H  F  H  1 4-CH.sub.2 CO.sub.2 CH.sub.3                                                               H                                                     O H  F  H  1 4-CH.sub.2 CO.sub.2 CH.sub.3                                                               H                                                     S F  F  H  1 4-CH.sub.2 CO.sub.2 CH.sub.3                                                               H                                                     O F  F  H  1 4-CH.sub.2 CO.sub.2 CH.sub.3                                                               H                                                     S H  Cl H  1 4-CH.sub.2 CO.sub.2 CH.sub.3                                                               H                                                     O H  Cl H  1 4-CH.sub.2 CO.sub.2 CH.sub.3                                                               H                                                     S F  Cl H  1 4-CH.sub.2 CO.sub.2 CH.sub.3                                                               H                                                     O F  Cl H  1 4-CH.sub.2 CO.sub.2 CH.sub.3                                                               H                                                     S H  F  CH.sub.3                                                                          1 4-CH.sub.2 CO.sub.2 CH.sub.3                                                               H                                                     O H  F  CH.sub.3                                                                          1 4-CH.sub.2 CO.sub.2 CH.sub.3                                                               H                                                     S F  F  CH.sub.3                                                                          1 4-CH.sub.2 CO.sub.2 CH.sub.3                                                               H                                                     O F  F  CH.sub.3                                                                          1 4-CH.sub.2 CO.sub.2 CH.sub.3                                                               H                                                     S H  Cl CH.sub.3                                                                          1 4-CH.sub.2 CO.sub.2 CH.sub.3                                                               H                                                     O H  Cl CH.sub.3                                                                          1 4-CH.sub.2 CO.sub.2 CH.sub.3                                                               H                                                     S F  Cl CH.sub.3                                                                          1 4-CH.sub.2 CO.sub.2 CH.sub.3                                                               H                                                     O F  Cl CH.sub.3                                                                          1 4-CH.sub.2 CO.sub.2 CH.sub.3                                                               H                                                     S H  F  H  1 4-CH.sub.2 SH                                                                              H                                                     O H  F  H  1 4-CH.sub.2 SH                                                                              H                                                     S F  F  H  1 4-CH.sub.2 SH                                                                              H                                                     O F  F  H  1 4-CH.sub.2 SH                                                                              H                                                     S H  Cl H  1 4-CH.sub.2 SH                                                                              H                                                     O H  Cl H  1 4-CH.sub.2 SH                                                                              H                                                     S F  Cl H  1 4-CH.sub.2 SH                                                                              H                                                     O F  Cl H  1 4-CH.sub.2 SH                                                                              H                                                     S H  F  CH.sub.3                                                                          1 4-CH.sub.2 SH                                                                              H                                                     O H  F  CH.sub.3                                                                          1 4-CH.sub.2 SH                                                                              H                                                     S F  F  CH.sub.3                                                                          1 4-CH.sub.2 SH                                                                              H                                                     O F  F  CH.sub.3                                                                          1 4-CH.sub.2 SH                                                                              H                                                     S H  Cl CH.sub.3                                                                          1 4-CH.sub.2 SH                                                                              H                                                     O H  Cl CH.sub.3                                                                          1 4-CH.sub.2 SH                                                                              H                                                     S F  Cl CH.sub.3                                                                          1 4-CH.sub.2 SH                                                                              H                                                     O F  Cl CH.sub.3                                                                          1 4-CH.sub.2 SH                                                                              H                                                     S H  F  H  1 4-CH.sub.2 SCH.sub.2 CH.sub.3                                                              H                                                     O H  F  H  1 4-CH.sub.2 SCH.sub.2 CH.sub.3                                                              H                                                     S F  F  H  1 4-CH.sub.2 SCH.sub.2 CH.sub.3                                                              H                                                     O F  F  H  1 4-CH.sub.2 SCH.sub.2 CH.sub.3                                                              H                                                     S H  Cl H  1 4-CH.sub.2 SCH.sub.2 CH.sub.3                                                              H                                                     O H  Cl H  1 4-CH.sub.2 SCH.sub.2 CH.sub.3                                                              H                                                     S F  Cl H  1 4-CH.sub.2 SCH.sub.2 CH.sub.3                                                              H                                                     O F  Cl H  1 4-CH.sub.2 SCH.sub.2 CH.sub.3                                                              H                                                     S H  F  CH.sub.3                                                                          1 4-CH.sub.2 SCH.sub.2 CH.sub.3                                                              H                                                     O H  F  CH.sub.3                                                                          1 4-CH.sub.2 SCH.sub.2 CH.sub.3                                                              H                                                     S F  F  CH.sub.3                                                                          1 4-CH.sub.2 SCH.sub.2 CH.sub.3                                                              H                                                     O F  F  CH.sub.3                                                                          1 4-CH.sub.2 SCH.sub.2 CH.sub.3                                                              H                                                     S H  Cl CH.sub.3                                                                          1 4-CH.sub.2 SCH.sub.2 CH.sub.3                                                              H                                                     O H  Cl CH.sub.3                                                                          1 4-CH.sub.2 SCH.sub.2 CH.sub.3                                                              H                                                     S F  Cl CH.sub.3                                                                          1 4-CH.sub.2 SCH.sub.2 CH.sub.3                                                              H                                                     O F  Cl CH.sub.3                                                                          1 4-CH.sub.2 SCH.sub.2 CH.sub.3                                                              H                                                     S H  F  H  1 4-CH.sub.2 SCH.sub.2 CH═CH.sub.2                                                       H                                                     O H  F  H  1 4-CH.sub.2 SCH.sub.2 CH═CH.sub.2                                                       H                                                     S F  F  H  1 4-CH.sub.2 SCH.sub.2 CH═CH.sub.2                                                       H                                                     O F  F  H  1 4-CH.sub.2 SCH.sub.2 CH═CH.sub.2                                                       H                                                     S H  Cl H  1 4-CH.sub.2 SCH.sub.2 CH═CH.sub.2                                                       H                                                     O H  Cl H  1 4-CH.sub.2 SCH.sub.2 CH═CH.sub.2                                                       H                                                     S F  Cl H  1 4-CH.sub.2 SCH.sub.2 CH═CH.sub.2                                                       H                                                     O F  Cl H  1 4-CH.sub.2 SCH.sub.2 CH═CH.sub.2                                                       H                                                     S H  F  CH.sub.3                                                                          1 4-CH.sub.2 SCH.sub.2 CH═CH.sub.2                                                       H                                                     O H  F  CH.sub.3                                                                          1 4-CH.sub.2 SCH.sub.2 CH═CH.sub.2                                                       H                                                     S F  F  CH.sub.3                                                                          1 4-CH.sub.2 SCH.sub.2 CH═CH.sub.2                                                       H                                                     O F  F  CH.sub.3                                                                          1 4-CH.sub.2 SCH.sub.2 CH═CH.sub.2                                                       H                                                     S H  Cl CH.sub.3                                                                          1 4-CH.sub.2 SCH.sub.2 CH═CH.sub.2                                                       H                                                     O H  Cl CH.sub.3                                                                          1 4-CH.sub.2 SCH.sub.2 CH═CH.sub.2                                                       H                                                     S F  Cl CH.sub.3                                                                          1 4-CH.sub.2 SCH.sub.2 CH═CH.sub.2                                                       H                                                     O F  Cl CH.sub.3                                                                          1 4-CH.sub.2 SCH.sub.2 CH═CH.sub.2                                                       H                                                     S H  F  H  1 4-CO.sub.2 H                                                                               H                                                     O H  F  H  1 4-CO.sub. 2 H                                                                              H                                                     S F  F  H  1 4-CO.sub.2 H                                                                               H                                                     O F  F  H  1 4-CO.sub.2 H                                                                               H                                                     S H  Cl H  1 4-CO.sub.2 H                                                                               H                                                     O H  Cl H  1 4-CO.sub.2 H                                                                               H                                                     S F  Cl H  1 4-CO.sub.2 H                                                                               H                                                     O F  Cl H  1 4-CO.sub.2 H                                                                               H                                                     S H  F  CH.sub.3                                                                          1 4-CO.sub.2 H                                                                               H                                                     O H  F  CH.sub.3                                                                          1 4-CO.sub.2 H                                                                               H                                                     S F  F  CH.sub.3                                                                          1 4-CO.sub.2 H                                                                               H                                                     O F  F  CH.sub.3                                                                          1 4-CO.sub.2 H                                                                               H                                                     S H  Cl CH.sub.3                                                                          1 4-CO.sub.2 H                                                                               H                                                     O H  Cl CH.sub.3                                                                          1 4-CO.sub.2 H                                                                               H                                                     S F  Cl CH.sub.3                                                                          1 4-CO.sub.2 H                                                                               H                                                     O F  Cl CH.sub.3                                                                          1 4-CO.sub.2 H                                                                               H                                                     S H  F  H  0 H           CO.sub.2 CH.sub.3                                     O H  F  H  0 H           CO.sub.2 CH.sub.3                                     S F  F  H  0 H           CO.sub.2 CH.sub.3                                     O F  F  H  0 H           CO.sub.2 CH.sub.3                                     S H  Cl H  0 H           CO.sub.2 CH.sub.3                                     O H  Cl H  0 H           CO.sub.2 CH.sub.3                                     S F  Cl H  0 H           CO.sub.2 CH.sub.3                                     O F  Cl H  0 H           CO.sub.2 CH.sub.3                                     S H  F  CH.sub.3                                                                          0 H           CO.sub.2 CH.sub.3                                     O H  F  CH.sub.3                                                                          0 H           CO.sub.2 CH.sub.3                                     S F  F  CH.sub.3                                                                          0 H           CO.sub.2 CH.sub.3                                     O F  F  CH.sub.3                                                                          0 H           CO.sub.2 CH.sub.3                                     S H  Cl CH.sub.3                                                                          0 H           CO.sub.2 CH.sub.3                                     O H  Cl CH.sub.3                                                                          0 H           CO.sub.2 CH.sub.3                                     S F  Cl CH.sub.3                                                                          0 H           CO.sub.2 CH.sub.3                                     O F  Cl CH.sub.3                                                                          0 H           CO.sub.2 CH.sub.3                                     S H  F  H  0 H           CO.sub.2 CH.sub.2 CH.sub.3                            O H  F  H  0 H           CO.sub.2 CH.sub.2 CH.sub.3                            S F  F  H  0 H           CO.sub.2 CH.sub.2 CH.sub.3                            O F  F  H  0 H           CO.sub.2 CH.sub.2 CH.sub.3                            S H  Cl H  0 H           CO.sub.2 CH.sub.2 CH.sub.3                            O H  Cl H  0 H           CO.sub.2 CH.sub.2 CH.sub.3                            S F  Cl H  0 H           CO.sub.2 CH.sub.2 CH.sub.3                            O F  Cl H  0 H           CO.sub.2 CH.sub.2 CH.sub.3                            S H  F  CH.sub.3                                                                          0 H           CO.sub.2 CH.sub.2 CH.sub.3                            O H  F  CH.sub.3                                                                          0 H           CO.sub.2 CH.sub.2 CH.sub.3                            S F  F  CH.sub.3                                                                          0 H           CO.sub.2 CH.sub.2 CH.sub.3                            O F  F  CH.sub.3                                                                          0 H           CO.sub.2 CH.sub.2 CH.sub.3                            S H  Cl CH.sub.3                                                                          0 H           CO.sub.2 CH.sub.2 CH.sub.3                            O H  Cl CH.sub.3                                                                          0 H           CO.sub.2 CH.sub.2 CH.sub.3                            S F  Cl CH.sub.3                                                                          0 H           CO.sub.2 CH.sub.2 CH.sub.3                            O F  Cl CH.sub.3                                                                          0 H           CO.sub.2 CH.sub.2 CH.sub.3                            S H  F  H  0 H           CO.sub.2 (CH.sub.2).sub.2 CH.sub.3                    O H  F  H  0 H           CO.sub.2 (CH.sub.2).sub.2 CH.sub.3                    S F  F  H  0 H           CO.sub.2 (CH.sub.2).sub.2 CH.sub.3                    O F  F  H  0 H           CO.sub.2 (CH.sub.2).sub.2 CH.sub.3                    S H  Cl H  0 H           CO.sub.2 (CH.sub.2).sub.2 CH.sub.3                    O H  Cl H  0 H           CO.sub.2 (CH.sub.2).sub.2 CH.sub.3                    S F  Cl H  0 H           CO.sub.2 (CH.sub.2).sub.2 CH.sub.3                    O F  Cl H  0 H           CO.sub.2 (CH.sub.2).sub.2 CH.sub.3                    S H  F  CH.sub.3                                                                          0 H           CO.sub.2 (CH.sub.2).sub.2 CH.sub.3                    O H  F  CH.sub.3                                                                          0 H           CO.sub.2 (CH.sub.2).sub.2 CH.sub.3                    S F  F  CH.sub.3                                                                          0 H           CO.sub.2 (CH.sub.2).sub.2 CH.sub.3                    O F  F  CH.sub.3                                                                          0 H           CO.sub.2 (CH.sub.2).sub.2 CH.sub.3                    S H  Cl CH.sub.3                                                                          0 H           CO.sub.2 (CH.sub.2).sub.2 CH.sub.3                    O H  Cl CH.sub.3                                                                          0 H           CO.sub.2 (CH.sub.2).sub.2 CH.sub.3                    S F  Cl CH.sub.3                                                                          0 H           CO.sub.2 (CH.sub.2).sub.2 CH.sub.3                    O F  Cl CH.sub.3                                                                          0 H           CO.sub.2 (CH.sub.2).sub.2 CH.sub.3                    S H  F  H  0 H           CO.sub.2 CH(CH.sub.3).sub.2                           O H  F  H  0 H           CO.sub.2 CH(CH.sub.3).sub.2                           S F  F  H  0 H           CO.sub.2 CH(CH.sub.3).sub.2                           O F  F  H  0 H           CO.sub.2 CH(CH.sub.3).sub.2                           S H  Cl H  0 H           CO.sub.2 CH(CH.sub.3).sub.2                           O H  Cl H  0 H           CO.sub.2 CH(CH.sub.3).sub.2                           S F  Cl H  0 H           CO.sub.2 CH(CH.sub.3).sub.2                           O F  Cl H  0 H           CO.sub.2 CH(CH.sub.3).sub.2                           S H  F  CH.sub.3                                                                          0 H           CO.sub.2 CH(CH.sub.3).sub.2                           O H  F  CH.sub.3                                                                          0 H           CO.sub.2 CH(CH.sub.3).sub.2                           S F  F  CH.sub.3                                                                          0 H           CO.sub.2 CH(CH.sub.3).sub.2                           O F  F  CH.sub.3                                                                          0 H           CO.sub.2 CH(CH.sub.3).sub.2                           S H  Cl CH.sub.3                                                                          0 H           CO.sub.2 CH(CH.sub.3).sub.2                           O H  Cl CH.sub.3                                                                          0 H           CO.sub.2 CH(CH.sub.3).sub.2                           S F  Cl CH.sub.3                                                                          0 H           CO.sub.2 CH(CH.sub.3).sub.2                           O F  Cl CH.sub.3                                                                          0 H           CO.sub.2 CH(CH.sub.3).sub.2                           S H  F  H  0 H           CO.sub.2 (CH.sub.2).sub.3 CH.sub.3                    O H  F  H  0 H           CO.sub.2 (CH.sub.2).sub.3 CH.sub.3                    S F  F  H  0 H           CO.sub.2 (CH.sub.2).sub.3 CH.sub.3                    O F  F  H  0 H           CO.sub.2 (CH.sub.2).sub.3 CH.sub.3                    S H  Cl H  0 H           CO.sub.2 (CH.sub.2).sub.3 CH.sub.3                    O H  Cl H  0 H           CO.sub.2 (CH.sub.2).sub.3 CH.sub.3                    S F  Cl H  0 H           CO.sub.2 (CH.sub.2).sub.3 CH.sub.3                    O F  Cl H  0 H           CO.sub.2 (CH.sub.2).sub.3 CH.sub.3                    S H  F  CH.sub.3                                                                          0 H           CO.sub.2 (CH.sub.2).sub.3 CH.sub.3                    O H  F  CH.sub.3                                                                          0 H           CO.sub.2 (CH.sub.2).sub.3 CH.sub.3                    S F  F  CH.sub.3                                                                          0 H           CO.sub.2 (CH.sub.2).sub.3 CH.sub.3                    O F  F  CH.sub.3                                                                          0 H           CO.sub.2 (CH.sub.2).sub.3 CH.sub.3                    S H  Cl CH.sub.3                                                                          0 H           CO.sub.2 (CH.sub.2).sub.3 CH.sub.3                    O H  Cl CH.sub.3                                                                          0 H           CO.sub.2 (CH.sub.2).sub.3 CH.sub.3                    S F  Cl CH.sub.3                                                                          0 H           CO.sub.2 (CH.sub.2).sub.3 CH.sub.3                    O F  Cl CH.sub.3                                                                          0 H           CO.sub.2 (CH.sub.2).sub.3 CH.sub.3                    S H  F  H  0 H           CO.sub.2 (CH.sub.2).sub.2 OCH.sub.3                   O H  F  H  0 H           CO.sub.2 (CH.sub.2).sub.2 OCH.sub.3                   S F  F  H  0 H           CO.sub.2 (CH.sub.2).sub.2 OCH.sub.3                   O F  F  H  0 H           CO.sub.2 (CH.sub.2).sub.2 OCH.sub.3                   S H  Cl H  0 H           CO.sub.2 (CH.sub.2).sub.2 OCH.sub.3                   O H  Cl H  0 H           CO.sub.2 (CH.sub.2).sub.2 OCH.sub.3                   S F  Cl H  0 H           CO.sub.2 (CH.sub.2).sub.2 OCH.sub.3                   O F  Cl H  0 H           CO.sub.2 (CH.sub.2).sub.2 OCH.sub.3                   S H  F  CH.sub.3                                                                          0 H           CO.sub.2 (CH.sub.2).sub.2 OCH.sub.3                   O H  F  CH.sub.3                                                                          0 H           CO.sub.2 (CH.sub.2).sub.2 OCH.sub.3                   S F  F  CH.sub.3                                                                          0 H           CO.sub.2 (CH.sub.2).sub.2 OCH.sub.3                   O F  F  CH.sub.3                                                                          0 H           CO.sub.2 (CH.sub.2).sub.2 OCH.sub.3                   S H  Cl CH.sub.3                                                                          0 H           CO.sub.2 (CH.sub.2).sub.2 OCH.sub.3                   O H  Cl CH.sub.3                                                                          0 H           CO.sub.2 (CH.sub.2).sub.2 OCH.sub.3                   S F  Cl CH.sub.3                                                                          0 H           CO.sub.2 (CH.sub.2).sub.2 OCH.sub.3                   O F  Cl CH.sub.3                                                                          0 H           CO.sub.2 (CH.sub.2).sub.2 OCH.sub.3                   S H  F  H  0 H           CO.sub.2 (CH.sub.2).sub.2 OCH.sub.2 CH.sub.3          O H  F  H  0 H           CO.sub.2 (CH.sub.2).sub.2 OCH.sub.2 CH.sub.3          S F  F  H  0 H           CO.sub.2 (CH.sub.2).sub.2 OCH.sub.2 CH.sub.3          O F  F  H  0 H           CO.sub.2 (CH.sub.2).sub.2 OCH.sub.2 CH.sub.3          S H  Cl H  0 H           CO.sub.2 (CH.sub.2).sub.2 OCH.sub.2 CH.sub.3          O H  Cl H  0 H           CO.sub.2 (CH.sub.2).sub.2 OCH.sub.2 CH.sub.3          S F  Cl H  0 H           CO.sub.2 (CH.sub.2).sub.2 OCH.sub.2 CH.sub.3          O F  Cl H  0 H           CO.sub.2 (CH.sub.2).sub.2 OCH.sub.2 CH.sub.3          S H  F  CH.sub.3                                                                          0 H           CO.sub.2 (CH.sub.2).sub.2 OCH.sub.2 CH.sub.3          O H  F  CH.sub.3                                                                          0 H           CO.sub.2 (CH.sub.2).sub.2 OCH.sub.2 CH.sub.3          S F  F  CH.sub.3                                                                          0 H           CO.sub.2 (CH.sub.2).sub.2 OCH.sub.2 CH.sub.3          O F  F  CH.sub.3                                                                          0 H           CO.sub.2 (CH.sub.2).sub.2 OCH.sub.2 CH.sub.3          S H  Cl CH.sub. 3                                                                         0 H           CO.sub.2 (CH.sub.2).sub.2 OCH.sub.2 CH.sub.3          O H  Cl CH.sub.3                                                                          0 H           CO.sub.2 (CH.sub.2).sub.2 OCH.sub.2 CH.sub.3          S F  Cl CH.sub.3                                                                          0 H           CO.sub.2 (CH.sub.2).sub.2 OCH.sub.2 CH.sub.3          O F  Cl CH.sub.3                                                                          0 H           CO.sub.2 (CH.sub.2).sub.2 OCH.sub.2 CH.sub.3          S H  F  H  0 4-CH.sub.3  CO.sub.2 CH.sub.3                                     O H  F  H  0 4-CH.sub.3  CO.sub.2 CH.sub.3                                     S F  F  H  0 4-CH.sub.3  CO.sub.2 CH.sub.3                                     O F  F  H  0 4-CH.sub.3  CO.sub.2 CH.sub.3                                     S H  Cl H  0 4-CH.sub.3  CO.sub.2 CH.sub.3                                     O H  Cl H  0 4-CH.sub.3  CO.sub.2 CH.sub.3                                     S F  Cl H  0 4-CH.sub.3  CO.sub.2 CH.sub.3                                     O F  Cl H  0 4-CH.sub.3  CO.sub.2 CH.sub.3                                     S H  F  CH.sub.3                                                                          0 4-CH.sub.3  CO.sub.2 CH.sub.3                                     O H  F  CH.sub.3                                                                          0 4-CH.sub.3  CO.sub.2 CH.sub.3                                     S F  F  CH.sub.3                                                                          0 4-CH.sub.3  CO.sub.2 CH.sub.3                                     O F  F  CH.sub.3                                                                          0 4-CH.sub.3  CO.sub.2 CH.sub.3                                     S H  Cl CH.sub.3                                                                          0 4-CH.sub.3  CO.sub.2 CH.sub.3                                     O H  Cl CH.sub.3                                                                          0 4-CH.sub.3  CO.sub.2 CH.sub.3                                     S F  Cl CH.sub.3                                                                          0 4-CH.sub.3  CO.sub.2 CH.sub.3                                     O F  Cl CH.sub.3                                                                          0 4-CH.sub.3  CO.sub.2 CH.sub.3                                     S H  F  H  0 4-CH.sub.3  CO.sub.2 CH.sub.2 CH.sub.3                            O H  F  H  0 4-CH.sub.3  CO.sub.2 CH.sub.2 CH.sub.3                            S F  F  H  0 4-CH.sub.3  CO.sub.2 CH.sub.2 CH.sub.3                            O F  F  H  0 4-CH.sub.3  CO.sub.2 CH.sub.2 CH.sub.3                            S H  Cl H  0 4-CH.sub.3  CO.sub.2 CH.sub.2 CH.sub.3                            O H  Cl H  0 4-CH.sub.3  CO.sub.2 CH.sub.2 CH.sub.3                            S F  Cl H  0 4-CH.sub.3  CO.sub.2 CH.sub.2 CH.sub.3                            O F  Cl H  0 4-CH.sub.3  CO.sub.2 CH.sub.2 CH.sub.3                            S H  F  CH.sub.3                                                                          0 4-CH.sub.3  CO.sub.2 CH.sub.2 CH.sub.3                            O H  F  CH.sub.3                                                                          0 4-CH.sub.3  CO.sub.2 CH.sub.2 CH.sub.3                            S F  F  CH.sub.3                                                                          0 4-CH.sub.3  CO.sub.2 CH.sub.2 CH.sub.3                            O F  F  CH.sub.3                                                                          0 4-CH.sub.3  CO.sub.2 CH.sub.2 CH.sub.3                            S H  Cl CH.sub.3                                                                          0 4-CH.sub.3  CO.sub.2 CH.sub.2 CH.sub.3                            O H  Cl CH.sub.3                                                                          0 4-CH.sub.3  CO.sub.2 CH.sub.2 CH.sub.3                            S F  Cl CH.sub.3                                                                          0 4-CH.sub.3  CO.sub.2 CH.sub.2 CH.sub.3                            O F  Cl CH.sub.3                                                                          0 4-CH.sub.3  CO.sub.2 CH.sub.2 CH.sub.3                            S H  F  H  0 4-CH.sub.3  CO.sub.2 (CH.sub.2).sub.2 CH.sub.3                    O H  F  H  0 4-CH.sub.3  CO.sub.2 (CH.sub.2).sub.2 CH.sub.3                    S F  F  H  0 4-CH.sub.3  CO.sub.2 (CH.sub.2).sub.2 CH.sub.3                    O F  F  H  0 4-CH.sub.3  CO.sub.2 (CH.sub.2).sub.2 CH.sub.3                    S H  Cl H  0 4-CH.sub.3  CO.sub.2 (CH.sub.2).sub.2 CH.sub.3                    O H  Cl H  0 4-CH.sub.3  CO.sub.2 (CH.sub.2).sub.2 CH.sub.3                    S F  Cl H  0 4-CH.sub.3  CO.sub.2 (CH.sub.2).sub.2 CH.sub.3                    O F  Cl H  0 4-CH.sub.3  CO.sub.2 (CH.sub.2).sub.2 CH.sub.3                    S H  F  CH.sub.3                                                                          0 4-CH.sub.3  CO.sub.2 (CH.sub.2).sub.2 CH.sub.3                    O H  F  CH.sub.3                                                                          0 4-CH.sub.3  CO.sub.2 (CH.sub.2).sub.2 CH.sub.3                    S F  F  CH.sub.3                                                                          0 4-CH.sub.3  CO.sub.2 (CH.sub.2).sub.2 CH.sub.3                    O F  F  CH.sub.3                                                                          0 4-CH.sub.3  CO.sub.2 (CH.sub.2).sub.2 CH.sub.3                    S H  Cl CH.sub.3                                                                          0 4-CH.sub.3  CO.sub.2 (CH.sub.2).sub.2 CH.sub.3                    O H  Cl CH.sub.3                                                                          0 4-CH.sub.3  CO.sub.2 (CH.sub.2).sub.2 CH.sub.3                    S F  Cl CH.sub.3                                                                          0 4-CH.sub.3  CO.sub.2 (CH.sub.2).sub.2 CH.sub.3                    O F  Cl CH.sub.3                                                                          0 4-CH.sub.3  CO.sub.2 (CH.sub.2).sub.2 CH.sub.3                    S H  F  H  0 4-CH.sub.3  CO.sub.2 CH(CH.sub.3).sub.2                           O H  F  H  0 4-CH.sub.3  CO.sub.2 CH(CH.sub.3).sub.2                           S F  F  H  0 4-CH.sub.3  CO.sub.2 CH(CH.sub.3).sub.2                           O F  F  H  0 4-CH.sub.3  CO.sub.2 CH(CH.sub.3).sub.2                           S H  Cl H  0 4-CH.sub.3  CO.sub.2 CH(CH.sub.3).sub.2                           O H  Cl H  0 4-CH.sub.3  CO.sub.2 CH(CH.sub.3).sub.2                           S F  Cl H  0 4-CH.sub.3  CO.sub.2 CH(CH.sub. 3).sub.2                          O F  Cl H  0 4-CH.sub.3  CO.sub.2 CH(CH.sub.3).sub.2                           S H  F  CH.sub.3                                                                          0 4-CH.sub.3  CO.sub.2 CH(CH.sub.3).sub.2                           O H  F  CH.sub.3                                                                          0 4-CH.sub.3  CO.sub.2 CH(CH.sub.3).sub.2                           S F  F  CH.sub.3                                                                          0 4-CH.sub.3  CO.sub.2 CH(CH.sub.3).sub.2                           O F  F  CH.sub.3                                                                          0 4-CH.sub.3  CO.sub.2 CH(CH.sub.3).sub.2                           S H  Cl CH.sub.3                                                                          0 4-CH.sub.3  CO.sub.2 CH(CH.sub.3).sub.2                           O H  Cl CH.sub.3                                                                          0 4-CH.sub.3  CO.sub.2 CH(CH.sub.3).sub.2                           S F  Cl CH.sub.3                                                                          0 4-CH.sub.3  CO.sub.2 CH(CH.sub.3).sub.2                           O F  Cl CH.sub.3                                                                          0 4-CH.sub.3  CO.sub.2 CH(CH.sub.3).sub.2                           S H  F  H  0 4-CH.sub.3  CO.sub.2 (CH.sub.2).sub.3 CH.sub.3                    O H  F  H  0 4-CH.sub.3  CO.sub.2 (CH.sub.2).sub.3 CH.sub.3                    S F  F  H  0 4-CH.sub.3  CO.sub.2 (CH.sub.2).sub.3 CH.sub.3                    O F  F  H  0 4-CH.sub.3  CO.sub.2 (CH.sub.2).sub.3 CH.sub.3                    S H  Cl H  0 4-CH.sub.3  CO.sub.2 (CH.sub.2).sub. 3 CH.sub.3                   O H  Cl H  0 4-CH.sub.3  CO.sub.2 (CH.sub.2).sub.3 CH.sub.3                    S F  Cl H  0 4-CH.sub.3  CO.sub.2 (CH.sub.2).sub.3 CH.sub.3                    O F  Cl H  0 4-CH.sub.3  CO.sub.2 (CH.sub.2).sub.3 CH.sub.3                    S H  F  CH.sub.3                                                                          0 4-CH.sub.3  CO.sub.2 (CH.sub.2).sub.3 CH.sub.3                    O H  F  CH.sub.3                                                                          0 4-CH.sub.3  CO.sub.2 (CH.sub.2).sub.3 CH.sub.3                    S F  F  CH.sub.3                                                                          0 4-CH.sub.3  CO.sub.2 (CH.sub.2).sub.3 CH.sub.3                    O F  F  CH.sub.3                                                                          0 4-CH.sub.3  CO.sub.2 (CH.sub.2).sub.3 CH.sub.3                    S H  Cl CH.sub.3                                                                          0 4-CH.sub.3  CO.sub.2 (CH.sub.2).sub.3 CH.sub.3                    O H  Cl CH.sub.3                                                                          0 4-CH.sub.3  CO.sub.2 (CH.sub.2).sub.3 CH.sub.3                    S F  Cl CH.sub.3                                                                          0 4-CH.sub.3  CO.sub.2 (CH.sub.2).sub.3 CH.sub.3                    O F  Cl CH.sub.3                                                                          0 4-CH.sub.3  CO.sub.2 (CH.sub.2).sub.3 CH.sub.3                    S H  F  H  0 4-CH.sub.3  CO.sub.2 (CH.sub.2).sub.2 OCH.sub.3                   O H  F  H  0 4-CH.sub.3  CO.sub.2 (CH.sub.2).sub.2 OCH.sub.3                   S F  F  H  0 4-CH.sub.3  CO.sub.2 (CH.sub.2).sub.2 OCH.sub.3                   O F  F  H  0 4-CH.sub.3  CO.sub.2 (CH.sub.2).sub.2 OCH.sub.3                   S H  Cl H  0 4-CH.sub.3  CO.sub.2 (CH.sub.3).sub.2 OCH.sub.3                   O H  Cl H  0 4-CH.sub.3  CO.sub.2 (CH.sub.2).sub.2 OCH.sub.3                   S F  Cl H  0 4-CH.sub.3  CO.sub.2 (CH.sub.2).sub.2 OCH.sub.3                   O F  Cl H  0 4-CH.sub.3  CO.sub.2 (CH.sub.2).sub.2 OCH.sub.3                   S H  F  CH.sub.3                                                                          0 4-CH.sub.3  CO.sub.2 (CH.sub.2).sub.2 OCH.sub.3                   O H  F  CH.sub.3                                                                          0 4-CH.sub.3  CO.sub.2 (CH.sub.2).sub.2 OCH.sub.3                   S F  F  CH.sub.3                                                                          0 4-CH.sub.3  CO.sub.2 (CH.sub.2).sub.2 OCH.sub.3                   O F  F  CH.sub.3                                                                          0 4-CH.sub.3  CO.sub.2 (CH.sub.2).sub.2 OCH.sub.3                   S H  Cl CH.sub.3                                                                          0 4-CH.sub.3  CO.sub.2 (CH.sub.2).sub.2 OCH.sub.3                   O H  Cl CH.sub.3                                                                          0 4-CH.sub.3  CO.sub.2 (CH.sub.2).sub.2 OCH.sub.3                   S F  Cl CH.sub.3                                                                          0 4-CH.sub.3  CO.sub.2 (CH.sub.2).sub.2 OCH.sub.3                   O F  Cl CH.sub.3                                                                          0 4-CH.sub.3  CO.sub.2 (CH.sub.2).sub.2 OCH.sub.3                   S H  F  H  0 4-CH.sub.3  CO.sub.2 (CH.sub.2).sub.2 OCH.sub.2 CH.sub.3          O H  F  H  0 4-CH.sub.3  CO.sub.2 (CH.sub.2).sub.2 OCH.sub.2 CH.sub.3          S F  F  H  0 4-CH.sub.3  CO.sub.2 (CH.sub.2).sub.2 OCH.sub.2 CH.sub.3          O F  F  H  0 4-CH.sub.3  CO.sub.2 (CH.sub.2).sub.2 OCH.sub.2 CH.sub.3          S H  Cl H  0 4-CH.sub.3  CO.sub.2 (CH.sub.2).sub.2 OCH.sub.2 CH.sub.3          O H  Cl H  0 4-CH.sub.3  CO.sub.2 (CH.sub.2).sub.2 OCH.sub.2 CH.sub.3          S F  Cl H  0 4-CH.sub.3  CO.sub.2 (CH.sub.2).sub.2 OCH.sub.2 CH.sub.3          O F  Cl H  0 4-CH.sub.3  CO.sub.2 (CH.sub.2).sub.2 OCH.sub.2 CH.sub.3          S H  F  CH.sub.3                                                                          0 4-CH.sub.3  CO.sub.2 (CH.sub.2).sub.2 OCH.sub.2 CH.sub.3          O H  F  CH.sub.3                                                                          0 4-CH.sub.3  CO.sub.2 (CH.sub.2).sub.2 OCH.sub.2 CH.sub.3          S F  F  CH.sub. 3                                                                         0 4-CH.sub.3  CO.sub.2 (CH.sub.2).sub.2 OCH.sub.2 CH.sub.3          O F  F  CH.sub.3                                                                          0 4-CH.sub.3  CO.sub.2 (CH.sub.2).sub.2 OCH.sub.2 CH.sub.3          S H  Cl CH.sub.3                                                                          0 4-CH.sub.3  CO.sub.2 (CH.sub.2).sub.2 OCH.sub.2 CH.sub.3          O H  Cl CH.sub.3                                                                          0 4-CH.sub.3  CO.sub.2 (CH.sub.2).sub.2 OCH.sub.2 CH.sub.3          S F  Cl CH.sub.3                                                                          0 4-CH.sub.3  CO.sub.2 (CH.sub.2).sub.2 OCH.sub.2 CH.sub.3          O F  Cl CH.sub.3                                                                          0 4-CH.sub.3  CO.sub.2 (CH.sub.2).sub.2 OCH.sub.2 CH.sub.3          S H  F  H  0 5-CH.sub.3  CO.sub.2 CH.sub.3                                     O H  F  H  0 5-CH.sub.3  CO.sub.2 CH.sub.3                                     S F  F  H  0 5-CH.sub.3  CO.sub.2 CH.sub.3                                     O F  F  H  0 5-CH.sub.3  CO.sub.2 CH.sub.3                                     S H  Cl H  0 5-CH.sub.3  CO.sub.2 CH.sub.3                                     O H  Cl H  0 5-CH.sub.3  CO.sub.2 CH.sub.3                                     S F  Cl H  0 5-CH.sub.3  CO.sub.2 CH.sub.3                                     O F  Cl H  0 5-CH.sub.3  CO.sub.2 CH.sub.3                                     S H  F  CH.sub.3                                                                          0 5-CH.sub.3  CO.sub.2 CH.sub.3                                     O H  F  CH.sub.3                                                                          0 5-CH.sub.3  CO.sub.2 CH.sub.3                                     S F  F  CH.sub.3                                                                          0 5-CH.sub.3  CO.sub.2 CH.sub.3                                     O F  F  CH.sub.3                                                                          0 5-CH.sub.3  CO.sub.2 CH.sub.3                                     S H  Cl CH.sub.3                                                                          0 5-CH.sub.3  CO.sub.2 CH.sub.3                                     O H  Cl CH.sub.3                                                                          0 5-CH.sub.3  CO.sub.2 CH.sub.3                                     S F  Cl CH.sub.3                                                                          0 5-CH.sub.3  CO.sub.2 CH.sub.3                                     O F  Cl CH.sub.3                                                                          0 5-CH.sub.3  CO.sub.2 CH.sub.3                                     S H  F  H  0 5-CH.sub.3  CO.sub.2 CH.sub.2 CH.sub.3                            O H  F  H  0 5-CH.sub.3  CO.sub.2 CH.sub.2 CH.sub.3                            S F  F  H  0 5-CH.sub.3  CO.sub.2 CH.sub.2 CH.sub.3                            O F  F  H  0 5-CH.sub.3  CO.sub.2 CH.sub.2 CH.sub.3                            S H  Cl H  0 5-CH.sub.3  CO.sub.2 CH.sub.2 CH.sub.3                            O H  Cl H  0 5-CH.sub.3  CO.sub.2 CH.sub.2 CH.sub.3                            S F  Cl H  0 5-CH.sub.3  CO.sub.2 CH.sub.2 CH.sub.3                            O F  Cl H  0 5-CH.sub.3  CO.sub.2 CH.sub.2 CH.sub.3                            S H  F  CH.sub.3                                                                          0 5-CH.sub.3  CO.sub.2 CH.sub.2 CH.sub.3                            O H  F  CH.sub.3                                                                          0 5-CH.sub.3  CO.sub.2 CH.sub.2 CH.sub.3                            S F  F  CH.sub.3                                                                          0 5-CH.sub.3  CO.sub.2 CH.sub.2 CH.sub.3                            O F  F  CH.sub.3                                                                          0 5-CH.sub.3  CO.sub.2 CH.sub.2 CH.sub.3                            S H  Cl CH.sub.3                                                                          0 5-CH.sub.3  CO.sub.2 CH.sub.2 CH.sub.3                            O H  Cl CH.sub.3                                                                          0 5-CH.sub.3  CO.sub.2 CH.sub.2 CH.sub.3                            S F  Cl CH.sub.3                                                                          0 5-CH.sub.3  CO.sub.2 CH.sub.2 CH.sub.3                            O F  Cl CH.sub.3                                                                          0 5-CH.sub.3  CO.sub.2 CH.sub.2 CH.sub.3                            S H  F  H  0 5-CH.sub.3  CO.sub.2 (CH.sub.2).sub.2 CH.sub.3                    O H  F  H  0 5-CH.sub.3  CO.sub.2 (CH.sub.2).sub.2 CH.sub.3                    S F  F  H  0 5-CH.sub.3  CO.sub.2 (CH.sub.2).sub.2 CH.sub.3                    O F  F  H  0 5-CH.sub.3  CO.sub.2 (CH.sub.2).sub.2 CH.sub.3                    S H  Cl H  0 5-CH.sub.3  CO.sub.2 (CH.sub.2).sub.2 CH.sub.3                    O H  Cl H  0 5-CH.sub.3  CO.sub.2 (CH.sub.2).sub.2 CH.sub.3                    S F  Cl H  0 5-CH.sub.3  CO.sub.2 (CH.sub.2).sub.2 CH.sub.3                    O F  Cl H  0 5-CH.sub.3  CO.sub.2 (CH.sub.2).sub.2 CH.sub.3                    S H  F  CH.sub.3                                                                          0 5-CH.sub.3  CO.sub.2 (CH.sub.2).sub.2 CH.sub.3                    O H  F  CH.sub.3                                                                          0 5-CH.sub.3  CO.sub.2 (CH.sub.2).sub.2 CH.sub.3                    S F  F  CH.sub.3                                                                          0 5-CH.sub.3  CO.sub.2 (CH.sub.2).sub.2 CH.sub.3                    O F  F  CH.sub.3                                                                          0 5-CH.sub.3  CO.sub.2 (CH.sub.2).sub.2 CH.sub.3                    S H  Cl CH.sub.3                                                                          0 5-CH.sub.3  CO.sub.2 (CH.sub.2).sub.2 CH.sub.3                    O H  Cl CH.sub.3                                                                          0 5-CH.sub.3  CO.sub.2 (CH.sub.2).sub.2 CH.sub.3                    S F  Cl CH.sub.3                                                                          0 5-CH.sub.3  CO.sub.2 (CH.sub.2).sub.2 CH.sub.3                    O F  Cl CH.sub.3                                                                          0 5-CH.sub.3  CO.sub.2 (CH.sub.2).sub.2 CH.sub.3                    S H  F  H  0 5-CH.sub.3  CO.sub.2 CH(CH.sub.3).sub.2                           O H  F  H  0 5-CH.sub.3  CO.sub.2 CH(CH.sub.3).sub.2                           S F  F  H  0 5-CH.sub.3  CO.sub.2 CH(CH.sub.3).sub.2                           O F  F  H  0 5-CH.sub.3  CO.sub. 2 CH(CH.sub.3).sub.2                          S H  Cl H  0 5-CH.sub.3  CO.sub.2 CH(CH.sub.3).sub.2                           O H  Cl H  0 5-CH.sub.3  CO.sub.2 CH(CH.sub.3).sub.2                           S F  Cl H  0 5-CH.sub.3  CO.sub.2 CH(CH.sub.3).sub.2                           O F  Cl H  0 5-CH.sub.3  CO.sub.2 CH(CH.sub.3).sub.2                           S H  F  CH.sub.3                                                                          0 5-CH.sub.3  CO.sub.2 CH(CH.sub.3).sub.2                           O H  F  CH.sub.3                                                                          0 5-CH.sub.3  CO.sub.2 CH(CH.sub.3).sub.2                           S F  F  CH.sub.3                                                                          0 5-CH.sub.3  CO.sub.2 CH(CH.sub.3).sub.2                           O F  F  CH.sub.3                                                                          0 5-CH.sub.3  CO.sub.2 CH(CH.sub.3).sub.2                           S H  Cl CH.sub.3                                                                          0 5-CH.sub.3  CO.sub.2 CH(CH.sub.3).sub.2                           O H  Cl CH.sub.3                                                                          0 5-CH.sub.3  CO.sub.2 CH(CH.sub.3).sub.2                           S F  Cl CH.sub.3                                                                          0 5-CH.sub.3  CO.sub.2 CH(CH.sub.3).sub.2                           O F  Cl CH.sub.3                                                                          0 5-CH.sub.3  CO.sub.2 CH(CH.sub.3).sub.2                           S H  F  H  0 5-CH.sub.3  CO.sub.2 (CH.sub.2).sub.3 CH.sub.3                    O H  F  H  0 5-CH.sub.3  CO.sub.2 (CH.sub.2).sub.3 CH.sub.3                    S F  F  H  0 5-CH.sub.3  CO.sub.2 (CH.sub.2).sub.3 CH.sub.3                    O F  F  H  0 5-CH.sub.3  CO.sub.2 (CH.sub.2).sub.3 CH.sub.3                    S H  Cl H  0 5-CH.sub.3  CO.sub.2 (CH.sub.2).sub.3 CH.sub.3                    O H  Cl H  0 5-CH.sub.3  CO.sub.2 (CH.sub.2).sub.3 CH.sub.3                    S F  Cl H  0 5-CH.sub.3  CO.sub.2 (CH.sub.2).sub.3 CH.sub.3                    O F  Cl H  0 5-CH.sub.3  CO.sub.2 (CH.sub.2).sub.3 CH.sub.3                    S H  F  CH.sub.3                                                                          0 5-CH.sub.3  CO.sub.2 (CH.sub.2).sub.3 CH.sub.3                    O H  F  CH.sub.3                                                                          0 5-CH.sub.3  CO.sub.2 (CH.sub.2).sub.3 CH.sub.3                    S F  F  CH.sub.3                                                                          0 5-CH.sub.3  CO.sub.2 (CH.sub.2).sub.3 CH.sub.3                    O F  F  CH.sub.3                                                                          0 5-CH.sub.3  CO.sub.2 (CH.sub.2).sub.3 CH.sub.3                    S H  Cl CH.sub.3                                                                          0 5-CH.sub.3  CO.sub.2 (CH.sub.2).sub.3 CH.sub.3                    O H  Cl CH.sub.3                                                                          0 5-CH.sub.3  CO.sub.2 (CH.sub.2).sub.3 CH.sub.3                    S F  Cl CH.sub.3                                                                          0 5-CH.sub.3  CO.sub.2 (CH.sub.2).sub.3 CH.sub. 3                   O F  Cl CH.sub.3                                                                          0 5-CH.sub.3  CO.sub.2 (CH.sub.2).sub.3 CH.sub.3                    S H  F  H  0 5-CH.sub.3  CO.sub.2 (CH.sub.2).sub.2 OCH.sub.3                   O H  F  H  0 5-CH.sub.3  CO.sub.2 (CH.sub.2).sub.2 OCH.sub.3                   S F  F  H  0 5-CH.sub.3  CO.sub.2 (CH.sub.2).sub.2 OCH.sub.3                   O F  F  H  0 5-CH.sub.3  CO.sub.2 (CH.sub.2).sub.2 OCH.sub.3                   S H  Cl H  0 5-CH.sub.3  CO.sub.2 (CH.sub.2).sub.2 OCH.sub.3                   O H  Cl H  0 5-CH.sub.3  CO.sub.2 (CH.sub.2).sub.2 OCH.sub.3                   S F  Cl H  0 5-CH.sub.3  CO.sub.2 (CH.sub.2).sub.2 OCH.sub.3                   O F  Cl H  0 5-CH.sub.3  CO.sub.2 (CH.sub.2).sub.2 OCH.sub.3                   S H  F  CH.sub.3                                                                          0 5-CH.sub.3  CO.sub.2 (CH.sub.2).sub.2 OCH.sub.3                   O H  F  CH.sub.3                                                                          0 5-CH.sub.3  CO.sub.2 (CH.sub.2).sub.2 OCH.sub.3                   S F  F  CH.sub.3                                                                          0 5-CH.sub.3  CO.sub.2 (CH.sub.2).sub.2 OCH.sub.3                   O F  F  CH.sub.3                                                                          0 5-CH.sub.3  CO.sub.2 (CH.sub.2).sub.2 OCH.sub. 3                  S H  Cl CH.sub.3                                                                          0 5-CH.sub.3  CO.sub.2 (CH.sub.2).sub.2 OCH.sub.3                   O H  Cl CH.sub.3                                                                          0 5-CH.sub.3  CO.sub.2 (CH.sub.2).sub.2 OCH.sub.3                   S F  Cl CH.sub.3                                                                          0 5-CH.sub.3  CO.sub.2 (CH.sub.2).sub.2 OCH.sub.3                   O F  Cl CH.sub.3                                                                          0 5-CH.sub.3  CO.sub.2 (CH.sub.2).sub.2 OCH.sub.3                   S H  F  H  0 5-CH.sub.3  CO.sub.2 (CH.sub.2).sub.2 OCH.sub.2 CH.sub.3          O H  F  H  0 5-CH.sub.3  CO.sub.2 (CH.sub.2).sub.2 OCH.sub.2 CH.sub.3          S F  F  H  0 5-CH.sub.3  CO.sub.2 (CH.sub.2).sub.2 OCH.sub.2 CH.sub.3          O F  F  H  0 5-CH.sub.3  CO.sub.2 (CH.sub.2).sub.2 OCH.sub.2 CH.sub.3          S H  Cl H  0 5-CH.sub.3  CO.sub.2 (CH.sub.2).sub.2 OCH.sub.2 CH.sub.3          O H  Cl H  0 5-CH.sub.3  CO.sub.2 (CH.sub.2).sub.2 OCH.sub.2 CH.sub.3          S F  Cl H  0 5-CH.sub.3  CO.sub.2 (CH.sub.2).sub.2 OCH.sub.2 CH.sub.3          O F  Cl H  0 5-CH.sub.3  CO.sub.2 (CH.sub.2).sub.2 OCH.sub.2 CH.sub. 3         S H  F  CH.sub.3                                                                          0 5-CH.sub.3  CO.sub.2 (CH.sub.2).sub.2 OCH.sub.2 CH.sub.3          O H  F  CH.sub.3                                                                          0 5-CH.sub.3  CO.sub.2 (CH.sub.2).sub.2 OCH.sub.2 CH.sub.3          S F  F  CH.sub.3                                                                          0 5-CH.sub.3  CO.sub.2 (CH.sub.2).sub.2 OCH.sub.2 CH.sub.3          O F  F  CH.sub.3                                                                          0 5-CH.sub.3  CO.sub.2 (CH.sub.2).sub.2 OCH.sub.2 CH.sub.3          S H  Cl CH.sub.3                                                                          0 5-CH.sub.3  CO.sub.2 (CH.sub.2).sub.2 OCH.sub.2 CH.sub.3          O H  Cl CH.sub.3                                                                          0 5-CH.sub.3  CO.sub.2 (CH.sub.2).sub.2 OCH.sub.2 CH.sub.3          S F  Cl CH.sub.3                                                                          0 5-CH.sub.3  CO.sub.2 (CH.sub.2).sub.2 OCH.sub.2 CH.sub.3          O F  Cl CH.sub.3                                                                          0 5-CH.sub.3  CO.sub.2 (CH.sub.2).sub.2 OCH.sub.2 CH.sub.3          S H  F  H  0 4,5-Di-CH.sub.3                                                                            CO.sub.2 CH.sub.3                                     O H  F  H  0 4,5-Di-CH.sub.3                                                                            CO.sub.2 CH.sub.3                                     S F  F  H  0 4,5-Di-CH.sub.3                                                                            CO.sub.2 CH.sub.3                                     O F  F  H  0 4,5-Di-CH.sub.3                                                                            CO.sub.2 CH.sub.3                                     S H  Cl H  0 4,5-Di-CH.sub.3                                                                            CO.sub.2 CH.sub.3                                     O H  Cl H  0 4,5-Di-CH.sub.3                                                                            CO.sub.2 CH.sub.3                                     S F  Cl H  0 4,5-Di-CH.sub.3                                                                            CO.sub.2 CH.sub.3                                     O F  Cl H  0 4,5-Di-CH.sub.3                                                                            CO.sub.2 CH.sub.3                                     S H  F  CH.sub.3                                                                          0 4,5-Di-CH.sub.3                                                                            CO.sub.2 CH.sub.3                                     O H  F  CH.sub.3                                                                          0 4,5-Di-CH.sub.3                                                                            CO.sub.2 CH.sub.3                                     S F  F  CH.sub.3                                                                          0 4,5-Di-CH.sub.3                                                                            CO.sub.2 CH.sub.3                                     O F  F  CH.sub.3                                                                          0 4,5-Di-CH.sub.3                                                                            CO.sub.2 CH.sub.3                                     S H  Cl CH.sub.3                                                                          0 4,5-Di-CH.sub.3                                                                            CO.sub.2 CH.sub.3                                     O H  Cl CH.sub.3                                                                          0 4,5-Di-CH.sub.3                                                                            CO.sub.2 CH.sub.3                                     S F  Cl CH.sub.3                                                                          0 4,5-Di-CH.sub.3                                                                            CO.sub.2 CH.sub.3                                     O F  Cl CH.sub.3                                                                          0 4,5-Di-CH.sub.3                                                                            CO.sub.2 CH.sub.3                                     S H  F  H  0 4,5-Di-CH.sub.3                                                                            CO.sub.2 CH.sub.2 CH.sub.3                            O H  F  H  0 4,5-Di-CH.sub.3                                                                            CO.sub.2 CH.sub.2 CH.sub.3                            S F  F  H  0 4,5-Di-CH.sub.3                                                                            CO.sub.2 CH.sub.2 CH.sub.3                            O F  F  H  0 4,5-Di-CH.sub.3                                                                            CO.sub.2 CH.sub.2 CH.sub.3                            S H  Cl H  0 4,5-Di-CH.sub.3                                                                            CO.sub.2 CH.sub.2 CH.sub.3                            O H  Cl H  0 4,5-Di-CH.sub. 3                                                                           CO.sub.2 CH.sub.2 CH.sub.3                            S F  Cl H  0 4,5-Di-CH.sub.3                                                                            CO.sub.2 CH.sub.2 CH.sub.3                            O F  Cl H  0 4,5-Di-CH.sub.3                                                                            CO.sub.2 CH.sub.2 CH.sub.3                            S H  F  CH.sub.3                                                                          0 4,5-Di-CH.sub.3                                                                            CO.sub.2 CH.sub.2 CH.sub.3                            O H  F  CH.sub.3                                                                          0 4,5-Di-CH.sub.3                                                                            CO.sub.2 CH.sub.2 CH.sub.3                            S F  F  CH.sub.3                                                                          0 4,5-Di-CH.sub.3                                                                            CO.sub.2 CH.sub.2 CH.sub.3                            O F  F  CH.sub.3                                                                          0 4,5-Di-CH.sub.3                                                                            CO.sub.2 CH.sub.2 CH.sub.3                            S H  Cl CH.sub.3                                                                          0 4,5-Di-CH.sub.3                                                                            CO.sub.2 CH.sub.2 CH.sub.3                            O H  Cl CH.sub.3                                                                          0 4,5-Di-CH.sub.3                                                                            CO.sub.2 CH.sub.2 CH.sub.3                            S F  Cl CH.sub.3                                                                          0 4,5-Di-CH.sub.3                                                                            CO.sub.2 CH.sub.2 CH.sub.3                            O F  Cl CH.sub.3                                                                          0 4,5-Di-CH.sub.3                                                                            CO.sub.2 CH.sub.2 CH.sub.3                            S H  F  H  0 4,5-Di-CH.sub.3                                                                            CO.sub.2 (CH.sub.2).sub.2 CH.sub.3                    O H  F  H  0 4,5-Di-CH.sub.3                                                                            CO.sub.2 (CH.sub.2).sub.2 CH.sub.3                    S F  F  H  0 4,5-Di-CH.sub.3                                                                            CO.sub.2 (CH.sub.2).sub.2 CH.sub.3                    O F  F  H  0 4,5-Di-CH.sub.3                                                                            CO.sub.2 (CH.sub. 2).sub.2 CH.sub.3                   S H  Cl H  0 4,5-Di-CH.sub.3                                                                            CO.sub.2 (CH.sub.2).sub.2 CH.sub.3                    O H  Cl H  0 4,5-Di-CH.sub.3                                                                            CO.sub.2 (CH.sub.2).sub.2 CH.sub.3                    S F  Cl H  0 4,5-Di-CH.sub.3                                                                            CO.sub.2 (CH.sub.2).sub.2 CH.sub.3                    O F  Cl H  0 4,5-Di-CH.sub.3                                                                            CO.sub.2 (CH.sub.2).sub.2 CH.sub.3                    S H  F  CH.sub.3                                                                          0 4,5-Di-CH.sub.3                                                                            CO.sub.2 (CH.sub.2).sub.2 CH.sub.3                    O H  F  CH.sub.3                                                                          0 4,5-Di-CH.sub.3                                                                            CO.sub.2 (CH.sub.2).sub.2 CH.sub.3                    S F  F  CH.sub.3                                                                          0 4,5-Di-CH.sub.3                                                                            CO.sub.2 (CH.sub.2).sub.2 CH.sub.3                    O F  F  CH.sub.3                                                                          0 4,5-Di-CH.sub.3                                                                            CO.sub.2 (CH.sub.2).sub.2 CH.sub.3                    S H  Cl CH.sub.3                                                                          0 4,5-Di-CH.sub.3                                                                            CO.sub.2 (CH.sub.2).sub.2 CH.sub.3                    O H  Cl CH.sub.3                                                                          0 4,5-Di-CH.sub.3                                                                            CO.sub.2 (CH.sub.2).sub.2 CH.sub.3                    S F  Cl CH.sub.3                                                                          0 4,5-Di-CH.sub.3                                                                            CO.sub.2 (CH.sub.2).sub.2 CH.sub.3                    O F  Cl CH.sub.3                                                                          0 4,5-Di-CH.sub.3                                                                            CO.sub.2 (CH.sub.2).sub.2 CH.sub.3                    S H  F  H  0 4,5-Di-CH.sub.3                                                                            CO.sub.2 CH(CH.sub.3).sub.2                           O H  F  H  0 4,5-Di-CH.sub.3                                                                            CO.sub.2 CH(CH.sub.3).sub.2                           S F  F  H  0 4,5-Di-CH.sub.3                                                                            CO.sub.2 CH(CH.sub.3).sub.2                           O F  F  H  0 4,5-Di-CH.sub.3                                                                            CO.sub.2 CH(CH.sub.3).sub.2                           S H  Cl H  0 4,5-Di-CH.sub.3                                                                            CO.sub.2 CH(CH.sub.3).sub.2                           O H  Cl H  0 4,5-Di-CH.sub.3                                                                            CO.sub.2 CH(CH.sub.3).sub.2                           S F  Cl H  0 4,5-Di-CH.sub.3                                                                            CO.sub.2 CH(CH.sub.3).sub.2                           O F  Cl H  0 4,5-Di-CH.sub.3                                                                            CO.sub.2 CH(CH.sub.3).sub.2                           S H  F  CH.sub.3                                                                          0 4,5-Di-CH.sub.3                                                                            CO.sub.2 CH(CH.sub.3).sub.2                           O H  F  CH.sub.3                                                                          0 4,5-Di-CH.sub.3                                                                            CO.sub.2 CH(CH.sub.3).sub.2                           S F  F  CH.sub.3                                                                          0 4,5-Di-CH.sub.3                                                                            CO.sub.2 CH(CH.sub.3).sub.2                           O F  F  CH.sub.3                                                                          0 4,5-Di-CH.sub.3                                                                            CO.sub.2 CH(CH.sub.3).sub.2                           S H  Cl CH.sub.3                                                                          0 4,5-Di-CH.sub.3                                                                            CO.sub.2 CH(CH.sub.3).sub.2                           O H  Cl CH.sub.3                                                                          0 4,5-Di-CH.sub.3                                                                            CO.sub.2 CH(CH.sub.3).sub.2                           S F  Cl CH.sub.3                                                                          0 4,5-Di-CH.sub.3                                                                            CO.sub.2 CH(CH.sub.3).sub.2                           O F  Cl CH.sub.3                                                                          0 4,5-Di-CH.sub.3                                                                            CO.sub.2 CH(CH.sub.3).sub.2                           S H  F  H  0 4,5-Di-CH.sub.3                                                                            CO.sub.2 (CH.sub.2).sub.3 CH.sub.3                    O H  F  H  0 4,5-Di-CH.sub.3                                                                            CO.sub.2 (CH.sub.2).sub.3 CH.sub.3                    S F  F  H  0 4,5-Di-CH.sub.3                                                                            CO.sub.2 (CH.sub.2).sub.3 CH.sub.3                    O F  F  H  0 4,5-Di-CH.sub.3                                                                            CO.sub.2 (CH.sub.2).sub.3 CH.sub.3                    S H  Cl H  0 4,5-Di-CH.sub.3                                                                            CO.sub.2 (CH.sub.2).sub.3 CH.sub.3                    O H  Cl H  0 4,5-Di-CH.sub.3                                                                            CO.sub.2 (CH.sub.2).sub.3 CH.sub.3                    S F  Cl H  0 4,5-Di-CH.sub.3                                                                            CO.sub.2 (CH.sub.2).sub.3 CH.sub.3                    O F  Cl H  0 4,5-Di-CH.sub.3                                                                            CO.sub.2 (CH.sub.2).sub.3 CH.sub.3                    S H  F  CH.sub.3                                                                          0 4,5-Di-CH.sub.3                                                                            CO.sub.2 (CH.sub.2).sub.3 CH.sub.3                    O H  F  CH.sub.3                                                                          0 4,5-Di-CH.sub.3                                                                            CO.sub.2 (CH.sub.2).sub.3 CH.sub.3                    S F  F  CH.sub.3                                                                          0 4,5-Di-CH.sub.3                                                                            CO.sub.2 (CH.sub.2).sub.3 CH.sub.3                    O F  F  CH.sub.3                                                                          0 4,5-Di-CH.sub.3                                                                            CO.sub.2 (CH.sub.2).sub.3 CH.sub.3                    S H  Cl CH.sub.3                                                                          0 4,5-Di-CH.sub. 3                                                                           CO.sub.2 (CH.sub.2).sub.3 CH.sub.3                    O H  Cl CH.sub.3                                                                          0 4,5-Di-CH.sub.3                                                                            CO.sub.2 (CH.sub.2).sub.3 CH.sub.3                    S F  Cl CH.sub.3                                                                          0 4,5-Di-CH.sub.3                                                                            CO.sub.2 (CH.sub.2).sub.3 CH.sub.3                    O F  Cl CH.sub.3                                                                          0 4,5-Di-CH.sub.3                                                                            CO.sub.2 (CH.sub.2).sub.3 CH.sub.3                    S H  F  H  0 4,5-Di-CH.sub.3                                                                            CO.sub.2 (CH.sub.2).sub.2 OCH.sub.3                   O H  F  H  0 4,5-Di-CH.sub.3                                                                            CO.sub.2 (CH.sub.2).sub.2 OCH.sub.3                   S F  F  H  0 4,5-Di-CH.sub.3                                                                            CO.sub.2 (CH.sub.2).sub.2 OCH.sub.3                   O F  F  H  0 4,5-Di-CH.sub.3                                                                            CO.sub.2 (CH.sub.2).sub.2 OCH.sub.3                   S H  Cl H  0 4,5-Di-CH.sub.3                                                                            CO.sub.2 (CH.sub.2).sub.2 OCH.sub.3                   O H  Cl H  0 4,5-Di-CH.sub.3                                                                            CO.sub.2 (CH.sub.2).sub.2 OCH.sub.3                   S F  Cl H  0 4,5-Di-CH.sub.3                                                                            CO.sub.2 (CH.sub.2).sub.2 OCH.sub.3                   O F  Cl H  0 4,5-Di-CH.sub.3                                                                            CO.sub.2 (CH.sub.2).sub.2 OCH.sub.3                   S H  F  CH.sub.3                                                                          0 4,5-Di-CH.sub.3                                                                            CO.sub.2 (CH.sub.2).sub.2 OCH.sub.3                   O H  F  CH.sub.3                                                                          0 4,5-Di-CH.sub. 3                                                                           CO.sub.2 (CH.sub.2).sub.2 OCH.sub.3                   S F  F  CH.sub.3                                                                          0 4,5-Di-CH.sub.3                                                                            CO.sub.2 (CH.sub.2).sub.2 OCH.sub.3                   O F  F  CH.sub.3                                                                          0 4,5-Di-CH.sub.3                                                                            CO.sub.2 (CH.sub.2).sub.2 OCH.sub.3                   S H  Cl CH.sub.3                                                                          0 4,5-Di-CH.sub.3                                                                            CO.sub.2 (CH.sub.2).sub.2 OCH.sub.3                   O H  Cl CH.sub.3                                                                          0 4,5-Di-CH.sub.3                                                                            CO.sub.2 (CH.sub.2).sub.2 OCH.sub.3                   S F  Cl CH.sub.3                                                                          0 4,5-Di-CH.sub.3                                                                            CO.sub.2 (CH.sub.2).sub.2 OCH.sub.3                   O F  Cl CH.sub.3                                                                          0 4,5-Di-CH.sub.3                                                                            CO.sub.2 (CH.sub.2).sub.2 OCH.sub.3                   S H  F  H  0 4,5-Di-CH.sub.3                                                                            CO.sub.2 (CH.sub.2).sub.2 OCH.sub.2 CH.sub.3          O H  F  H  0 4,5-Di-CH.sub.3                                                                            CO.sub.2 (CH.sub.2).sub.2 OCH.sub.2 CH.sub.3          S F  F  H  0 4,5-Di-CH.sub.3                                                                            CO.sub.2 (CH.sub.2).sub.2 OCH.sub.2 CH.sub.3          O F  F  H  0 4,5-Di-CH.sub.3                                                                            CO.sub.2 (CH.sub.2).sub.2 OCH.sub.2 CH.sub.3          S H  Cl H  0 4,5-Di-CH.sub.3                                                                            CO.sub.2 (CH.sub.2).sub.2 OCH.sub.2 CH.sub.3          O H  Cl H  0 4,5-Di-CH.sub.3                                                                            CO.sub.2 (CH.sub. 2).sub.2 OCH.sub.2 CH.sub.3         S F  Cl H  0 4,5-Di-CH.sub.3                                                                            CO.sub.2 (CH.sub.2).sub.2 OCH.sub.2 CH.sub.3          O F  Cl H  0 4,5-Di-CH.sub.3                                                                            CO.sub.2 (CH.sub.2).sub.2 OCH.sub.2 CH.sub.3          S H  F  CH.sub.3                                                                          0 4,5-Di-CH.sub.3                                                                            CO.sub.2 (CH.sub.2).sub.2 OCH.sub.2 CH.sub.3          O H  F  CH.sub.3                                                                          0 4,5-Di-CH.sub.3                                                                            CO.sub.2 (CH.sub.2).sub.2 OCH.sub.2 CH.sub.3          S F  F  CH.sub.3                                                                          0 4,5-Di-CH.sub.3                                                                            CO.sub.2 (CH.sub.2).sub.2 OCH.sub.2 CH.sub.3          O F  F  CH.sub.3                                                                          0 4,5-Di-CH.sub.3                                                                            CO.sub.2 (CH.sub.2).sub.2 OCH.sub.2 CH.sub.3          S H  Cl CH.sub.3                                                                          0 4,5-Di-CH.sub.3                                                                            CO.sub.2 (CH.sub.2).sub.2 OCH.sub.2 CH.sub.3          O H  Cl CH.sub.3                                                                          0 4,5-Di-CH.sub.3                                                                            CO.sub.2 (CH.sub.2).sub.2 OCH.sub.2 CH.sub.3          S F  Cl CH.sub.3                                                                          0 4,5-Di-CH.sub.3                                                                            CO.sub.2 (CH.sub.2).sub.2 OCH.sub.2 CH.sub.3          O F  Cl CH.sub.3                                                                          0 4,5-Di-CH.sub.3                                                                            CO.sub.2 (CH.sub.2).sub.2 OCH.sub.2 CH.sub.3          S H  F  H  1 H           CO.sub.2 CH.sub.3                                     O H  F  H  1 H           CO.sub.2 CH.sub.3                                     S F  F  H  1 H           CO.sub.2 CH.sub.3                                     O F  F  H  1 H           CO.sub.2 CH.sub.3                                     S H  Cl H  1 H           CO.sub.2 CH.sub.3                                     O H  Cl H  1 H           CO.sub.2 CH.sub.3                                     S F  Cl H  1 H           CO.sub.2 CH.sub.3                                     O F  Cl H  1 H           CO.sub.2 CH.sub.3                                     S H  F  CH.sub.3                                                                          1 H           CO.sub.2 CH.sub.3                                     O H  F  CH.sub.3                                                                          1 H           CO.sub.2 CH.sub.3                                     S F  F  CH.sub.3                                                                          1 H           CO.sub.2 CH.sub.3                                     O F  F  CH.sub.3                                                                          1 H           CO.sub.2 CH.sub.3                                     S H  Cl CH.sub.3                                                                          1 H           CO.sub.2 CH.sub.3                                     O H  Cl CH.sub.3                                                                          1 H           CO.sub.2 CH.sub.3                                     S F  Cl CH.sub.3                                                                          1 H           CO.sub.2 CH.sub.3                                     O F  Cl CH.sub.3                                                                          1 H           CO.sub.2 CH.sub.3                                     S H  F  H  1 H           CO.sub.2 CH.sub.2 CH.sub.3                            O H  F  H  1 H           CO.sub.2 CH.sub.2 CH.sub.3                            S F  F  H  1 H           CO.sub.2 CH.sub.2 CH.sub.3                            O F  F  H  1 H           CO.sub.2 CH.sub.2 CH.sub. 3                           S H  Cl H  1 H           CO.sub.2 CH.sub.2 CH.sub.3                            O H  Cl H  1 H           CO.sub.2 CH.sub.2 CH.sub.3                            S F  Cl H  1 H           CO.sub.2 CH.sub.2 CH.sub.3                            O F  Cl H  1 H           CO.sub.2 CH.sub.2 CH.sub.3                            S H  F  CH.sub.3                                                                          1 H           CO.sub.2 CH.sub.2 CH.sub.3                            O H  F  CH.sub.3                                                                          1 H           CO.sub.2 CH.sub.2 CH.sub.3                            S F  F  CH.sub.3                                                                          1 H           CO.sub.2 CH.sub.2 CH.sub.3                            O F  F  CH.sub.3                                                                          1 H           CO.sub.2 CH.sub.2 CH.sub.3                            S H  Cl CH.sub.3                                                                          1 H           CO.sub.2 CH.sub.2 CH.sub.3                            O H  Cl CH.sub.3                                                                          1 H           CO.sub.2 CH.sub.2 CH.sub.3                            S F  Cl CH.sub.3                                                                          1 H           CO.sub.2 CH.sub.2 CH.sub.3                            O F  Cl CH.sub.3                                                                          1 H           CO.sub.2 CH.sub.2 CH.sub.3                            S H  F  H  1 H           CO.sub.2 (CH.sub.2).sub.2 CH.sub.3                    O H  F  H  1 H           CO.sub.2 (CH.sub.2).sub.2 CH.sub.3                    S F  F  H  1 H           CO.sub.2 (CH.sub.2).sub.2 CH.sub.3                    O F  F  H  1 H           CO.sub.2 (CH.sub.2).sub.2 CH.sub.3                    S H  Cl H  1 H           CO.sub.2 (CH.sub.2).sub.2 CH.sub.3                    O H  Cl H  1 H           CO.sub.2 (CH.sub.2).sub.2 CH.sub.3                    S F  Cl H  1 H           CO.sub.2 (CH.sub.2).sub.2 CH.sub.3                    O F  Cl H  1 H           CO.sub.2 (CH.sub.2).sub.2 CH.sub.3                    S H  F  CH.sub.3                                                                          1 H           CO.sub.2 (CH.sub.2).sub.2 CH.sub.3                    O H  F  CH.sub.3                                                                          1 H           CO.sub.2 (CH.sub.2).sub.2 CH.sub.3                    S F  F  CH.sub.3                                                                          1 H           CO.sub.2 (CH.sub.2).sub.2 CH.sub.3                    O F  F  CH.sub.3                                                                          1 H           CO.sub.2 (CH.sub.2).sub.2 CH.sub.3                    S H  Cl CH.sub.3                                                                          1 H           CO.sub.2 (CH.sub.2).sub.2 CH.sub.3                    O H  Cl CH.sub.3                                                                          1 H           CO.sub.2 (CH.sub.2).sub.2 CH.sub.3                    S F  Cl CH.sub.3                                                                          1 H           CO.sub.2 (CH.sub.2).sub.2 CH.sub.3                    O F  Cl CH.sub.3                                                                          1 H           CO.sub.2 (CH.sub.2).sub.2 CH.sub.3                    S H  F  H  1 H           CO.sub.2 CH(CH.sub.3).sub.2                           O H  F  H  1 H           CO.sub.2 CH(CH.sub.3).sub.2                           S F  F  H  1 H           CO.sub.2 CH(CH.sub.3).sub.2                           O F  F  H  1 H           CO.sub.2 CH(CH.sub.3).sub.2                           S H  Cl H  1 H           CO.sub.2 CH(CH.sub.3).sub.2                           O H  Cl H  1 H           CO.sub.2 CH(CH.sub.3).sub.2                           S F  Cl H  1 H           CO.sub.2 CH(CH.sub.3).sub.2                           O F  Cl H  1 H           CO.sub.2 CH(CH.sub.3).sub.2                           S H  F  CH.sub.3                                                                          1 H           CO.sub.2 CH(CH.sub.3).sub.2                           O H  F  CH.sub.3                                                                          1 H           CO.sub.2 CH(CH.sub.3).sub.2                           S F  F  CH.sub.3                                                                          1 H           CO.sub.2 CH(CH.sub.3).sub.2                           O F  F  CH.sub.3                                                                          1 H           CO.sub.2 CH(CH.sub.3).sub.2                           S H  Cl CH.sub.3                                                                          1 H           CO.sub.2 CH(CH.sub.3).sub.2                           O H  Cl CH.sub.3                                                                          1 H           CO.sub.2 CH(CH.sub.3).sub.2                           S F  Cl CH.sub.3                                                                          1 H           CO.sub.2 CH(CH.sub.3).sub.2                           O F  Cl CH.sub.3                                                                          1 H           CO.sub.2 CH(CH.sub.3).sub.2                           S H  F  H  1 H           CO.sub.2 (CH.sub.2).sub.3 CH.sub.3                    O H  F  H  1 H           CO.sub.2 (CH.sub.2).sub.3 CH.sub.3                    S F  F  H  1 H           CO.sub.2 (CH.sub.2).sub.3 CH.sub.3                    O F  F  H  1 H           CO.sub.2 (CH.sub.2).sub.3 CH.sub.3                    S H  Cl H  1 H           CO.sub.2 (CH.sub.2).sub.3 CH.sub.3                    O H  Cl H  1 H           CO.sub.2 (CH.sub.2).sub.3 CH.sub.3                    S F  Cl H  1 H           CO.sub.2 (CH.sub.2).sub.3 CH.sub.3                    O F  Cl H  1 H           CO.sub.2 (CH.sub.2).sub.3 CH.sub.3                    S H  F  CH.sub.3                                                                          1 H           CO.sub.2 (CH.sub.2).sub.3 CH.sub.3                    O H  F  CH.sub.3                                                                          1 H           CO.sub.2 (CH.sub.2).sub.3 CH.sub.3                    S F  F  CH.sub.3                                                                          1 H           CO.sub.2 (CH.sub.2).sub.3 CH.sub.3                    O F  F  CH.sub.3                                                                          1 H           CO.sub.2 (CH.sub.2).sub.3 CH.sub.3                    S H  Cl CH.sub.3                                                                          1 H           CO.sub.2 (CH.sub.2).sub.3 CH.sub.3                    O H  Cl CH.sub.3                                                                          1 H           CO.sub.2 (CH.sub.2).sub.3 CH.sub.3                    S F  Cl CH.sub.3                                                                          1 H           CO.sub.2 (CH.sub.2).sub.3 CH.sub.3                    O F  Cl CH.sub.3                                                                          1 H           CO.sub.2 (CH.sub.2).sub.3 CH.sub.3                    S H  F  H  1 H           CO.sub.2 (CH.sub.2).sub.2 OCH.sub.3                   O H  F  H  1 H           CO.sub.2 (CH.sub.2).sub.2 OCH.sub.3                   S F  F  H  1 H           CO.sub.2 (CH.sub.2).sub.2 OCH.sub.3                   O F  F  H  1 H           CO.sub.2 (CH.sub.2).sub.2 OCH.sub.3                   S H  Cl H  1 H           CO.sub.2 (CH.sub.2).sub.2 OCH.sub.3                   O H  Cl H  1 H           CO.sub.2 (CH.sub.2).sub.2 OCH.sub.3                   S F  Cl H  1 H           CO.sub.2 (CH.sub.2).sub.2 OCH.sub.3                   O F  Cl H  1 H           CO.sub.2 (CH.sub.2).sub.2 OCH.sub.3                   S H  F  CH.sub.3                                                                          1 H           CO.sub.2 (CH.sub.2).sub.2 OCH.sub.3                   O H  F  CH.sub.3                                                                          1 H           CO.sub.2 (CH.sub.2).sub.2 OCH.sub.3                   S F  F  CH.sub.3                                                                          1 H           CO.sub.2 (CH.sub.2).sub.2 OCH.sub.3                   O F  F  CH.sub.3                                                                          1 H           CO.sub.2 (CH.sub.2).sub.2 OCH.sub.3                   S H  Cl CH.sub.3                                                                          1 H           CO.sub.2 (CH.sub.2 ).sub.2 OCH.sub.3                  O H  Cl CH.sub.3                                                                          1 H           CO.sub.2 (CH.sub.2).sub.2 OCH.sub.3                   S F  Cl CH.sub.3                                                                          1 H           CO.sub.2 (CH.sub.2).sub.2 OCH.sub.3                   O F  Cl CH.sub.3                                                                          1 H           CO.sub.2 (CH.sub.2).sub.2 OCH.sub.3                   S H  F  H  1 H           CO.sub.2 (CH.sub.2).sub.2 OCH.sub.2 CH.sub.3          O H  F  H  1 H           CO.sub.2 (CH.sub.2).sub.2 OCH.sub.2 CH.sub.3          S F  F  H  1 H           CO.sub.2 (CH.sub.2).sub.2 OCH.sub.2 CH.sub.3          O F  F  H  1 H           CO.sub.2 (CH.sub.2).sub.2 OCH.sub.2 CH.sub.3          S H  Cl H  1 H           CO.sub.2 (CH.sub.2).sub.2 OCH.sub.2 CH.sub.3          O H  Cl H  1 H           CO.sub.2 (CH.sub.2).sub.2 OCH.sub.2 CH.sub.3          S F  Cl H  1 H           CO.sub.2 (CH.sub.2).sub.2 OCH.sub.2 CH.sub.3          O F  Cl H  1 H           CO.sub.2 (CH.sub.2).sub.2 OCH.sub.2 CH.sub.3          S H  F  CH.sub.3                                                                          1 H           CO.sub.2 (CH.sub.2).sub.2 OCH.sub.2 CH.sub.3          O H  F  CH.sub.3                                                                          1 H           CO.sub.2 (CH.sub.2).sub.2 OCH.sub.2 CH.sub.3          S F  F  CH.sub.3                                                                          1 H           CO.sub.2 (CH.sub.2).sub.2 OCH.sub.2 CH.sub.3          O F  F  CH.sub.3                                                                          1 H           CO.sub.2 (CH.sub.2).sub.2 OCH.sub.2 CH.sub.3          S H  Cl CH.sub.3                                                                          1 H           CO.sub.2 (CH.sub.2).sub.2 OCH.sub.2 CH.sub.3          O H  Cl CH.sub.3                                                                          1 H           CO.sub.2 (CH.sub.2).sub.2 OCH.sub.2 CH.sub.3          S F  Cl CH.sub.3                                                                          1 H           CO.sub.2 (CH.sub.2).sub.2 OCH.sub.2 CH.sub.3          O F  Cl CH.sub.3                                                                          1 H           CO.sub.2 (CH.sub.2).sub.2 OCH.sub.2 CH.sub.3          S H  F  H  1 4-CH.sub.3  CO.sub.2 CH.sub.3                                     O H  F  H  1 4-CH.sub.3  CO.sub.2 CH.sub.3                                     S F  F  H  1 4-CH.sub.3  CO.sub.2 CH.sub.3                                     O F  F  H  1 4-CH.sub.3  CO.sub.2 CH.sub.3                                     S H  Cl H  1 4-CH.sub.3  CO.sub.2 CH.sub.3                                     O H  Cl H  1 4-CH.sub.3  CO.sub.2 CH.sub.3                                     S F  Cl H  1 4-CH.sub.3  CO.sub.2 CH.sub.3                                     O F  Cl H  1 4-CH.sub.3  CO.sub.2 CH.sub.3                                     S H  F  CH.sub.3                                                                          1 4-CH.sub.3  CO.sub.2 CH.sub.3                                     O H  F  CH.sub.3                                                                          1 4-CH.sub.3  CO.sub.2 CH.sub.3                                     S F  F  CH.sub.3                                                                          1 4-CH.sub.3  CO.sub.2 CH.sub.3                                     O F  F  CH.sub.3                                                                          1 4-CH.sub.3  CO.sub.2 CH.sub.3                                     S H  Cl CH.sub.3                                                                          1 4-CH.sub.3  CO.sub.2 CH.sub.3                                     O H  Cl CH.sub.3                                                                          1 4-CH.sub.3  CO.sub.2 CH.sub.3                                     S F  Cl CH.sub.3                                                                          1 4-CH.sub.3  CO.sub.2 CH.sub.3                                     O F  Cl CH.sub.3                                                                          1 4-CH.sub.3  CO.sub.2 CH.sub.3                                     S H  F  H  1 4-CH.sub.3  CO.sub.2 CH.sub.2 CH.sub.3                            O H  F  H  1 4-CH.sub.3  CO.sub.2 CH.sub.2 CH.sub.3                            S F  F  H  1 4-CH.sub.3  CO.sub.2 CH.sub.2 CH.sub.3                            O F  F  H  1 4-CH.sub.3  CO.sub.2 CH.sub.2 CH.sub.3                            S H  Cl H  1 4-CH.sub.3  CO.sub.2 CH.sub.2 CH.sub.3                            O H  Cl H  1 4-CH.sub.3  CO.sub.2 CH.sub.2 CH.sub.3                            S F  Cl H  1 4-CH.sub.3  CO.sub.2 CH.sub.2 CH.sub.3                            O F  Cl H  1 4-CH.sub.3  CO.sub.2 CH.sub. 2 CH.sub.3                           S H  F  CH.sub.3                                                                          1 4-CH.sub.3  CO.sub.2 CH.sub.2 CH.sub.3                            O H  F  CH.sub.3                                                                          1 4-CH.sub.3  CO.sub.2 CH.sub.2 CH.sub.3                            S F  F  CH.sub.3                                                                          1 4-CH.sub.3  CO.sub.2 CH.sub.2 CH.sub.3                            O F  F  CH.sub.3                                                                          1 4-CH.sub.3  CO.sub.2 CH.sub.2 CH.sub.3                            S H  Cl CH.sub.3                                                                          1 4-CH.sub.3  CO.sub.2 CH.sub.2 CH.sub.3                            O H  Cl CH.sub.3                                                                          1 4-CH.sub.3  CO.sub.2 CH.sub.2 CH.sub.3                            S F  Cl CH.sub.3                                                                          1 4-CH.sub.3  CO.sub.2 CH.sub.2 CH.sub.3                            O F  Cl CH.sub.3                                                                          1 4-CH.sub.3  CO.sub.2 CH.sub.2 CH.sub.3                            S H  F  H  1 4-CH.sub.3  CO.sub.2 (CH.sub.2).sub.2 CH.sub.3                    O H  F  H  1 4-CH.sub.3  CO.sub.2 (CH.sub.2).sub.2 CH.sub.3                    S F  F  H  1 4-CH.sub.3  CO.sub.2 (CH.sub.2).sub.2 CH.sub.3                    O F  F  H  1 4-CH.sub.3  CO.sub.2 (CH.sub.2).sub.2 CH.sub.3                    S H  Cl H  1 4-CH.sub.3  CO.sub.2 (CH.sub.2).sub.2 CH.sub.3                    O H  Cl H  1 4-CH.sub.3  CO.sub.2 (CH.sub. 2).sub.2 CH.sub.3                   S F  Cl H  1 4-CH.sub.3  CO.sub.2 (CH.sub.2).sub.2 CH.sub.3                    O F  Cl H  1 4-CH.sub.3  CO.sub.2 (CH.sub.2).sub.2 CH.sub.3                    S H  F  CH.sub.3                                                                          1 4-CH.sub.3  CO.sub.2 (CH.sub.2).sub.2 CH.sub.3                    O H  F  CH.sub.3                                                                          1 4-CH.sub.3  CO.sub.2 (CH.sub.2).sub.2 CH.sub.3                    S F  F  CH.sub.3                                                                          1 4-CH.sub.3  CO.sub.2 (CH.sub.2).sub.2 CH.sub.3                    O F  F  CH.sub.3                                                                          1 4-CH.sub.3  CO.sub.2 (CH.sub.2).sub.2 CH.sub.3                    S H  Cl CH.sub.3                                                                          1 4-CH.sub.3  CO.sub.2 (CH.sub.2).sub.2 CH.sub.3                    O H  Cl CH.sub.3                                                                          1 4-CH.sub.3  CO.sub.2 (CH.sub.2).sub.2 CH.sub.3                    S F  Cl CH.sub.3                                                                          1 4-CH.sub.3  CO.sub.2 (CH.sub.2).sub.2 CH.sub.3                    O F  Cl CH.sub.3                                                                          1 4-CH.sub.3  CO.sub.2 (CH.sub.2).sub.2 CH.sub.3                    S H  F  H  1 4-CH.sub.3  CO.sub.2 CH(CH.sub.3).sub.2                           O H  F  H  1 4-CH.sub.3  CO.sub.2 CH(CH.sub.3).sub.2                           S F  F  H  1 4-CH.sub.3  CO.sub.2 CH(CH.sub. 3).sub.2                          O F  F  H  1 4-CH.sub.3  CO.sub.2 CH(CH.sub.3).sub.2                           S H  Cl H  1 4-CH.sub.3  CO.sub.2 CH(CH.sub.3).sub.2                           O H  Cl H  1 4-CH.sub.3  CO.sub.2 CH(CH.sub.3).sub.2                           S F  Cl H  1 4-CH.sub.3  CO.sub.2 CH(CH.sub.3).sub.2                           O F  Cl H  1 4-CH.sub.3  CO.sub.2 CH(CH.sub.3).sub.2                           S H  F  CH.sub.3                                                                          1 4-CH.sub.3  CO.sub.2 CH(CH.sub.3).sub.2                           O H  F  CH.sub.3                                                                          1 4-CH.sub.3  CO.sub.2 CH(CH.sub.3).sub.2                           S F  F  CH.sub.3                                                                          1 4-CH.sub.3  CO.sub.2 CH(CH.sub.3).sub.2                           O F  F  CH.sub.3                                                                          1 4-CH.sub.3  CO.sub.2 CH(CH.sub.3).sub.2                           S H  Cl CH.sub.3                                                                          1 4-CH.sub.3  CO.sub.2 CH(CH.sub.3).sub.2                           O H  Cl CH.sub.3                                                                          1 4-CH.sub.3  CO.sub.2 CH(CH.sub.3).sub.2                           S F  Cl CH.sub.3                                                                          1 4-CH.sub.3  CO.sub.2 CH(CH.sub.3).sub.2                           O F  Cl CH.sub.3                                                                          1 4-CH.sub.3  CO.sub.2 CH(CH.sub.3).sub.2                           S H  F  H  1 4-CH.sub.3  CO.sub.2 (CH.sub.2).sub.3 CH.sub.3                    O H  F  H  1 4-CH.sub.3  CO.sub.2 (CH.sub.2).sub.3 CH.sub.3                    S F  F  H  1 4-CH.sub.3  CO.sub.2 (CH.sub.2).sub.3 CH.sub.3                    O F  F  H  1 4-CH.sub.3  CO.sub.2 (CH.sub.2).sub.3 CH.sub.3                    S H  Cl H  1 4-CH.sub.3  CO.sub.2 (CH.sub.2).sub.3 CH.sub.3                    O H  Cl H  1 4-CH.sub.3  CO.sub.2 (CH.sub.2).sub.3 CH.sub.3                    S F  Cl H  1 4-CH.sub.3  CO.sub.2 (CH.sub.2).sub.3 CH.sub.3                    O F  Cl H  1 4-CH.sub.3  CO.sub.2 (CH.sub.2).sub.3 CH.sub.3                    S H  F  CH.sub.3                                                                          1 4-CH.sub.3  CO.sub.2 (CH.sub.2).sub.3 CH.sub.3                    O H  F  CH.sub.3                                                                          1 4-CH.sub.3  CO.sub.2 (CH.sub.2).sub.3 CH.sub.3                    S F  F  CH.sub.3                                                                          1 4-CH.sub.3  CO.sub.2 (CH.sub.2).sub.3 CH.sub.3                    O F  F  CH.sub.3                                                                          1 4-CH.sub.3  CO.sub.2 (CH.sub.2).sub.3 CH.sub.3                    S H  Cl CH.sub.3                                                                          1 4-CH.sub.3  CO.sub.2 (CH.sub.2).sub.3 CH.sub.3                    O H  Cl CH.sub.3                                                                          1 4-CH.sub.3  CO.sub.2 (CH.sub.2).sub.3 CH.sub.3                    S F  Cl CH.sub. 3                                                                         1 4-CH.sub.3  CO.sub.2 (CH.sub.2).sub.3 CH.sub.3                    O F  Cl CH.sub.3                                                                          1 4-CH.sub.3  CO.sub.2 (CH.sub.2).sub.3 CH.sub.3                    S H  F  H  1 4-CH.sub.3  CO.sub.2 (CH.sub.2).sub.2 OCH.sub.3                   O H  F  H  1 4-CH.sub.3  CO.sub.2 (CH.sub.2).sub.2 OCH.sub.3                   S F  F  H  1 4-CH.sub.3  CO.sub.2 (CH.sub.2).sub.2 OCH.sub.3                   O F  F  H  1 4-CH.sub.3  CO.sub.2 (CH.sub.2).sub.2 OCH.sub.3                   S H  Cl H  1 4-CH.sub.3  CO.sub.2 (CH.sub.2).sub.2 OCH.sub.3                   O H  Cl H  1 4-CH.sub.3  CO.sub.2 (CH.sub.2).sub.2 OCH.sub.3                   S F  Cl H  1 4-CH.sub.3  CO.sub.2 (CH.sub.2).sub.2 OCH.sub.3                   O F  Cl H  1 4-CH.sub.3  CO.sub.2 (CH.sub.2).sub.2 OCH.sub.3                   S H  F  CH.sub.3                                                                          1 4-CH.sub.3  CO.sub.2 (CH.sub.2).sub.2 OCH.sub.3                   O H  F  CH.sub.3                                                                          1 4-CH.sub.3  CO.sub.2 (CH.sub.2).sub.2 OCH.sub.3                   S F  F  CH.sub.3                                                                          1 4-CH.sub.3  CO.sub.2 (CH.sub.2).sub.2 OCH.sub.3                   O F  F  CH.sub.3                                                                          1 4-CH.sub.3  CO.sub.2 (CH.sub.2).sub.2 OCH.sub.3                   S H  Cl CH.sub.3                                                                          1 4-CH.sub.3  CO.sub.2 (CH.sub.2).sub.2 OCH.sub.3                   O H  Cl CH.sub.3                                                                          1 4-CH.sub.3  CO.sub.2 (CH.sub.2).sub.2 OCH.sub.3                   S F  Cl CH.sub.3                                                                          1 4-CH.sub.3  CO.sub.2 (CH.sub.2).sub.2 OCH.sub.3                   O F  Cl CH.sub.3                                                                          1 4-CH.sub.3  CO.sub.2 (CH.sub.2).sub.2 OCH.sub.3                   S H  F  H  1 4-CH.sub.3  CO.sub.2 (CH.sub.2).sub.2 OCH.sub.2 CH.sub.3          O H  F  H  1 4-CH.sub.3  CO.sub.2 (CH.sub.2).sub.2 OCH.sub.2 CH.sub.3          S F  F  H  1 4-CH.sub.3  CO.sub.2 (CH.sub.2).sub.2 OCH.sub.2 CH.sub.3          O F  F  H  1 4-CH.sub.3  CO.sub.2 (CH.sub.2).sub.2 OCH.sub.2 CH.sub.3          S H  Cl H  1 4-CH.sub.3  CO.sub.2 (CH.sub.2).sub.2 OCH.sub.2 CH.sub.3          O H  Cl H  1 4-CH.sub.3  CO.sub.2 (CH.sub.2).sub.2 OCH.sub.2 CH.sub.3          S F  Cl H  1 4-CH.sub.3  CO.sub.2 (CH.sub.2).sub.2 OCH.sub.2 CH.sub.3          O F  Cl H  1 4-CH.sub.3  CO.sub.2 (CH.sub.2).sub.2 OCH.sub.2 CH.sub.3          S H  F  CH.sub.3                                                                          1 4-CH.sub.3  CO.sub.2 (CH.sub.2).sub.2 OCH.sub.2 CH.sub.3          O H  F  CH.sub.3                                                                          1 4-CH.sub.3  CO.sub.2 (CH.sub.2).sub.2 OCH.sub.2 CH.sub.3          S F  F  CH.sub.3                                                                          1 4-CH.sub.3  CO.sub.2 (CH.sub.2).sub.2 OCH.sub.2 CH.sub.3          O F  F  CH.sub.3                                                                          1 4-CH.sub.3  CO.sub.2 (CH.sub.2).sub.2 OCH.sub.2 CH.sub.3          S H  Cl CH.sub.3                                                                          1 4-CH.sub.3  CO.sub.2 (CH.sub.2).sub.2 OCH.sub.2 CH.sub.3          O H  Cl CH.sub.3                                                                          1 4-CH.sub.3  CO.sub.2 (CH.sub.2).sub.2 OCH.sub.2 CH.sub.3          S F  Cl CH.sub.3                                                                          1 4-CH.sub.3  CO.sub.2 (CH.sub.2).sub.2 OCH.sub.2 CH.sub.3          O F  Cl CH.sub.3                                                                          1 4-CH.sub.3  CO.sub.2 (CH.sub.2).sub.2 OCH.sub.2 CH.sub.3          S H  F  H  1 6-CH.sub.3  CO.sub.2 CH.sub.3                                     O H  F  H  1 6-CH.sub.3  CO.sub.2 CH.sub.3                                     S F  F  H  1 6-CH.sub.3  CO.sub.2 CH.sub.3                                     O F  F  H  1 6-CH.sub.3  CO.sub.2 CH.sub.3                                     S H  Cl H  1 6-CH.sub.3  CO.sub.2 CH.sub.3                                     O H  Cl H  1 6-CH.sub.3  CO.sub.2 CH.sub.3                                     S F  Cl H  1 6-CH.sub.3  CO.sub.2 CH.sub.3                                     O F  Cl H  1 6-CH.sub.3  CO.sub.2 CH.sub.3                                     S H  F  CH.sub.3                                                                          1 6-CH.sub.3  CO.sub.2 CH.sub.3                                     O H  F  CH.sub.3                                                                          1 6-CH.sub.3  CO.sub.2 CH.sub.3                                     S F  F  CH.sub.3                                                                          1 6-CH.sub.3  CO.sub.2 CH.sub.3                                     O F  F  CH.sub.3                                                                          1 6-CH.sub.3  CO.sub.2 CH.sub.3                                     S H  Cl CH.sub.3                                                                          1 6-CH.sub.3  CO.sub.2 CH.sub.3                                     O H  Cl CH.sub.3                                                                          1 6-CH.sub.3  CO.sub.2 CH.sub.3                                     S F  Cl CH.sub.3                                                                          1 6-CH.sub.3  CO.sub.2 CH.sub.3                                     O F  Cl CH.sub.3                                                                          1 6-CH.sub.3  CO.sub.2 CH.sub.3                                     S H  F  H  1 6-CH.sub.3  CO.sub.2 CH.sub.2 CH.sub.3                            O H  F  H  1 6-CH.sub.3  CO.sub.2 CH.sub.2 CH.sub.3                            S F  F  H  1 6-CH.sub.3  CO.sub.2 CH.sub.2 CH.sub.3                            O F  F  H  1 6-CH.sub.3  CO.sub.2 CH.sub.2 CH.sub.3                            S H  Cl H  1 6-CH.sub. 3 CO.sub.2 CH.sub.2 CH.sub.3                            O H  Cl H  1 6-CH.sub.3  CO.sub.2 CH.sub.2 CH.sub.3                            S F  Cl H  1 6-CH.sub.3  CO.sub.2 CH.sub.2 CH.sub.3                            O F  Cl H  1 6-CH.sub.3  CO.sub.2 CH.sub.2 CH.sub.3                            S H  F  CH.sub.3                                                                          1 6-CH.sub.3  CO.sub.2 CH.sub.2 CH.sub.3                            O H  F  CH.sub.3                                                                          1 6-CH.sub.3  CO.sub.2 CH.sub.2 CH.sub.3                            S F  F  CH.sub.3                                                                          1 6-CH.sub.3  CO.sub.2 CH.sub.2 CH.sub.3                            O F  F  CH.sub.3                                                                          1 6-CH.sub.3  CO.sub.2 CH.sub.2 CH.sub.3                            S H  Cl CH.sub.3                                                                          1 6-CH.sub.3  CO.sub.2 CH.sub.2 CH.sub.3                            O H  Cl CH.sub.3                                                                          1 6-CH.sub.3  CO.sub.2 CH.sub.2 CH.sub.3                            S F  Cl CH.sub.3                                                                          1 6-CH.sub.3  CO.sub.2 CH.sub.2 CH.sub.3                            O F  Cl CH.sub.3                                                                          1 6-CH.sub.3  CO.sub.2 CH.sub.2 CH.sub.3                            S H  F  H  1 6-CH.sub.3  CO.sub.2 (CH.sub.2).sub.2 CH.sub.3                    O H  F  H  1 6-CH.sub.3  CO.sub.2 (CH.sub.2).sub.2 CH.sub.3                    S F  F  H  1 6-CH.sub.3  CO.sub.2 (CH.sub.2 ).sub.2 CH.sub.3                   O F  F  H  1 6-CH.sub.3  CO.sub.2 (CH.sub.2).sub.2 CH.sub.3                    S H  Cl H  1 6-CH.sub.3  CO.sub.2 (CH.sub.2).sub.2 CH.sub.3                    O H  Cl H  1 6-CH.sub.3  CO.sub.2 (CH.sub.2).sub.2 CH.sub.3                    S F  Cl H  1 6-CH.sub.3  CO.sub.2 (CH.sub.2).sub.2 CH.sub.3                    O F  Cl H  1 6-CH.sub.3  CO.sub.2 (CH.sub.2).sub.2 CH.sub.3                    S H  F  CH.sub.3                                                                          1 6-CH.sub.3  CO.sub.2 (CH.sub.2).sub.2 CH.sub.3                    O H  F  CH.sub.3                                                                          1 6-CH.sub.3  CO.sub.2 (CH.sub.2).sub.2 CH.sub.3                    S F  F  CH.sub.3                                                                          1 6-CH.sub.3  CO.sub.2 (CH.sub.2).sub.2 CH.sub.3                    O F  F  CH.sub.3                                                                          1 6-CH.sub.3  CO.sub.2 (CH.sub.2).sub.2 CH.sub.3                    S H  Cl CH.sub.3                                                                          1 6-CH.sub.3  CO.sub.2 (CH.sub.2).sub.2 CH.sub.3                    O H  Cl CH.sub.3                                                                          1 6-CH.sub.3  CO.sub.2 (CH.sub.2).sub.2 CH.sub.3                    S F  Cl CH.sub.3                                                                          1 6-CH.sub.3  CO.sub.2 (CH.sub.2).sub.2 CH.sub.3                    O F  Cl CH.sub.3                                                                          1 6-CH.sub.3  CO.sub. 2 (CH.sub.2).sub.2 CH.sub.3                   S H  F  H  1 6-CH.sub.3  CO.sub.2 CH(CH.sub.3).sub.2                           O H  F  H  1 6-CH.sub.3  CO.sub.2 CH(CH.sub.3).sub.2                           S F  F  H  1 6-CH.sub.3  CO.sub.2 CH(CH.sub.3).sub.2                           O F  F  H  1 6-CH.sub.3  CO.sub.2 CH(CH.sub.3).sub.2                           S H  Cl H  1 6-CH.sub.3  CO.sub.2 CH(CH.sub.3).sub.2                           O H  Cl H  1 6-CH.sub.3  CO.sub.2 CH(CH.sub.3).sub.2                           S F  Cl H  1 6-CH.sub.3  CO.sub.2 CH(CH.sub.3).sub.2                           O F  Cl H  1 6-CH.sub.3  CO.sub.2 CH(CH.sub.3).sub.2                           S H  F  CH.sub.3                                                                          1 6-CH.sub.3  CO.sub.2 CH(CH.sub.3).sub.2                           O H  F  CH.sub.3                                                                          1 6-CH.sub.3  CO.sub.2 CH(CH.sub.3).sub.2                           S F  F  CH.sub.3                                                                          1 6-CH.sub.3  CO.sub.2 CH(CH.sub.3).sub.2                           O F  F  CH.sub.3                                                                          1 6-CH.sub.3  CO.sub.2 CH(CH.sub.3).sub.2                           S H  Cl CH.sub.3                                                                          1 6-CH.sub.3  CO.sub.2 CH(CH.sub.3).sub.2                           O H  Cl CH.sub.3                                                                          1 6-CH.sub.3  CO.sub.2 CH(CH.sub.3).sub.2                           S F  Cl CH.sub.3                                                                          1 6-CH.sub.3  CO.sub.2 CH(CH.sub.3).sub.2                           O F  Cl CH.sub.3                                                                          1 6-CH.sub.3  CO.sub.2 CH(CH.sub.3).sub.2                           S H  F  H  1 6-CH.sub.3  CO.sub.2 (CH.sub.2).sub.3 CH.sub.3                    O H  F  H  1 6-CH.sub.3  CO.sub.2 (CH.sub.2).sub.3 CH.sub.3                    S F  F  H  1 6-CH.sub.3  CO.sub.2 (CH.sub.2).sub.3 CH.sub.3                    O F  F  H  1 6-CH.sub.3  CO.sub.2 (CH.sub.2).sub.3 CH.sub.3                    S H  Cl H  1 6-CH.sub.3  CO.sub.2 (CH.sub.2).sub.3 CH.sub.3                    O H  Cl H  1 6-CH.sub.3  CO.sub.2 (CH.sub.2).sub.3 CH.sub.3                    S F  Cl H  1 6-CH.sub.3  CO.sub.2 (CH.sub.2).sub.3 CH.sub.3                    O F  Cl H  1 6-CH.sub.3  CO.sub.2 (CH.sub.2).sub.3 CH.sub.3                    S H  F  CH.sub.3                                                                          1 6-CH.sub.3  CO.sub.2 (CH.sub.2).sub.3 CH.sub.3                    O H  F  CH.sub.3                                                                          1 6-CH.sub.3  CO.sub.2 (CH.sub.2).sub.3 CH.sub.3                    S F  F  CH.sub.3                                                                          1 6-CH.sub.3  CO.sub.2 (CH.sub.2).sub.3 CH.sub.3                    O F  F  CH.sub.3                                                                          1 6-CH.sub.3  CO.sub.2 (CH.sub.2).sub.3 CH.sub.3                    S H  Cl CH.sub.3                                                                          1 6-CH.sub.3  CO.sub.2 (CH.sub.2).sub.3 CH.sub.3                    O H  Cl CH.sub.3                                                                          1 6-CH.sub.3  CO.sub.2 (CH.sub.2).sub.3 CH.sub.3                    S F  Cl CH.sub.3                                                                          1 6-CH.sub.3  CO.sub.2 (CH.sub.2).sub.3 CH.sub.3                    O F  Cl CH.sub.3                                                                          1 6-CH.sub.3  CO.sub.2 (CH.sub.2).sub.3 CH.sub.3                    S H  F  H  1 6-CH.sub.3  CO.sub.2 (CH.sub.2).sub.2 OCH.sub.3                   O H  F  H  1 6-CH.sub.3  CO.sub.2 (CH.sub.2).sub.2 OCH.sub.3                   S F  F  H  1 6-CH.sub.3  CO.sub.2 (CH.sub.2).sub.2 OCH.sub.3                   O F  F  H  1 6-CH.sub.3  CO.sub.2 (CH.sub.2).sub.2 OCH.sub.3                   S H  Cl H  1 6-CH.sub.3  CO.sub.2 (CH.sub.2).sub.2 OCH.sub.3                   O H  Cl H  1 6-CH.sub.3  CO.sub.2 (CH.sub.2).sub.2 OCH.sub.3                   S F  Cl H  1 6-CH.sub.3  CO.sub.2 (CH.sub.2).sub.2 OCH.sub.3                   O F  Cl H  1 6-CH.sub.3  CO.sub.2 (CH.sub.2).sub.2 OCH.sub.3                   S H  F  CH.sub.3                                                                          1 6-CH.sub.3  CO.sub.2 (CH.sub.2).sub.2 OCH.sub.3                   O H  F  CH.sub.3                                                                          1 6-CH.sub.3  CO.sub.2 (CH.sub.2).sub.2 OCH.sub.3                   S F  F  CH.sub.3                                                                          1 6-CH.sub.3  CO.sub.2 (CH.sub.2).sub.2 OCH.sub.3                   O F  F  CH.sub.3                                                                          1 6-CH.sub.3  CO.sub.2 (CH.sub.2).sub.2 OCH.sub.3                   S H  Cl CH.sub.3                                                                          1 6-CH.sub.3  CO.sub.2 (CH.sub.2).sub.2 OCH.sub.3                   O H  Cl CH.sub.3                                                                          1 6-CH.sub.3  CO.sub.2 (CH.sub.2).sub.2 OCH.sub.3                   S F  Cl CH.sub.3                                                                          1 6-CH.sub.3  CO.sub.2 (CH.sub.2).sub.2 OCH.sub.3                   O F  Cl CH.sub.3                                                                          1 6-CH.sub.3  CO.sub.2 (CH.sub.2).sub.2 OCH.sub.3                   S H  F  H  1 6-CH.sub.3  CO.sub.2 (CH.sub.2).sub.2 OCH.sub.2 CH.sub.3          O H  F  H  1 6-CH.sub.3  CO.sub.2 (CH.sub.2).sub.2 OCH.sub.2 CH.sub.3          S F  F  H  1 6-CH.sub.3  CO.sub.2 (CH.sub.2).sub.2 OCH.sub.2 CH.sub.3          O F  F  H  1 6-CH.sub.3  CO.sub.2 (CH.sub.2).sub.2 OCH.sub.2 CH.sub.3          S H  Cl H  1 6-CH.sub.3  CO.sub.2 (CH.sub.2 ).sub.2 OCH.sub.2 CH.sub.3         O H  Cl H  1 6-CH.sub.3  CO.sub.2 (CH.sub.2).sub.2 OCH.sub.2 CH.sub.3          S F  Cl H  1 6-CH.sub.3  CO.sub.2 (CH.sub.2).sub.2 OCH.sub.2 CH.sub.3          O F  Cl H  1 6-CH.sub.3  CO.sub.2 (CH.sub.2).sub.2 OCH.sub.2 CH.sub.3          S H  F  CH.sub.3                                                                          1 6-CH.sub.3  CO.sub.2 (CH.sub.2).sub.2 OCH.sub.2 CH.sub.3          O H  F  CH.sub.3                                                                          1 6-CH.sub.3  CO.sub.2 (CH.sub.2).sub.2 OCH.sub.2 CH.sub.3          S F  F  CH.sub.3                                                                          1 6-CH.sub.3  CO.sub.2 (CH.sub.2).sub.2 OCH.sub.2 CH.sub.3          O F  F  CH.sub.3                                                                          1 6-CH.sub.3  CO.sub.2 (CH.sub.2).sub.2 OCH.sub.2 CH.sub.3          S H  Cl CH.sub.3                                                                          1 6-CH.sub.3  CO.sub.2 (CH.sub.2).sub.2 OCH.sub.2 CH.sub.3          O H  Cl CH.sub.3                                                                          1 6-CH.sub.3  CO.sub.2 (CH.sub.2).sub.2 OCH.sub.2 CH.sub.3          S F  Cl CH.sub.3                                                                          1 6-CH.sub.3  CO.sub.2 (CH.sub.2).sub.2 OCH.sub.2 CH.sub.3          O F  Cl CH.sub.3                                                                          1 6-CH.sub.3  CO.sub.2 (CH.sub.2).sub.2 OCH.sub.2 CH.sub. 3         S H  F  H  1 4,6-Di-CH.sub.3                                                                            CO.sub.2 CH.sub.3                                     O H  F  H  1 4,6-Di-CH.sub.3                                                                            CO.sub.2 CH.sub.3                                     S F  F  H  1 4,6-Di-CH.sub.3                                                                            CO.sub.2 CH.sub.3                                     O F  F  H  1 4,6-Di-CH.sub.3                                                                            CO.sub.2 CH.sub.3                                     S H  Cl H  1 4,6-Di-CH.sub.3                                                                            CO.sub.2 CH.sub.3                                     O H  Cl H  1 4,6-Di-CH.sub.3                                                                            CO.sub.2 CH.sub.3                                     S F  Cl H  1 4,6-Di-CH.sub.3                                                                            CO.sub.2 CH.sub.3                                     O F  Cl H  1 4,6-Di-CH.sub.3                                                                            CO.sub.2 CH.sub.3                                     S H  F  CH.sub.3                                                                          1 4,6-Di-CH.sub.3                                                                            CO.sub.2 CH.sub.3                                     O H  F  CH.sub.3                                                                          1 4,6-Di-CH.sub.3                                                                            CO.sub.2 CH.sub.3                                     S F  F  CH.sub.3                                                                          1 4,6-Di-CH.sub.3                                                                            CO.sub.2 CH.sub.3                                     O F  F  CH.sub.3                                                                          1 4,6-Di-CH.sub.3                                                                            CO.sub.2 CH.sub.3                                     S H  Cl CH.sub.3                                                                          1 4,6-Di-CH.sub.3                                                                            CO.sub.2 CH.sub.3                                     O H  Cl CH.sub.3                                                                          1 4,6-Di-CH.sub.3                                                                            CO.sub.2 CH.sub.3                                     S F  Cl CH.sub.3                                                                          1 4,6-Di-CH.sub.3                                                                            CO.sub.2 CH.sub.3                                     O F  Cl CH.sub.3                                                                          1 4,6-Di-CH.sub.3                                                                            CO.sub.2 CH.sub.3                                     S H  F  H  1 4,6-Di-CH.sub.3                                                                            CO.sub.2 CH.sub.2 CH.sub.3                            O H  F  H  1 4,6-Di-CH.sub.3                                                                            CO.sub.2 CH.sub.2 CH.sub.3                            S F  F  H  1 4,6-Di-CH.sub.3                                                                            CO.sub.2 CH.sub.2 CH.sub.3                            O F  F  H  1 4,6-Di-CH.sub.3                                                                            CO.sub.2 CH.sub.2 CH.sub.3                            S H  Cl H  1 4,6-Di-CH.sub.3                                                                            CO.sub.2 CH.sub.2 CH.sub.3                            O H  Cl H  1 4,6-Di-CH.sub.3                                                                            CO.sub.2 CH.sub.2 CH.sub.3                            S F  Cl H  1 4,6-Di-CH.sub.3                                                                            CO.sub.2 CH.sub.2 CH.sub.3                            O F  Cl H  1 4,6-Di-CH.sub.3                                                                            CO.sub.2 CH.sub.2 CH.sub.3                            S H  F  CH.sub.3                                                                          1 4,6-Di-CH.sub.3                                                                            CO.sub.2 CH.sub.2 CH.sub.3                            O H  F  CH.sub.3                                                                          1 4,6-Di-CH.sub.3                                                                            CO.sub.2 CH.sub.2 CH.sub.3                            S F  F  CH.sub.3                                                                          1 4,6-Di-CH.sub.3                                                                            CO.sub.2 CH.sub.2 CH.sub.3                            O F  F  CH.sub.3                                                                          1 4,6-Di-CH.sub.3                                                                            CO.sub.2 CH.sub.2 CH.sub.3                            S H  Cl CH.sub.3                                                                          1 4,6-Di-CH.sub.3                                                                            CO.sub.2 CH.sub.2 CH.sub.3                            O H  Cl CH.sub.3                                                                          1 4,6-Di-CH.sub.3                                                                            CO.sub.2 CH.sub.2 CH.sub.3                            S F  Cl CH.sub.3                                                                          1 4,6-Di-CH.sub.3                                                                            CO.sub.2 CH.sub.2 CH.sub.3                            O F  Cl CH.sub.3                                                                          1 4,6-Di-CH.sub.3                                                                            CO.sub.2 CH.sub.2 CH.sub.3                            S H  F  H  1 4,6-Di-CH.sub.3                                                                            CO.sub.2 (CH.sub.2).sub.2 CH.sub.3                    O H  F  H  1 4,6-Di-CH.sub.3                                                                            CO.sub.2 (CH.sub.2).sub.2 CH.sub.3                    S F  F  H  1 4,6-Di-CH.sub.3                                                                            CO.sub.2 (CH.sub.2).sub.2 CH.sub.3                    O F  F  H  1 4,6-Di-CH.sub.3                                                                            CO.sub.2 (CH.sub.2).sub.2 CH.sub.3                    S H  Cl H  1 4,6-Di-CH.sub.3                                                                            CO.sub.2 (CH.sub.2).sub.2 CH.sub.3                    O H  Cl H  1 4,6-Di-CH.sub.3                                                                            CO.sub.2 (CH.sub.2).sub.2 CH.sub.3                    S F  Cl H  1 4,6-Di-CH.sub.3                                                                            CO.sub.2 (CH.sub.2).sub.2 CH.sub.3                    O F  Cl H  1 4,6-Di-CH.sub.3                                                                            CO.sub.2 (CH.sub.2).sub.2 CH.sub.3                    S H  F  CH.sub.3                                                                          1 4,6-Di-CH.sub.3                                                                            CO.sub.2 (CH.sub.2).sub.2 CH.sub.3                    O H  F  CH.sub.3                                                                          1 4,6-Di-CH.sub.3                                                                            CO.sub.2 (CH.sub.2).sub.2 CH.sub.3                    S F  F  CH.sub.3                                                                          1 4,6-Di-CH.sub.3                                                                            CO.sub.2 (CH.sub.2).sub.2 CH.sub.3                    O F  F  CH.sub.3                                                                          1 4,6-Di-CH.sub.3                                                                            CO.sub.2 (CH.sub.2).sub.2 CH.sub.3                    S H  Cl CH.sub.3                                                                          1 4,6-Di-CH.sub.3                                                                            CO.sub.2 (CH.sub.2).sub.2 CH.sub.3                    O H  Cl CH.sub.3                                                                          1 4,6-Di-CH.sub.3                                                                            CO.sub.2 (CH.sub.2).sub.2 CH.sub.3                    S F  Cl CH.sub.3                                                                          1 4,6-Di-CH.sub.3                                                                            CO.sub.2 (CH.sub.2).sub.2 CH.sub.3                    O F  Cl CH.sub.3                                                                          1 4,6-Di-CH.sub.3                                                                            CO.sub.2 (CH.sub.2).sub.2 CH.sub.3                    S H  F  H  1 4,6-Di-CH.sub.3                                                                            CO.sub.2 CH(CH.sub.3).sub.2                           O H  F  H  1 4,6-Di-CH.sub.3                                                                            CO.sub.2 CH(CH.sub.3).sub.2                           S F  F  H  1 4,6-Di-CH.sub.3                                                                            CO.sub.2 CH(CH.sub.3).sub.2                           O F  F  H  1 4,6-Di-CH.sub.3                                                                            CO.sub.2 CH(CH.sub.3).sub.2                           S H  Cl H  1 4,6-Di-CH.sub.3                                                                            CO.sub.2 CH(CH.sub.3).sub.2                           O H  Cl H  1 4,6-Di-CH.sub.3                                                                            CO.sub.2 CH(CH.sub.3).sub.2                           S F  Cl H  1 4,6-Di-CH.sub.3                                                                            CO.sub.2 CH(CH.sub.3).sub.2                           O F  Cl H  1 4,6-Di-CH.sub.3                                                                            CO.sub.2 CH(CH.sub.3).sub.2                           S H  F  CH.sub.3                                                                          1 4,6-Di-CH.sub.3                                                                            CO.sub.2 CH(CH.sub.3).sub.2                           O H  F  CH.sub.3                                                                          1 4,6-Di-CH.sub.3                                                                            CO.sub.2 CH(CH.sub.3).sub.2                           S F  F  CH.sub.3                                                                          1 4,6-Di-CH.sub.3                                                                            CO.sub.2 CH(CH.sub.3).sub.2                           O F  F  CH.sub. 3                                                                         1 4,6-Di-CH.sub.3                                                                            CO.sub.2 CH(CH.sub.3).sub.2                           S H  Cl CH.sub.3                                                                          1 4,6-Di-CH.sub.3                                                                            CO.sub.2 CH(CH.sub.3).sub.2                           O H  Cl CH.sub.3                                                                          1 4,6-Di-CH.sub.3                                                                            CO.sub.2 CH(CH.sub.3).sub.2                           S F  Cl CH.sub.3                                                                          1 4,6-Di-CH.sub.3                                                                            CO.sub.2 CH(CH.sub.3).sub.2                           O F  Cl CH.sub.3                                                                          1 4,6-Di-CH.sub.3                                                                            CO.sub.2 CH(CH.sub.3).sub.2                           S H  F  H  1 4,6-Di-CH.sub.3                                                                            CO.sub.2 (CH.sub.2).sub.3 CH.sub.3                    O H  F  H  1 4,6-Di-CH.sub.3                                                                            CO.sub.2 (CH.sub.2).sub.3 CH.sub.3                    S F  F  H  1 4,6-Di-CH.sub.3                                                                            CO.sub.2 (CH.sub.2).sub.3 CH.sub.3                    O F  F  H  1 4,6-Di-CH.sub.3                                                                            CO.sub.2 (CH.sub.2).sub.3 CH.sub.3                    S H  Cl H  1 4,6-Di-CH.sub.3                                                                            CO.sub.2 (CH.sub.2).sub.3 CH.sub.3                    O H  Cl H  1 4,6-Di-CH.sub.3                                                                            CO.sub.2 (CH.sub.2).sub.3 CH.sub.3                    S F  Cl H  1 4,6-Di-CH.sub.3                                                                            CO.sub.2 (CH.sub.2).sub.3 CH.sub.3                    O F  Cl H  1 4,6-Di-CH.sub.3                                                                            CO.sub.2 (CH.sub.2).sub.3 CH.sub.3                    S H  F  CH.sub.3                                                                          1 4,6-Di-CH.sub.3                                                                            CO.sub.2 (CH.sub.2).sub.3 CH.sub.3                    O H  F  CH.sub.3                                                                          1 4,6-Di-CH.sub.3                                                                            CO.sub.2 (CH.sub.2).sub.3 CH.sub.3                    S F  F  CH.sub.3                                                                          1 4,6-Di-CH.sub.3                                                                            CO.sub.2 (CH.sub.2).sub.3 CH.sub.3                    O F  F  CH.sub.3                                                                          1 4,6-Di-CH.sub.3                                                                            CO.sub.2 (CH.sub.2).sub.3 CH.sub.3                    S H  Cl CH.sub.3                                                                          1 4,6-Di-CH.sub.3                                                                            CO.sub.2 (CH.sub.2).sub.3 CH.sub.3                    O H  Cl CH.sub.3                                                                          1 4,6-Di-CH.sub.3                                                                            CO.sub.2 (CH.sub.2).sub.3 CH.sub.3                    S F  Cl CH.sub.3                                                                          1 4,6-Di-CH.sub.3                                                                            CO.sub.2 (CH.sub.2).sub.3 CH.sub.3                    O F  Cl CH.sub.3                                                                          1 4,6-Di-CH.sub.3                                                                            CO.sub.2 (CH.sub.2).sub.3 CH.sub.3                    S H  F  H  1 4,6-Di-CH.sub.3                                                                            CO.sub.2 (CH.sub.2).sub.2 OCH.sub.3                   O H  F  H  1 4,6-Di-CH.sub.3                                                                            CO.sub.2 (CH.sub.2).sub.2 OCH.sub.3                   S F  F  H  1 4,6-Di-CH.sub.3                                                                            CO.sub.2 (CH.sub.2).sub.2 OCH.sub.3                   O F  F  H  1 4,6-Di-CH.sub.3                                                                            CO.sub.2 (CH.sub.2).sub.2 OCH.sub.3                   S H  Cl H  1 4,6-Di-CH.sub.3                                                                            CO.sub.2 (CH.sub.2).sub.2 OCH.sub.3                   O H  Cl H  1 4,6-Di-CH.sub.3                                                                            CO.sub.2 (CH.sub.2 ).sub.2 OCH.sub.3                  S F  Cl H  1 4,6-Di-CH.sub.3                                                                            CO.sub.2 (CH.sub.2).sub.2 OCH.sub.3                   O F  Cl H  1 4,6-Di-CH.sub.3                                                                            CO.sub.2 (CH.sub.2).sub.2 OCH.sub.3                   S H  F  CH.sub.3                                                                          1 4,6-Di-CH.sub.3                                                                            CO.sub.2 (CH.sub.2).sub.2 OCH.sub.3                   O H  F  CH.sub.3                                                                          1 4,6-Di-CH.sub.3                                                                            CO.sub.2 (CH.sub.2).sub.2 OCH.sub.3                   S F  F  CH.sub.3                                                                          1 4,6-Di-CH.sub.3                                                                            CO.sub.2 (CH.sub.2).sub.2 OCH.sub.3                   O F  F  CH.sub.3                                                                          1 4,6-Di-CH.sub.3                                                                            CO.sub.2 (CH.sub.2).sub.2 OCH.sub.3                   S H  Cl CH.sub.3                                                                          1 4,6-Di-CH.sub.3                                                                            CO.sub.2 (CH.sub.2).sub.2 OCH.sub.3                   O H  Cl CH.sub.3                                                                          1 4,6-Di-CH.sub.3                                                                            CO.sub.2 (CH.sub.2).sub.2 OCH.sub.3                   S F  Cl CH.sub.3                                                                          1 4,6-Di-CH.sub.3                                                                            CO.sub.2 (CH.sub.2).sub.2 OCH.sub.3                   O F  Cl CH.sub.3                                                                          1 4,6-Di-CH.sub.3                                                                            CO.sub.2 (CH.sub.2).sub.2 OCH.sub.3                   S H  F  H  1 4,6-Di-CH.sub.3                                                                            CO.sub.2 (CH.sub.2).sub.2 OCH.sub.2 CH.sub.3          O H  F  H  1 4,6-Di-CH.sub.3                                                                            CO.sub.2 (CH.sub.2).sub.2 OCH.sub.2 CH.sub.3          S F  F  H  1 4,6-Di-CH.sub.3                                                                            CO.sub.2 (CH.sub.2).sub.2 OCH.sub.2 CH.sub.3          O F  F  H  1 6-CH.sub.3  CO.sub.2 (CH.sub.2).sub.2 OCH.sub.2 CH.sub.3          S H  Cl H  1 6-CH.sub.3  CO.sub.2 (CH.sub.2).sub.2 OCH.sub.2 CH.sub.3          O H  Cl H  1 6-CH.sub.3  CO.sub.2 (CH.sub.2).sub.2 OCH.sub.2 CH.sub.3          S F  Cl H  1 6-CH.sub.3  CO.sub.2 (CH.sub.2).sub.2 OCH.sub.2 CH.sub.3          O F  Cl H  1 6-CH.sub.3  CO.sub.2 (CH.sub.2).sub.2 OCH.sub.2 CH.sub.3          S H  F  CH.sub.3                                                                          1 6-CH.sub.3  CO.sub.2 (CH.sub.2).sub.2 OCH.sub.2 CH.sub.3          O H  F  CH.sub.3                                                                          1 6-CH.sub.3  CO.sub.2 (CH.sub.2).sub.2 OCH.sub.2 CH.sub.3          S F  F  CH.sub.3                                                                          1 6-CH.sub.3  CO.sub.2 (CH.sub.2).sub.2 OCH.sub.2 CH.sub.3          O F  F  CH.sub.3                                                                          1 6-CH.sub.3  CO.sub.2 (CH.sub.2).sub.2 OCH.sub.2 CH.sub.3          S H  Cl CH.sub.3                                                                          1 6-CH.sub.3  CO.sub.2 (CH.sub.2).sub.2 OCH.sub.2 CH.sub.3          O H  Cl CH.sub.3                                                                          1 6-CH.sub.3  CO.sub.2 (CH.sub.2 ).sub.2 OCH.sub.2 CH.sub.3         S F  Cl CH.sub.3                                                                          1 6-CH.sub.3  CO.sub.2 (CH.sub.2).sub.2 OCH.sub.2 CH.sub.3          O F  Cl CH.sub.3                                                                          1 6-CH.sub.3  CO.sub.2 (CH.sub.2).sub.2 OCH.sub.2 CH.sub.3          S H  F  H  0 H           H                                                     O H  F  H  0 H           H                                                     S F  F  H  0 H           H                                                     O F  F  H  0 H           H                                                     S H  Cl H  0 H           H                                                     O H  Cl H  0 H           H                                                     S F  Cl H  0 H           H                                                     O F  Cl H  0 H           H                                                     S H  F  CH.sub.3                                                                          0 H           H                                                     O H  F  CH.sub.3                                                                          0 H           H                                                     S F  F  CH.sub.3                                                                          0 H           H                                                     O F  F  CH.sub.3                                                                          0 H           H                                                     S H  Cl CH.sub.3                                                                          0 H           H                                                     O H  Cl CH.sub.3                                                                          0 H           H                                                     S F  Cl CH.sub.3                                                                          0 H           H                                                     O F  Cl CH.sub.3                                                                          0 H           H                                                     S H  F  H  0 4-CH.sub.3  H                                                     O H  F  H  0 4-CH.sub.3  H                                                     S F  F  H  0 4-CH.sub.3  H                                                     O F  F  H  0 4-CH.sub.3  H                                                     S H  Cl H  0 4-CH.sub. 3 H                                                     O H  Cl H  0 4-CH.sub.3  H                                                     S F  Cl H  0 4-CH.sub.3  H                                                     O F  Cl H  0 4-CH.sub.3  H                                                     S H  F  CH.sub.3                                                                          0 4-CH.sub.3  H                                                     O H  F  CH.sub.3                                                                          0 4-CH.sub.3  H                                                     S F  F  CH.sub.3                                                                          0 4-CH.sub.3  H                                                     O F  F  CH.sub.3                                                                          0 4-CH.sub.3  H                                                     S H  Cl CH.sub.3                                                                          0 4-CH.sub.3  H                                                     O H  Cl CH.sub.3                                                                          0 4-CH.sub.3  H                                                     S F  Cl CH.sub.3                                                                          0 4-CH.sub.3  H                                                     O F  Cl CH.sub.3                                                                          0 4-CH.sub.3  H                                                     S H  F  H  0 4,5-Di-CH.sub.3                                                                            H                                                     O H  F  H  0 4,5-Di-CH.sub.3                                                                            H                                                     S F  F  H  0 4,5-Di-CH.sub.3                                                                            H                                                     O F  F  H  0 4,5-Di-CH.sub.3                                                                            H                                                     S H  Cl H  0 4,5-Di-CH.sub.3                                                                            H                                                     O H  Cl H  0 4,5-Di-CH.sub.3                                                                            H                                                     S F  Cl H  0 4,5-Di-CH.sub.3                                                                            H                                                     O F  Cl H  0 4,5-Di-CH.sub.3                                                                            H                                                     S H  F  CH.sub.3                                                                          0 4,5-Di-CH.sub.3                                                                            H                                                     O H  F  CH.sub.3                                                                          0 4,5-Di-CH.sub.3                                                                            H                                                     S F  F  CH.sub.3                                                                          0 4,5-Di-CH.sub.3                                                                            H                                                     O F  F  CH.sub.3                                                                          0 4,5-Di-CH.sub.3                                                                            H                                                     S H  Cl CH.sub.3                                                                          0 4,5-Di-CH.sub.3                                                                            H                                                     O H  Cl CH.sub.3                                                                          0 4,5-Di-CH.sub.3                                                                            H                                                     S F  Cl CH.sub.3                                                                          0 4,5-Di-CH.sub.3                                                                            H                                                     O F  Cl CH.sub.3                                                                          0 4,5-Di-CH.sub.3                                                                            H                                                     S H  F  H  0 4-CH.sub.2 CH.sub.3                                                                        H                                                     O H  F  H  0 4-CH.sub.2 CH.sub.3                                                                        H                                                     S F  F  H  0 4-CH.sub.2 CH.sub.3                                                                        H                                                     O F  F  H  0 4-CH.sub.2 CH.sub.3                                                                        H                                                     S H  Cl H  0 4-CH.sub.2 CH.sub.3                                                                        H                                                     O H  Cl H  0 4-CH.sub.2 CH.sub.3                                                                        H                                                     S F  Cl H  0 4-CH.sub.2 CH.sub.3                                                                        H                                                     O F  Cl H  0 4-CH.sub.2 CH.sub.3                                                                        H                                                     S H  F  CH.sub.3                                                                          0 4-CH.sub.2 CH.sub.3                                                                        H                                                     O H  F  CH.sub.3                                                                          0 4-CH.sub.2 CH.sub.3                                                                        H                                                     S F  F  CH.sub.3                                                                          0 4-CH.sub.2 CH.sub.3                                                                        H                                                     O F  F  CH.sub.3                                                                          0 4-CH.sub.2 CH.sub.3                                                                        H                                                     S H  Cl CH.sub.3                                                                          0 4-CH.sub.2 CH.sub.3                                                                        H                                                     O H  Cl CH.sub.3                                                                          0 4-CH.sub.2 CH.sub.3                                                                        H                                                     S F  Cl CH.sub.3                                                                          0 4-CH.sub.2 CH.sub.3                                                                        H                                                     O F  Cl CH.sub.3                                                                          0 4-CH.sub.2 CH.sub. 3                                                                       H                                                     S H  F  H  1 H           H                                                     O H  F  H  1 H           H                                                     S F  F  H  1 H           H                                                     O F  F  H  1 H           H                                                     S H  Cl H  1 H           H                                                     O H  Cl H  1 H           H                                                     S F  Cl H  1 H           H                                                     O F  Cl H  1 H           H                                                     S H  F  CH.sub.3                                                                          1 H           H                                                     O H  F  CH.sub.3                                                                          1 H           H                                                     S F  F  CH.sub.3                                                                          1 H           H                                                     O F  F  CH.sub.3                                                                          1 H           H                                                     S H  Cl CH.sub.3                                                                          1 H           H                                                     O H  Cl CH.sub.3                                                                          1 H           H                                                     S F  Cl CH.sub.3                                                                          1 H           H                                                     O F  Cl CH.sub.3                                                                          1 H           H                                                     S H  F  H  1 4-CH.sub.3  H                                                     O H  F  H  1 4-CH.sub.3  H                                                     S F  F  H  1 4-CH.sub.3  H                                                     O F  F  H  1 4-CH.sub.3  H                                                     S H  Cl H  1 4-CH.sub.3  H                                                     O H  Cl H  1 4-CH.sub.3  H                                                     S F  Cl H  1 4-CH.sub.3  H                                                     O F  Cl H  1 4-CH.sub.3  H                                                     S H  F  CH.sub.3                                                                          1 4-CH.sub.3  H                                                     O H  F  CH.sub.3                                                                          1 4-CH.sub.3  H                                                     S F  F  CH.sub.3                                                                          1 4-CH.sub.3  H                                                     O F  F  CH.sub.3                                                                          1 4-CH.sub.3  H                                                     S H  Cl CH.sub.3                                                                          1 4-CH.sub.3  H                                                     O H  Cl CH.sub.3                                                                          1 4-CH.sub.3  H                                                     S F  Cl CH.sub.3                                                                          1 4-CH.sub.3  H                                                     O F  Cl CH.sub.3                                                                          1 4-CH.sub.3  H                                                     S H  F  H  1 4,6-Di-CH.sub.3                                                                            H                                                     O H  F  H  1 4,6-Di-CH.sub.3                                                                            H                                                     S F  F  H  1 4,6-Di-CH.sub.3                                                                            H                                                     O F  F  H  1 4,6-Di-CH.sub.3                                                                            H                                                     S H  Cl H  1 4,6-Di-CH.sub.3                                                                            H                                                     O H  Cl H  1 4,6-Di-CH.sub.3                                                                            H                                                     S F  Cl H  1 4,6-Di-CH.sub.3                                                                            H                                                     O F  Cl H  1 4,6-Di-CH.sub.3                                                                            H                                                     S H  F  CH.sub.3                                                                          1 4,6-Di-CH.sub.3                                                                            H                                                     O H  F  CH.sub.3                                                                          1 4,6-Di-CH.sub.3                                                                            H                                                     S F  F  CH.sub.3                                                                          1 4,6-Di-CH.sub.3                                                                            H                                                     O F  F  CH.sub.3                                                                          1 4,6-Di-CH.sub.3                                                                            H                                                     S H  Cl CH.sub.3                                                                          1 4,6-Di-CH.sub.3                                                                            H                                                     O H  Cl CH.sub.3                                                                          1 4,6-Di-CH.sub.3                                                                            H                                                     S F  Cl CH.sub.3                                                                          1 4,6-Di-CH.sub.3                                                                            H                                                     O F  Cl CH.sub.3                                                                          1 4,6-Di-CH.sub.3                                                                            H                                                     S H  F  H  1 4-CH.sub. 2 CH.sub.3                                                                       H                                                     O H  F  H  1 4-CH.sub.2 CH.sub.3                                                                        H                                                     S F  F  H  1 4-CH.sub.2 CH.sub.3                                                                        H                                                     O F  F  H  1 4-CH.sub.2 CH.sub.3                                                                        H                                                     S H  Cl H  1 4-CH.sub.2 CH.sub.3                                                                        H                                                     O H  Cl H  1 4-CH.sub.2 CH.sub.3                                                                        H                                                     S F  Cl H  1 4-CH.sub.2 CH.sub.3                                                                        H                                                     O F  Cl H  1 4-CH.sub.2 CH.sub.3                                                                        H                                                     S H  F  CH.sub.3                                                                          1 4-CH.sub.2 CH.sub.3                                                                        H                                                     O H  F  CH.sub.3                                                                          1 4-CH.sub.2 CH.sub.3                                                                        H                                                     S F  F  CH.sub.3                                                                          1 4-CH.sub.2 CH.sub.3                                                                        H                                                     O F  F  CH.sub.3                                                                          1 4-CH.sub.2 CH.sub.3                                                                        H                                                     S H  Cl CH.sub.3                                                                          1 4-CH.sub.2 CH.sub.3                                                                        H                                                     O H  Cl CH.sub.3                                                                          1 4-CH.sub.2 CH.sub.3                                                                        H                                                     S F  Cl CH.sub.3                                                                          1 4-CH.sub.2 CH.sub.3                                                                        H                                                     O F  Cl CH.sub.3                                                                          1 4-CH.sub.2 CH.sub.3                                                                        H                                                     __________________________________________________________________________

The thiadiazabicyclononane derivatives I. and herbicidal agents containing them, may be applied for instance in the form of directly separable solutions, powders, suspensions including high-percentage aqueous, oily or other suspensions), dispersions, emulsions, oil dispersions, pastes, dusts broadcasting agents, or granules by spraying, atomizing, dusting, broadcasting or watering. The forms of application depend entirely on the purpose for which the agents are being used, but they must ensure as fine a distribution of the active ingredients according to the invention as possible.

The compounds I are generally suitable for the preparation of directly separable solutions, emulsions, pastes and oil dispersions. Examples of suitable inert additives are mineral oil fractions of medium to high boiling point, such as kerosene or diesel oil further coal-tar oils, and oils of vegetable or animal origin, aliphatic, cyclic and aromatic hydrocarbons such as toluene, xylene, paraffin, tetrahydronaphthalene, alkylated naphthalenes and their derivatives, methanol, ethanol, propanol, butanol cyclohexanol, cyclohexanone, chlorobenzene, isophorone etc., and strongly polar solvents such as N,N-dimethylformamide, dimethyl sulfoxide, N-methylpyrrolidone, water, etc.

Aqueous formulations may be prepared from emulsion concentrates, pastes, oil dispersions, wettable powders or water-dispersible granules by adding water. To prepare emulsions, pastes and oil dispersions the ingredients as such or dissolved in an oil or solvent may be homogenized in water by means of wetting or dispersing agents, adherents or emulsifiers. Concentrates which are suitable for dilution with water may be prepared from active ingredient, wetting agent adherent, emulsifying or dispersing agent and possibly solvent or oil.

Examples of surfactants are: alkali metal, alkaline earth metal and ammonium salts of aromatic sulfonic acids, e.g., ligninsulfonic acid phenolsulfonic acid, naphthalenesulfonic acid and dibutylnaphthalenesulfonic acid and of fatty acids, alkyl and alkyl aryl sulfonates, and alkyl, lauryl ether and fatty alcohol sulfates, and salts of sulfated hexadecanols, heptadecanols and octadecanols salts of fatty alcohol glycol ethers, condensation products of sulfonated naphthalene and naphthalene derivatives with formaldehyde, condensation products of naphthalene or naphthalenesulfonic acids with phenol and formaldehyde, polyoxyethylene octylphenol ethers, ethoxylated isooctylphenol, ethoxylated octylphenol and ethoxylated nonylphenol alkylphenol polyglycol ethers, tributylphenyl polyglycol ethers, alkylaryl polyether alcohols, isotridecyl alcohol, fatty alcohol ethylene oxide condensates ethoxylated castor oil, polyoxyethylene alkyl ethers, ethoxylated polyoxypropylene, lauryl alcohol polyglycol ether acetal, sorbitol esters, lignin-sulfite waste liquors and methyl cellulose.

Powders, dusts and broadcasting agents may be prepared by mixing or grinding the active ingredients with a solid carrier.

Granules, e.g., coated, impregnated or homogeneous granules, may be prepared by bonding the active ingredients to solid carriers. Examples of solid carriers are mineral earths such as silicic acids silica gels, silicates, talc, kaolin, attapulgus clay, limestone, lime, chalk, bole, loess, clay, dolomite, diatomaceous earth calcium sulfate, magnesium sulfate magnesium oxide ground plastics fertilizers such as ammonium sulfate, ammonium phosphate, ammonium nitrate and ureas, and vegetable products such as grain meals, bark meal, wood meal, and nutshell meal, cellulosic powders etc.

The formulations contain from 0.1 to 95, and preferably 0.5 to 90, % by weight of active ingredient. The active ingredients are used in a purity of 90 to 100 and preferably 95 to 100, % (according to the NMR spectrum).

Examples of formulations are as follows:

I. A solution of 90 parts by weight of compound no. 3.01 and 10 parts by weight of N-methyl-alpha-pyrrolidone, which is suitable for application in the form of very fine drops.

II. A mixture of 20 parts by weight of compound no. 3.02. 80 parts by weight of xylene 10 parts by weight of the adduct of 8 to 10 moles of ethylene oxide and 1 mole of oleic acid-N-monoethanolamide, 5 parts by weight of the calcium salt of dodecylbenzenesulfonic acid, and 5 parts by weight of the adduct of 40 moles of ethylene oxide and 1 mole of castor oil. By finely distributing the solution in water, a dispersion is obtained.

III. An aqueous dispersion of 20 parts by weight of compound no. 3.03. 40 parts by weight of cyclohexanone, 30 parts by weight of isobutanol, 20 parts by weight of the adduct of 40 moles of ethylene oxide and 1 mole of castor oil.

IV. An aqueous dispersion of 20 parts by weight of compound no. 3.04, 25 parts by weight of cyclohexanone, 65 parts by weight of a mineral oil fraction having a boiling point between 210 and 280° C., and 10 parts by weight of the adduct of 40 moles of ethylene oxide and I mole of castor oil.

V. A mixture triturated in a hammer mill of 20 parts by weight of compound no. 3.05, 3 parts by weight of the sodium salt of diisobutylnaphthalene-alpha-sulfonic acid, 17 parts by weight of a lignin-sulfonic acid obtained from a sulfite waste liquor, and 60 parts by weight of powdered silica gel; by uniformly distributing the mixture in 20,000 parts by weight of water, a spray liquor is obtained containing 0.1 % by weight of the active ingredient.

VI. An intimate mixture of 3 parts by weight of compound no. 3.07 and 97 parts by weight of particulate kaolin. This dust contains 3% by weight of the active ingredient.

VII. An intimate mixture consisting of 30 parts by weight of compound no. 3.11, 92 parts by weight of powdered silica gel and 8 parts by weight of paraffin oil which has been sprayed onto the surface of this silica gel. This formulation gives the active ingredient good adherence.

VIII. A stable oily dispersion of 20 parts by weight of compound no. 3.12, 2 parts of the calcium salt of dodecylbenzenesulfonic acid 8 parts of a fatty alcohol polyglycol ether, 2 parts of the sodium salt of a phenolsulfonic acid-urea-formaldehyde condensate and 68 parts of a paraffinic mineral oil.

The active ingredients or the herbicidal agents containing them may be applied pre- or postemergence. If certain crop plants tolerate the active ingredients less well, application techniques may be used in which the herbicidal agents are sprayed from suitable equipment in such a manner that the leaves of sensitive crop plants are if possible not touched and the agents reach the soil or the unwanted plants growing beneath the crop plants post-directed, lay-by treatment).

The application rates depend on the objective to be achieved, the time of the Year, the plants to be combated and their growth stage, and are from 0.001 to 3.0, preferably 0.01 to 1.0, kg of active ingredient per hectare.

In view of the numerous application methods possible, the compounds according to the invention, or agents containing them, may be used in a large number of crops. Those which follow are given by way of example:

    ______________________________________                                         Botanical name         Common name                                             ______________________________________                                         Allium cepa            onions                                                  Ananas comosus         pineapples                                              Arachis hypogaea       peanuts                                                                        (groundnuts)                                            Asparagus officinalis  asparagus                                               Avena sativa           oats                                                    Beta vulgaris spp. altissima                                                                          sugarbeets                                              Beta vulgaris spp. rapa                                                                               fodder beets                                            Beta vulgaris spp. esculenta                                                                          table beets,                                                                   red beets                                               Brassica napus var. napus                                                                             rapeseed                                                Brassica napus var. napobrassica                                                                      swedes                                                  Brassica napus var. rapa                                                                              turnips                                                 Brassica rapa var. silvestris                                                  Camellia sinensis      tea plants                                              Carthamus tinctorius   safflower                                               Carya illinoinensis    pecan trees                                             Citrus limon           lemons                                                  Citrus maxima          grapefruits                                             Citrus reticulata      mandarins                                               Citrus sinensis        orange trees                                            Coffea arabica (Coffea canephora,                                                                     coffee plants                                           Coffea liberica)                                                               Cucumis melo           melons                                                  Cucumis sativus        cucumbers                                               Cynodon dactylon       Bermudagrass                                            Daucus carota          carrots                                                 Elais guineensis       oil palms                                               Fragaria vesca         strawberries                                            Glycine max            soybeans                                                Gossypium hirsutum (Gossypium arboreum,                                                               cotton                                                  Gossypium herbaceum,                                                           Gossypium vitifolium)                                                          Helianthus annuus      sunflowers                                              Helianthus tuberosus   Jerusalem artichoke                                     Hevea brasiliensis     rubber plants                                           Hordeum vulgare        barley                                                   Humulus lupulus       hops                                                    Ipomoea batatas        sweet potatoes                                          Juglans regia          walnut trees                                            Lactuca sativa         lettuce                                                 Lens culinaris         lentils                                                 Linum usitatissimum    flax                                                    Lycopersicon lycopersicum                                                                             tomatoes                                                Malus spp.             apple trees                                             Manihot esculenta      cassava                                                 Medicago sativa        alfalfa (lucerne)                                       Mentha piperita        peppermint                                              Musa spp.              banana plants                                           Nicotiana tabacum (N. rustica)                                                                        tobacco                                                 Olea europaea          olive trees                                             Oryza sativa           rice                                                    Panicum miliaceum      millet                                                  Phaseolus lunatus      limabeans                                               Phaseolus mungo        mungbeans                                               Phaseolus vulgaris     snapbeans,                                                                     green beans,                                                                   dry beans                                               Pennisetum glaucum     pearl millet                                            Petroselinum crispum spp. tuberosum                                                                   parsley                                                 Picea abies            Norway spruce                                           Abies alba             fir trees                                               Pinus spp.             pine trees                                              Pisum sativum          English peas                                            Prunus avium           cherry trees                                            Prunus domestica       plum trees                                              Prunus dulcis          almond trees                                            Prunus persica         peach trees                                             Pyrus communis         pear trees                                              Ribes silvestre        redcurrants                                             Ribes uva-crispa       gooseberries                                            Ricinus communis       castor-oil plants                                       Saccharum officinarum  sugar cane                                              Secale cereale         rye                                                     Sesamum indicum        sesame                                                  Solanum tuberosum      Irish potatoes                                          Sorghum bicolor (s. vulgare)                                                                          sorghum                                                 Sorghum dochna         sorgo                                                   Spinacia oleracea      spinach                                                 Theobroma cacao        cacao plants                                            Trifolium pratense     red clover                                              Triticum aestivum      wheat                                                   Triticum durum         durum wheat                                             Vaccinium corymbosum   blueberries                                             Vaccinium vitis-idaea  cranberries                                             Vicia faba             tick beans                                              Vigna sinensis (V. unguiculata)                                                                       cow peas                                                Vitis vinifera         grapes                                                  Zea mays               Indian corn,                                                                   sweet corn                                              ______________________________________                                    

To increase the spectrum of action and to achieve synergistic effects, the acetals and thioacetals I may be mixed with each other, or mixed and applied together with numerous representatives of other herbicidal or growth-regulating active ingredient groups. Examples of suitable components are diazines, 4H-3,1-benzoxazine derivatives, benzothiadiazinones, 2,6-dinitroanilines, N-phenylcarbamates, thiolcarbamates, halocarboxylic acids, triazines, amides, ureas, diphenyl ethers, triazinones uracils, benzofuran derivaties, cyclohexane-1,3-dione derivaties, quinolinecarboxylic acids (hetero)-aryloxyphenoxypropionic acid derivatives (salts, esters amides), etc.

It may also be useful to apply the herbicidal compounds I, either alone or in combination with other herbicides, in admixture with other crop protection agents, e.g., agents for combating pests or phytopathogenic fungi or bacteria. The compounds may also be mixed with solutions of mineral salts used to remedy nutritional or trace element deficiencies. Non-phytotoxic oils and oil concentrates may also be added.

SYNTHESIS EXAMPLES EXAMPLE 1

9-[(4-Methyl-1,3-dithiolan-2-yl)-4-chlorophenylimino]-8-thia-1,6-diazabicyclo[4.3.0]nonan-7-one compound No. 3.12 in Table 3) ##STR5##

2.2 g (0.011 mol) of trichloromethyl chloroformate in 20 ml of methylene chloride were added dropwise at from 25 to 30° C. to a mixture of 3.7 g (0.01 mol) of N-[4-chloro-3-(3-methyl-1,3-dithiolan-2-yl)phenylthiocarbamoyl]hexahydropyridazine, 1.7 g (0.022 mol) of pyridine and 130 ml of methylene chloride. The mixture was then stirred at 25° C. for 2 hours, washed 3 times with 50 ml of water in each case until neutral and evaporated. The crude product was recrystallized from petroleum ether. Yield: 88%.

Precursor 1α)

4-Chloro-3-(4-methyl-1,3-dithiolan-2-yl)nitrobenzene ##STR6##

22.8 g (0.21 mol) of 1,2-propanedithiol were added to a solution of 37.1 g (0.2 mol) of 2-chloro-5-nitrobenzaldehyde, 1 g (5.10⁻³ mol) of p-toluenesulfonic acid and 500 ml of toluene, and the mixture was refluxed for 5 hours on a water separator. After cooling, the solvent was removed and the residue was washed with petroleum ether. Yield: 94%; m.p.: 55° C.

Precursor 1β)

4-Chloro-3-(4-methyl-1,3-dithiolan-2-yl)aniline ##STR7##

51.5 g (0.19 mol) of 4-chloro-3-(4-methyl-1,3-dithiolan-2-yl)nitrobenzene were added to a mixture of 31.5 g (0.56 mol) of iron powder in 100 ml of methanol and 150 ml of glacial acetic acid in a flask fitted with reflux condenser, and the mixture was heated for 2 hours. 400 ml of water were stirred into the mixture, the latter was filtered with suction, the filtrate was extracted with ethyl acetate, and the organic phase was washed with water, dried and evaporated. Yield: 81%; oil.

Precursor 1γ)

2-(4-Methyl-1,3-dithiolan-2-yl)-4-isothiocyanatochlorobenzene ##STR8##

12.3 g (0.05 mol) of 4-chloro-3-(4-methyl)-1,3-dithiolan-2-yl)aniline in 100 ml of methylene chloride were added dropwise at from 25 to 30° C. to a mixture of 6.3 g (0.055 mol) of thiophosgene, 50 ml of methylene chloride and 100 ml of water. The mixture was stirred at 25° C. for 2 hours, and the organic phase was separated off, washed twice with 50 ml of saturated sodium bicarbonate solution and water in each case until neutral, dried and evaporated. Yield: 90%; oil.

Precursor 1δ)

N-[4-chloro-3-(3-methyl-1,3-dithiolan-2-yl)phenylthiocarbamoyl]hexahydropyridazine ##STR9##

13 g (0.045 mol) of 2-(4-methyl-1,3-dithiolan-2-yl)-4-isothiocyanatochlorobenzene in 50 ml of tetrahydrofuran were added dropwise at from 25 to 30° C. to a solution of 4.3 g (0.05 mol) of piperazine in 200 ml of tetrahydrofuran. After 2 hours at 25° C., the solvent was removed. Yield: 59%; m.p.: 124-125° C.

EXAMPLE 2

7-[(1,3-Dithiolan-2-yl)-4-chlorophenylimino]-8-thia-1,6diazabicyclo[4.3.0]non-2-en -9-one (compound No. 3.04 in Table 3) ##STR10##

Two portions each of 1.2 g (11 mmol) of 1,3-propanedithiol were added to a mixture of 3.1 g (10 mmol) of 7-(2-formyl-4-chlorophenylimino)-8-thia-1,6-diazabicyclo[4.3.0]non-2-en-9-one, 0.1 g (0.5 mmol) of p-toluenesulfonic acid and 200 ml of toluene, and the mixture was refluxed for 15 hours while removing the water of reaction. The mixture was then washed twice with 50 ml of 10% strength by weight sodium hydroxide solution in each case and 3 times with water, and the product was subsequently worked up Yield: 63%.

Precursor 2α)

2-(1,3-Dioxolan-2-yl)-4-isothiocyanatochlorobenzene ##STR11##

6.3 g (0.55 mol) of thiophosgene were added dropwise with ice cooling to a solution of 100 g (0.5 mol) of 4-chloro-3-(1,3-dioxolan-2-yl)aniline and 60 g (0.6 mol) of triethylamine in 1 1 of dichloromethane. The mixture was stirred at 25° C. for 2 hours, washed 3 times with 500 ml of water in each case and then dried using sodium sulfate. The solvent was subsequently removed. Yield: quantitative; m.p.: 93-94° C.

Precursor 2β)

N-(4-chloro-3-(1,3-dioxolan-2-yl)phenylthiocarbamoyl]1,4,5,6-tetrahydropyridazine ##STR12##

A solution of the crude precursor 2α) (about 0.5 mol of 2-(1,3-dioxolan-2-yl)-4-isothiocyanatochlorobenzene) in 500 ml of tetrahydrofuran was added dropwise at 25° C. to a solution of 42 g (0.5 mol) of 1,4,5,6-tetrahydropyridazine in 750 ml of tetrahydrofuran. The mixture was stirred at 25° C. for 2 hours, the solvent was removed, and the residue was stirred with 500 ml of ethanol. The solid material suspended in the solution was filtered off and dried. Yield: 58%; m.p.: 112-114° C.

Precursor 2γ)

2-Formyl-4-chlorophenylimino)-8-thia-1 6-diazabicyclo[4.3.0]non-2-en-9-one ##STR13##

50 g (0.25 mol) of trichloromethyl chloroformate in 200 ml of methylene chloride were added dropwise at from 25 to 30° C. to a mixture of 81.5 g (0.25 mol) of N[4-chloro-3-(1,3-dioxolan-2-yl) phenylthiocarbamoyl]-1,4,5,6-tetraydropyridazine, 43 g (0.55 mol) of pyridine and 500 ml of methylene chloride. The mixture was then stirred at 25° C. for 5 hours, and 500 ml of water were added dropwise with ice cooling. The phases were separated, and the organic phase was washed until neutral and evaporated. The residue was hydrolyzed for 20 hours at from 40 to 45° C. using 540 ml of concentrated acetic acid. 300 ml of water were then added to the solution at 25° C. The solid which formed was filtered off, washed with water until neutral and dried. Yield : 61%; m.p.: 145-146° C.

The physical data of the products I are shown in Table 3 below, in which further compounds I which were prepared or can be prepared in the same way are also shown.

                                      TABLE 3                                      __________________________________________________________________________      ##STR14##                                                                        Double bond in the thia-          Phys. data                                No.                                                                               diazabicyclononane moiety                                                                   Y Z R.sup.4                                                                           R.sup.5     m mp [°C.]; IR [cm.sup.-1 ];                                              NMR [ppm]                                 __________________________________________________________________________     3.01                                                                              yes          S S H  H           1 180-183                                   3.02                                                                              yes          O O H  H           0 1695, 1627, 1290, 1262                    3.03                                                                              yes          O O H  H           1 129-130                                   3.04                                                                              yes          S S H  H           0 139-140                                   3.05                                                                              yes          S S CH.sub.3                                                                          H           0 1694, 1626, 1584, 1288, 1266              3.06                                                                              yes          O S H  H           0 1691, 1618, 1586, 1262                    3.07                                                                              yes          O O CH.sub.3                                                                          6-CH.sub.3  1 1694, 1630, 1592, 1263                    3.08                                                                              yes          O O CH.sub.3                                                                          5-CH.sub.3  0 1696, 1628, 1262, 1089                    3.09                                                                              yes          O O CH.sub.3                                                                          5-COO(CH.sub.2).sub.3 CH.sub.3                                                             0 1731, 1697, 1628, 1266                    3.10                                                                              yes          O O CH.sub.3                                                                          5-COO(CH.sub.2).sub.3 CH.sub.3                                                             0                                           3.11                                                                              yes          O O H  5-CH.sub.2 OCH.sub.2 CHCH.sub.2                                                            0 1696, 1627, 1263, 1093                    3.12                                                                              no           S S CH.sub.3                                                                          H           0 121-122                                   __________________________________________________________________________

Use examples

The herbicidal action of the thiadiazabicyclononane derivatives of the formula I is illustrated in the following greenhouse experiments.

The vessels employed were plastic flowerpots having a volume of 300 cm³ and filled with a sandy loam containing about 3.0% humus. The seeds of the test plants were sown separately, according to species.

In the preemergence treatment, the active ingredients suspended or emulsified in water, were applied through finely distributing nozzles immediately after sowing. The vessels were lightly irrigated to induce germination and growth, and covered with transparent plastic hoods until the plants had taken root. This cover ensured uniform germination of the test plants, insofar as this was not impaired by the active ingredients.

For the postemergence treatment, the plants were grown depending on growth form to a height of 3 to 15 cm before being treated with the active ingredients, which were suspended or emulsified in water. The application rate for postemergence treatment was 0.03 kg/ha.

The pots were set up in the greenhouse, species from warmer climates in warmer areas (20 to 35° C.) and species from moderate climates at 10 to 25° C. The experiments were run for from 2 to 4 weeks. During this time the plants were tended and their reactions to the various treatments assessed.

The assessment scale was 0 to 100, 100 denoting nonemergence or complete destruction of at least the visible plant parts, and 0 denoting no damage or normal growth.

The plants used in the experiments were Triticum aestivum cassia tora, Chenopodium album and Ipomoea spp.

The results show that compound no. 3.12, applied postemergence, completely destroyed the broadleaved plants, wheat, the crop plant, remained undamaged. 

We claim:
 1. Thiadiazabicyclononane derivatives of the general formula I ##STR15## where the dotted bond is a possible additional bond and the substituents have the following meanings:R¹ hydrogen or fluorine; R² halogen; R³ hydrogen or C₁ -C₄ -alkyl; R⁴ hydrogen, C₁ -C₈ -alkoxycarbonyl, C₃ -C₆ -alkenyloxycarbonyl or C₃ -C₆ -alkynyloxycarbonyl, it being possible for each of these three groups to additionally bear a C₁ -C₄ -alkoxy radical; X,Y,Z oxygen or sulfur; A a C₂ -C₃ -alkylene chain which, in addition to R⁴, may bear up to three, identical or different radicals R⁵ hydroxyl, carboxyl C₁ -C-₄ -alkyl or C₁ -C₆ -alkoxycarbonyl, and these last two radicals in turn may bear up to 5 halogen atoms and/or one of the following substituents: hydroxyl, cyano, mercapto, C₁ -C₄ -alkoxy, C₁ -C₆ -alkylthio, C₃ -C₆ -alkenyloxy, C₃ -C₆ -alkenylthio C₃ -C₆ -alkynyloxy, C₃ -C₆ -alkynylthio, C₁ -C₆ -alkylcarbonyloxy, C₁ -C₆ -alkoxycarbonyl, C₁ -C₆ -alkoxycarbonyl-C₁ -C-₄ -alkoxy or C₁ -C₆ -alkoxycarbonyl-C₁ -C₆ -alkylthio.
 2. Thiadiazabicyclononane derivatives I as set forth in claim 1 where R¹ and R³ are hydrogen, R² is chlorine and x is oxygen.
 3. Herbicidal agents containing a herbicidally effective amount of an acetal of the formula I as set forth in claim 1 and conventional additives.
 4. Herbicidal agents as set forth in claim 3, containing a herbicidally effective amount of an acetal of the formula I and further active constituents.
 5. A process for combating the growth of unwanted plants, wherein a herbicidally effective amount of an acetal of the formula I as set for in claim 1 is allowed to act on plants, their habitat or on seed. 